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The Val158Met polymorphism of the COMT gene is associated with increased pain sensitivity in morphine-treated patients undergoing a painful procedure after cardiac surgery.

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Ahlers, Sabine J G M Elens, Laure [UCL] van Gulik, Laura van Schaik, Ron H van Dongen, Eric P A Knibbe, Catherijne A J

The catechol-O-methyltransferase (COMT) Val158Met polymorphism affected pain sensitivity of healthy volunteers upon application of experimental pain stimuli. The relevance of these findings in morphine-treated postoperative cardiac patients undergoing painful healthcare procedures is unknown; therefore, the aim of this study was to investigate whether the COMT Val158Met polymorphism increases pain sensitivity in morphine-treated patients undergoing an unavoidable painful routine procedure after cardiac surgery.

Document type Article de périodique (Journal article)
Access type Accès restreint
Publication date 2013
Language Anglais
Journal information "British Journal of Clinical Pharmacology" - Vol. 75, no.6, p. 1506-1515 (2013)
Peer reviewed yes
Publisher Wiley-Blackwell Publishing Ltd. (Chichester)
issn 0306-5251
e-issn 1365-2125
Affiliation UCL - SSS/LDRI - Louvain Drug Research Institute
MESH Subject Aged ; Morphine ; Netherlands ; Pain ; Pain Measurement ; Pain Threshold ; Polymorphism, Single Nucleotide ; Postoperative Period ; Prospective Studies ; Aged, 80 and over ; Analgesics, Opioid ; Cardiac Surgical Procedures ; Catechol O-Methyltransferase ; Female ; Humans ; Male ; Middle Aged
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Bibliographic reference Ahlers, Sabine J G M ; Elens, Laure ; van Gulik, Laura ; van Schaik, Ron H ; van Dongen, Eric P A ; et. al. The Val158Met polymorphism of the COMT gene is associated with increased pain sensitivity in morphine-treated patients undergoing a painful procedure after cardiac surgery.. In: British Journal of Clinical Pharmacology, Vol. 75, no.6, p. 1506-1515 (2013)
Permanent URL http://hdl.handle.net/2078.1/161650