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Modern Detection of Prostate Cancer's Bone Metastasis: Is the Bone Scan Era Over?

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Tombal, Bertrand [UCL] Lecouvet, Frédéric [UCL]

Prostate cancer cells have an exquisite tropism for bone, which clinically translates into the highest rate of bone metastases amongst male cancers. Although in the latest years there has been an active development of new "bone targeted" therapies, modern diagnostic techniques for bone metastases still relies mostly on (99m)Tc bone scanning (BS) and plain X-ray. BS dramatically lacks specificity and sensitivity. Recent publications using modern imaging technologies have clearly pinpointed that BS grossly underestimates the true prevalence of bone metastasis. In addition BS does not allow tumour measurement and is, therefore, not appropriate to monitor response to therapy. This might be extremely important in patients harbouring high-risk localized disease that are eventually candidate for local therapy. Here we reviewed what are the emerging imaging strategies that are likely to supplant BS and to what extent they can be used in the clinic already.

Document type Article de périodique (Journal article) – Synthèse de littérature
Access type Accès libre
Publication date 2012
Language Anglais
Journal information "Advances in Urology" - Vol. 2012, p. 893193 [1-8] (2012)
Peer reviewed yes
Publisher Hindawi Publishing Corporation ((Egypt) Cairo)
issn 1687-6369
e-issn 1687-6377
Publication status Publié
Affiliations UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation
UCL - SSS/IREC/IMAG - Pôle d'imagerie médicale
UCL - (SLuc) Service d'urologie
UCL - (SLuc) Service de radiologie
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Bibliographic reference Tombal, Bertrand ; Lecouvet, Frédéric. Modern Detection of Prostate Cancer's Bone Metastasis: Is the Bone Scan Era Over?. In: Advances in Urology, Vol. 2012, p. 893193 [1-8] (2012)
Permanent URL http://hdl.handle.net/2078.1/158471