It is suspected that excess of brain cholesterol plays a role in Alzheimer's disease (AD). Membrane-associated cholesterol was shown to be increased in the brain of individuals with sporadic AD and to correlate with the severity of the disease. We hypothesized that an increase of membrane cholesterol could trigger sporadic AD early phenotypes.
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Bibliographic reference
Marquer, Catherine ; Laine, Jeanne ; Dauphinot, Luce ; Hanbouch, Linda ; Lemercier-Neuillet, Camille ; et. al. Increasing membrane cholesterol of neurons in culture recapitulates Alzheimer's disease early phenotypes.. In: Molecular Neurodegeneration, Vol. 9, no.1, p. 60 (2014)
