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Preparation and studies of the co-crystals of meloxicam with carboxylic acids

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Myz, S.A. Shakhtshneider, T.P. Tumanov, Nikolay [UCL] Boldyreva, E.V.

Mechanical treatment with addition of some liquid, crystallization from solutions, and heating of the mixture components preliminary subjected to mechanical treatment were the methods used for the preparation of the co-crystals of 4-hydroxy-2-methyl-N-(5-methylthiazol-2-yl)-2H-1,2-benzothiazin- 3-carboxamide 1,1-dioxide (meloxicam) with carboxylic acids. It was shown that preliminary mechanical treatment plays significant role for the synthesis, whereas the addition of small amounts of solvents accelerates the process. The co-crystals were obtained for 17 mixtures of meloxicam - carboxylic acid. The use of the co-crystals of meloxicam in the compositions of improved pharmaceutical forms was found promising, which was attributable to the fact that the dissolution rate and the solubility of the co-crystals of meloxicam with the carboxylic acids under study are higher than those for meloxicam itself. © 2012 Springer Science+Business Media New York.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2012
Language Anglais
Journal information "Russian Chemical Bulletin" - Vol. 61, no.9, p. 1798-1809 (2012)
Peer reviewed yes
Publisher Springer New York LLC ((United States) New York)
issn 1066-5285
e-issn 1573-9171
Publication status Publié
Affiliation Institute of solid State Chemistry and Mechanochemistry - Reactivity of solids
Keywords Carboxylic acids ; Co-crystals ; Mechanochemical synthesis ; Meloxicam ; Solubilization of medicines
Links
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Bibliographic reference Myz, S.A. ; Shakhtshneider, T.P. ; Tumanov, Nikolay ; Boldyreva, E.V.. Preparation and studies of the co-crystals of meloxicam with carboxylic acids. In: Russian Chemical Bulletin, Vol. 61, no.9, p. 1798-1809 (2012)
Permanent URL http://hdl.handle.net/2078/154379