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Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status

  1. Larsen Nadja, Vogensen Finn K., van den Berg Frans W. J., Nielsen Dennis Sandris, Andreasen Anne Sofie, Pedersen Bente K., Al-Soud Waleed Abu, Sørensen Søren J., Hansen Lars H., Jakobsen Mogens, Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults, 10.1371/journal.pone.0009085
  2. Wu Xiaokang, Ma Chaofeng, Han Lei, Nawaz Muhammad, Gao Fei, Zhang Xuyan, Yu Pengbo, Zhao Chang’an, Li Lianchuan, Zhou Aiping, Wang Juan, Moore John E., Cherie Millar B., Xu Jiru, Molecular Characterisation of the Faecal Microbiota in Patients with Type II Diabetes, 10.1007/s00284-010-9582-9
  3. Qin Junjie, Li Yingrui, Cai Zhiming, Li Shenghui, Zhu Jianfeng, Zhang Fan, Liang Suisha, Zhang Wenwei, Guan Yuanlin, Shen Dongqian, Peng Yangqing, Zhang Dongya, Jie Zhuye, Wu Wenxian, Qin Youwen, Xue Wenbin, Li Junhua, Han Lingchuan, Lu Donghui, Wu Peixian, Dai Yali, Sun Xiaojuan, Li Zesong, Tang Aifa, Zhong Shilong, Li Xiaoping, Chen Weineng, Xu Ran, Wang Mingbang, Feng Qiang, Gong Meihua, Yu Jing, Zhang Yanyan, Zhang Ming, Hansen Torben, Sanchez Gaston, Raes Jeroen, Falony Gwen, Okuda Shujiro, Almeida Mathieu, LeChatelier Emmanuelle, Renault Pierre, Pons Nicolas, Batto Jean-Michel, Zhang Zhaoxi, Chen Hua, Yang Ruifu, Zheng Weimou, Li Songgang, Yang Huanming, Wang Jian, Ehrlich S. Dusko, Nielsen Rasmus, Pedersen Oluf, Kristiansen Karsten, Wang Jun, A metagenome-wide association study of gut microbiota in type 2 diabetes, 10.1038/nature11450
  4. Karlsson Fredrik H., Tremaroli Valentina, Nookaew Intawat, Bergström Göran, Behre Carl Johan, Fagerberg Björn, Nielsen Jens, Bäckhed Fredrik, Gut metagenome in European women with normal, impaired and diabetic glucose control, 10.1038/nature12198
  5. Turnbaugh Peter J., Ley Ruth E., Mahowald Michael A., Magrini Vincent, Mardis Elaine R., Gordon Jeffrey I., An obesity-associated gut microbiome with increased capacity for energy harvest, 10.1038/nature05414
  6. Cani P. D., Amar J., Iglesias M. A., Poggi M., Knauf C., Bastelica D., Neyrinck A. M., Fava F., Tuohy K. M., Chabo C., Waget A., Delmee E., Cousin B., Sulpice T., Chamontin B., Ferrieres J., Tanti J.-F., Gibson G. R., Casteilla L., Delzenne N. M., Alessi M. C., Burcelin R., Metabolic Endotoxemia Initiates Obesity and Insulin Resistance, 10.2337/db06-1491
  7. Cani P. D., Bibiloni R., Knauf C., Waget A., Neyrinck A. M., Delzenne N. M., Burcelin R., Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice, 10.2337/db07-1403
  8. Adolph T. E., Nature, 503, 272 (2013)
  9. Rosenstiel Philip, Stories of love and hate : innate immunity and host–microbe crosstalk in the intestine, 10.1097/mog.0b013e32835da2c7
  10. Vijay-Kumar M., Aitken J. D., Carvalho F. A., Cullender T. C., Mwangi S., Srinivasan S., Sitaraman S. V., Knight R., Ley R. E., Gewirtz A. T., Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5, 10.1126/science.1179721
  11. Kim Kyung-Ah, Gu Wan, Lee In-Ah, Joh Eun-Ha, Kim Dong-Hyun, High Fat Diet-Induced Gut Microbiota Exacerbates Inflammation and Obesity in Mice via the TLR4 Signaling Pathway, 10.1371/journal.pone.0047713
  12. Wen Li, Ley Ruth E., Volchkov Pavel Yu., Stranges Peter B., Avanesyan Lia, Stonebraker Austin C., Hu Changyun, Wong F. Susan, Szot Gregory L., Bluestone Jeffrey A., Gordon Jeffrey I., Chervonsky Alexander V., Innate immunity and intestinal microbiota in the development of Type 1 diabetes, 10.1038/nature07336
  13. Hosoi Toru, Yokoyama Shota, Matsuo Suguru, Akira Shizuo, Ozawa Koichiro, Myeloid Differentiation Factor 88 (MyD88)-Deficiency Increases Risk of Diabetes in Mice, 10.1371/journal.pone.0012537
  14. Kleinridders André, Schenten Dominik, Könner A. Christine, Belgardt Bengt F., Mauer Jan, Okamura Tomoo, Wunderlich F. Thomas, Medzhitov Ruslan, Brüning Jens C., MyD88 Signaling in the CNS Is Required for Development of Fatty Acid-Induced Leptin Resistance and Diet-Induced Obesity, 10.1016/j.cmet.2009.08.013
  15. Yokoyama Shota, Hosoi Toru, Ozawa Koichiro, Stearoyl-CoA Desaturase 1 (SCD1) is a key factor mediating diabetes in MyD88-deficient mice, 10.1016/j.gene.2012.01.024
  16. Osborn Olivia, Olefsky Jerrold M, The cellular and signaling networks linking the immune system and metabolism in disease, 10.1038/nm.2627
  17. Schwartz D. R., Trends Endocrinol. Metab., 22, 259 (2011)
  18. Backhed F., Ding H., Wang T., Hooper L. V., Koh G. Y., Nagy A., Semenkovich C. F., Gordon J. I., The gut microbiota as an environmental factor that regulates fat storage, 10.1073/pnas.0407076101
  19. Mandard Stéphane, Zandbergen Fokko, van Straten Esther, Wahli Walter, Kuipers Folkert, Müller Michael, Kersten Sander, The Fasting-induced Adipose Factor/Angiopoietin-like Protein 4 Is Physically Associated with Lipoproteins and Governs Plasma Lipid Levels and Adiposity, 10.1074/jbc.m506519200
  20. Neyrinck Audrey M., Bindels Laure B., De Backer Fabienne, Pachikian Barbara D., Cani Patrice D., Delzenne Nathalie M., Dietary supplementation with chitosan derived from mushrooms changes adipocytokine profile in diet-induced obese mice, a phenomenon linked to its lipid-lowering action, 10.1016/j.intimp.2009.02.015
  21. Soronen Jarkko, Laurila Pirkka-Pekka, Naukkarinen Jussi, Surakka Ida, Ripatti Samuli, Jauhiainen Matti, Olkkonen Vesa M, Yki-Järvinen Hannele, Adipose tissue gene expression analysis reveals changes in inflammatory, mitochondrial respiratory and lipid metabolic pathways in obese insulin-resistant subjects, 10.1186/1755-8794-5-9
  22. Everard A., Belzer C., Geurts L., Ouwerkerk J. P., Druart C., Bindels L. B., Guiot Y., Derrien M., Muccioli G. G., Delzenne N. M., de Vos W. M., Cani P. D., Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity, 10.1073/pnas.1219451110
  23. Muccioli Giulio G, Naslain Damien, Bäckhed Fredrik, Reigstad Christopher S, Lambert Didier M, Delzenne Nathalie M, Cani Patrice D, The endocannabinoid system links gut microbiota to adipogenesis, 10.1038/msb.2010.46
  24. Geurts Lucie, Lazarevic Vladimir, Derrien Muriel, Everard Amandine, Van Roye Marie, Knauf Claude, Valet Philippe, Girard Myriam, Muccioli Giulio G., François Patrice, de Vos Willem M., Schrenzel Jacques, Delzenne Nathalie M., Cani Patrice D., Altered Gut Microbiota and Endocannabinoid System Tone in Obese and Diabetic Leptin-Resistant Mice: Impact on Apelin Regulation in Adipose Tissue, 10.3389/fmicb.2011.00149
  25. Kanarek Naama, Grivennikov Sergei I., Leshets Michael, Lasry Audrey, Alkalay Irit, Horwitz Elad, Shaul Yoav D., Stachler Matthew, Voronov Elena, Apte Ron N., Pagano Michele, Pikarsky Eli, Karin Michael, Ghosh Sankar, Ben-Neriah Yinon, Critical role for IL-1β in DNA damage-induced mucositis, 10.1073/pnas.1322691111
  26. Al-Sadi Rana, Guo Shuhong, Dokladny Karol, Smith Matthew A., Ye Dongmei, Kaza Archana, Watterson D. Martin, Ma Thomas Y., Mechanism of Interleukin-1β Induced-Increase in Mouse Intestinal PermeabilityIn Vivo, 10.1089/jir.2012.0031
  27. Al-Sadi Rana, Ye Dongmei, Said Hamid M., Ma Thomas Y., IL-1β-Induced Increase in Intestinal Epithelial Tight Junction Permeability Is Mediated by MEKK-1 Activation of Canonical NF-κB Pathway, 10.2353/ajpath.2010.100371
  28. Dupaul-Chicoine Jeremy, Yeretssian Garabet, Doiron Karine, Bergstrom Kirk S.B., McIntire Christian R., LeBlanc Philippe M., Meunier Charles, Turbide Claire, Gros Philippe, Beauchemin Nicole, Vallance Bruce A., Saleh Maya, Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases, 10.1016/j.immuni.2010.02.012
  29. Zaki Md. Hasan, Boyd Kelli L., Vogel Peter, Kastan Michael B., Lamkanfi Mohamed, Kanneganti Thirumala-Devi, The NLRP3 Inflammasome Protects against Loss of Epithelial Integrity and Mortality during Experimental Colitis, 10.1016/j.immuni.2010.03.003
  30. Vaishnava S., Yamamoto M., Severson K. M., Ruhn K. A., Yu X., Koren O., Ley R., Wakeland E. K., Hooper L. V., The Antibacterial Lectin RegIII  Promotes the Spatial Segregation of Microbiota and Host in the Intestine, 10.1126/science.1209791
  31. Frantz A L, Rogier E W, Weber C R, Shen L, Cohen D A, Fenton L A, Bruno M E C, Kaetzel C S, Targeted deletion of MyD88 in intestinal epithelial cells results in compromised antibacterial immunity associated with downregulation of polymeric immunoglobulin receptor, mucin-2, and antibacterial peptides, 10.1038/mi.2012.23
  32. Everard Amandine, Lazarevic Vladimir, Gaïa Nadia, Johansson Maria, Ståhlman Marcus, Backhed Fredrik, Delzenne Nathalie M, Schrenzel Jacques, François Patrice, Cani Patrice D, Microbiome of prebiotic-treated mice reveals novel targets involved in host response during obesity, 10.1038/ismej.2014.45
  33. Nutsch Katherine M, Hsieh Chyi-Song, T cell tolerance and immunity to commensal bacteria, 10.1016/j.coi.2012.04.009
  34. Round J. L., Mazmanian S. K., Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota, 10.1073/pnas.0909122107
  35. Fontenot Jason D, Rudensky Alexander Y, A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3, 10.1038/ni1179
  36. Feuerer Markus, Herrero Laura, Cipolletta Daniela, Naaz Afia, Wong Jamie, Nayer Ali, Lee Jongsoon, Goldfine Allison B, Benoist Christophe, Shoelson Steven, Mathis Diane, Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters, 10.1038/nm.2002
  37. Sheridan Brian S., Romagnoli Pablo A., Pham Quynh-Mai, Fu Han-Hsuan, Alonzo Francis, Schubert Wolf-Dieter, Freitag Nancy E., Lefrançois Leo, γδ T Cells Exhibit Multifunctional and Protective Memory in Intestinal Tissues, 10.1016/j.immuni.2013.06.015
  38. Spits Hergen, Artis David, Colonna Marco, Diefenbach Andreas, Di Santo James P., Eberl Gerard, Koyasu Shigeo, Locksley Richard M., McKenzie Andrew N. J., Mebius Reina E., Powrie Fiona, Vivier Eric, Innate lymphoid cells — a proposal for uniform nomenclature, 10.1038/nri3365
  39. Turnbaugh Peter J., Bäckhed Fredrik, Fulton Lucinda, Gordon Jeffrey I., Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome, 10.1016/j.chom.2008.02.015
  40. Zhang Xu, Zhao Yufeng, Zhang Menghui, Pang Xiaoyan, Xu Jia, Kang Chaoying, Li Meng, Zhang Chenhong, Zhang Zhiguo, Zhang Yifei, Li Xiaoying, Ning Guang, Zhao Liping, Structural Changes of Gut Microbiota during Berberine-Mediated Prevention of Obesity and Insulin Resistance in High-Fat Diet-Fed Rats, 10.1371/journal.pone.0042529
  41. Bäckhed Fredrik, Manchester Jill K., Semenkovich Clay F., Gordon Jeffrey I., Mechanisms underlying the resistance to diet-induced obesity in germ-free mice, 10.1073/pnas.0605374104
  42. Fleissner Christine K., Huebel Nora, Abd El-Bary Mohamed Mostafa, Loh Gunnar, Klaus Susanne, Blaut Michael, Absence of intestinal microbiota does not protect mice from diet-induced obesity, 10.1017/s0007114510001303
  43. Mizutani N., Ozaki N., Seino Y., Fukami A., Sakamoto E., Fukuyama T., Sugimura Y., Nagasaki H., Arima H., Oiso Y., Reduction of Insulin Signaling Upregulates Angiopoietin-like Protein 4 Through Elevated Free Fatty Acids in Diabetic Mice, 10.1055/s-0031-1291258
  44. Brown Russell, Imran Syed A., Wilkinson Michael, Lipopolysaccharide (LPS) stimulates adipokine and socs3 gene expression in mouse brain and pituitary gland in vivo, and in N-1 hypothalamic neurons in vitro, 10.1016/j.jneuroim.2009.02.001
  45. Lu Biao, Moser Arthur, Shigenaga Judy K., Grunfeld Carl, Feingold Kenneth R., The acute phase response stimulates the expression of angiopoietin like protein 4, 10.1016/j.bbrc.2009.12.145
  46. Alhouayek M., Lambert D. M., Delzenne N. M., Cani P. D., Muccioli G. G., Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation, 10.1096/fj.10-176602
  47. Hansen Katrine B., Rosenkilde Mette M., Knop Filip K., Wellner Niels, Diep Thi A., Rehfeld Jens F., Andersen Ulrik B., Holst Jens J., Hansen Harald S., 2-Oleoyl Glycerol Is a GPR119 Agonist and Signals GLP-1 Release in Humans, 10.1210/jc.2011-0647
  48. Cani P. D., Possemiers S., Van de Wiele T., Guiot Y., Everard A., Rottier O., Geurts L., Naslain D., Neyrinck A., Lambert D. M., Muccioli G. G., Delzenne N. M., Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability, 10.1136/gut.2008.165886
  49. Bevins Charles L., Salzman Nita H., Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis, 10.1038/nrmicro2546
  50. Pott Johanna, Hornef Mathias, Innate immune signalling at the intestinal epithelium in homeostasis and disease, 10.1038/embor.2012.96
  51. Hooper Lora V., Macpherson Andrew J., Immune adaptations that maintain homeostasis with the intestinal microbiota, 10.1038/nri2710
  52. El Marjou Fatima, Janssen Klaus-Peter, Hung-Junn Chang Benny, Li Mei, Hindie Val�rie, Chan Lawrence, Louvard Daniel, Chambon Pierre, Metzger Daniel, Robine Sylvie, Tissue-specific and inducible Cre-mediated recombination in the gut epithelium, 10.1002/gene.20042
  53. Joly-Amado Aurélie, Denis Raphaël G P, Castel Julien, Lacombe Amélie, Cansell Céline, Rouch Claude, Kassis Nadim, Dairou Julien, Cani Patrice D, Ventura-Clapier Renée, Prola Alexandre, Flamment Melissa, Foufelle Fabienne, Magnan Christophe, Luquet Serge, Hypothalamic AgRP-neurons control peripheral substrate utilization and nutrient partitioning : AgRP-neurons controls peripheral energy fluxes, 10.1038/emboj.2012.250
  54. Dewulf Evelyne M, Cani Patrice D, Claus Sandrine P, Fuentes Susana, Puylaert Philippe GB, Neyrinck Audrey M, Bindels Laure B, de Vos Willem M, Gibson Glenn R, Thissen Jean-Paul, Delzenne Nathalie M, Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women, 10.1136/gutjnl-2012-303304
  55. Wu Gary D, Lewis James D, Hoffmann Christian, Chen Ying-Yu, Knight Rob, Bittinger Kyle, Hwang Jennifer, Chen Jun, Berkowsky Ronald, Nessel Lisa, Li Hongzhe, Bushman Frederic D, Sampling and pyrosequencing methods for characterizing bacterial communities in the human gut using 16S sequence tags, 10.1186/1471-2180-10-206
  56. Caporaso J Gregory, Kuczynski Justin, Stombaugh Jesse, Bittinger Kyle, Bushman Frederic D, Costello Elizabeth K, Fierer Noah, Peña Antonio Gonzalez, Goodrich Julia K, Gordon Jeffrey I, Huttley Gavin A, Kelley Scott T, Knights Dan, Koenig Jeremy E, Ley Ruth E, Lozupone Catherine A, McDonald Daniel, Muegge Brian D, Pirrung Meg, Reeder Jens, Sevinsky Joel R, Turnbaugh Peter J, Walters William A, Widmann Jeremy, Yatsunenko Tanya, Zaneveld Jesse, Knight Rob, QIIME allows analysis of high-throughput community sequencing data, 10.1038/nmeth.f.303
  57. Letunic I., Bork P., Interactive Tree Of Life v2: online annotation and display of phylogenetic trees made easy, 10.1093/nar/gkr201
Bibliographic reference Everard, Amandine ; Geurts, Lucie ; Caesar, Robert ; Van Hul, Matthias ; Matamoros, Sébastien ; et. al. Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status. In: Nature Communications, Vol. 5, no. 1, p. 5648 [1-12] (2014)
Permanent URL http://hdl.handle.net/2078.1/156590