User menu

Renaissance of antibiotics against difficult infections: Focus on oritavancin and new ketolides and quinolones.

Bibliographic reference Van Bambeke, Françoise. Renaissance of antibiotics against difficult infections: Focus on oritavancin and new ketolides and quinolones.. In: Annals of medicine, Vol. 46, no. 7, p. 512-529 (2014)
Permanent URL http://hdl.handle.net/2078.1/153982
  1. Boucher H. W., Talbot G. H., Benjamin D. K., Bradley J., Guidos R. J., Jones R. N., Murray B. E., Bonomo R. A., Gilbert D., , 10 x '20 Progress--Development of New Drugs Active Against Gram-Negative Bacilli: An Update From the Infectious Diseases Society of America, 10.1093/cid/cit152
  2. Gould Ian M., Bal Abhijit M., New antibiotic agents in the pipeline and how they can help overcome microbial resistance, 10.4161/viru.22507
  3. de Souza Mendes Cristina, de Souza Antunes Adelaide, Pipeline of Known Chemical Classes of Antibiotics, 10.3390/antibiotics2040500
  4. Van Bambeke Fran??oise, Van Laethem Yves, Courvalin Patrice, Tulkens Paul M, Glycopeptide Antibiotics : from Conventional Molecules to New Derivatives, 10.2165/00003495-200464090-00001
  5. Edelsberg John, Weycker Derek, Barron Rich, Li Xiaoyan, Wu Hongsheng, Oster Gerry, Badre Sejal, Langeberg Wendy J., Weber David J., Prevalence of antibiotic resistance in US hospitals, 10.1016/j.diagmicrobio.2013.11.011
  6. Jones Ronald N., Flonta Mirela, Gurler Nazahat, Cepparulo Mario, Mendes Rodrigo E., Castanheira Mariana, Resistance surveillance program report for selected European nations (2011), 10.1016/j.diagmicrobio.2013.10.008
  7. Jones Ronald N., Guzman-Blanco Manuel, Gales Ana C., Gallegos Belisario, Castro Aura Lucia Leal, Martino Marines Dalla Valle, Vega Silvio, Zurita Jeannete, Cepparulo Mario, Castanheira Mariana, Susceptibility rates in Latin American nations: report from a regional resistance surveillance program (2011), 10.1016/j.bjid.2013.07.002
  8. Zhanel George G., Adam Heather J., Low Donald E., Blondeau Joseph, DeCorby Melanie, Karlowsky James A., Weshnoweski Barbara, Vashisht Ravi, Wierzbowski Aleksandra, Hoban Daryl J., Antimicrobial susceptibility of 15,644 pathogens from Canadian hospitals: results of the CANWARD 2007–2009 study, 10.1016/j.diagmicrobio.2010.10.025
  9. Molton James S., Tambyah Paul A., Ang Brenda S. P., Ling Moi Lin, Fisher Dale A., The Global Spread of Healthcare-Associated Multidrug-Resistant Bacteria: A Perspective From Asia, 10.1093/cid/cit020
  10. Limbago B. M., Kallen A. J., Zhu W., Eggers P., McDougal L. K., Albrecht V. S., Report of the 13th Vancomycin-Resistant Staphylococcus aureus Isolate from the United States, 10.1128/jcm.02187-13
  11. Foucault M.-L., Courvalin P., Grillot-Courvalin C., Fitness Cost of VanA-Type Vancomycin Resistance in Methicillin-Resistant Staphylococcus aureus, 10.1128/aac.01702-08
  12. Kelley Peter G., Gao Wei, Ward Peter B., Howden Benjamin P., Daptomycin non-susceptibility in vancomycin-intermediate Staphylococcus aureus (VISA) and heterogeneous-VISA (hVISA): implications for therapy after vancomycin treatment failure, 10.1093/jac/dkr066
  13. van Hal S. J., Lodise T. P., Paterson D. L., The Clinical Significance of Vancomycin Minimum Inhibitory Concentration in Staphylococcus aureus Infections: A Systematic Review and Meta-analysis, 10.1093/cid/cir935
  14. Beauregard D. A., Williams D. H., Gwynn M. N., Knowles D. J., Dimerization and membrane anchors in extracellular targeting of vancomycin group antibiotics, 10.1128/aac.39.3.781
  15. Nicas T I, Cole C T, Preston D A, Schabel A A, Nagarajan R, Activity of glycopeptides against vancomycin-resistant gram-positive bacteria., 10.1128/aac.33.9.1477
  16. COOPER ROBIN D. G., SNYDER NANCY J., ZWEIFEL MARK J., STASZAK MICHAEL A., WILKIE STEPHEN C., NICAS THALIA I., MULLEN DEBORAH L., BUTLER THOMAS F., RODRIGUEZ MICHAEL J., HUFF BRET E., THOMPSON RICHARD C., Reductive Alkylation of Glycopeptide Antibiotics: Synthesis and Antibacterial Activity., 10.7164/antibiotics.49.575
  17. Morrissey I., Seifert H., Canton R., Nordmann P., Stefani S., MacGowan A., Janes R., Knight D., , Activity of oritavancin against methicillin-resistant staphylococci, vancomycin-resistant enterococci and  -haemolytic streptococci collected from western European countries in 2011, 10.1093/jac/dks344
  18. Mendes R. E., Sader H. S., Flamm R. K., Farrell D. J., Jones R. N., Oritavancin Activity against Staphylococcus aureus Causing Invasive Infections in U.S. and European Hospitals: a 5-Year International Surveillance Program, 10.1128/aac.02482-13
  19. Zhanel George G., Schweizer Frank, Karlowsky James A., Oritavancin: Mechanism of Action, 10.1093/cid/cir920
  20. Belley A., McKay G. A., Arhin F. F., Sarmiento I., Beaulieu S., Fadhil I., Parr T. R., Moeck G., Oritavancin Disrupts Membrane Integrity of Staphylococcus aureus and Vancomycin-Resistant Enterococci To Effect Rapid Bacterial Killing, 10.1128/aac.00760-10
  21. Domenech Oscar, Dufrêne Yves F., Van Bambeke Françoise, Tukens Paul M., Mingeot-Leclercq Marie-Paule, Interactions of oritavancin, a new semi-synthetic lipoglycopeptide, with lipids extracted from Staphylococcus aureus, 10.1016/j.bbamem.2010.06.011
  22. Belley A., Neesham-Grenon E., McKay G., Arhin F. F., Harris R., Beveridge T., Parr T. R., Moeck G., Oritavancin Kills Stationary-Phase and Biofilm Staphylococcus aureus Cells In Vitro, 10.1128/aac.00766-08
  23. Van Bambeke F., Carryn S., Seral C., Chanteux H., Tyteca D., Mingeot-Leclercq M.-P., Tulkens P. M., Cellular Pharmacokinetics and Pharmacodynamics of the Glycopeptide Antibiotic Oritavancin (LY333328) in a Model of J774 Mouse Macrophages, 10.1128/aac.48.8.2853-2860.2004
  24. Garcia L. G., Lemaire S., Kahl B. C., Becker K., Proctor R. A., Denis O., Tulkens P. M., Van Bambeke F., Pharmacodynamic Evaluation of the Activity of Antibiotics against Hemin- and Menadione-Dependent Small-Colony Variants of Staphylococcus aureus in Models of Extracellular (Broth) and Intracellular (THP-1 Monocytes) Infections, 10.1128/aac.00285-12
  25. Nguyen H. A., Denis O., Vergison A., Theunis A., Tulkens P. M., Struelens M. J., Van Bambeke F., Intracellular Activity of Antibiotics in a Model of Human THP-1 Macrophages Infected by a Staphylococcus aureus Small-Colony Variant Strain Isolated from a Cystic Fibrosis Patient: Pharmacodynamic Evaluation and Comparison with Isogenic Normal-Phenotype and Revertant Strains, 10.1128/aac.01145-08
  26. Bambeke Françoise Van, Glycopeptides in clinical development: pharmacological profile and clinical perspectives, 10.1016/j.coph.2004.04.006
  27. Allen Norris, From Vancomycin to Oritavancin: The Discovery and Development of a Novel Lipoglycopeptide Antibiotic, 10.2174/187152110790886745
  28. Van Bambeke F., Saffran J., Mingeot-Leclercq M.-P., Tulkens P. M., Mixed-Lipid Storage Disorder Induced in Macrophages and Fibroblasts by Oritavancin (LY333328), a New Glycopeptide Antibiotic with Exceptional Cellular Accumulation, 10.1128/aac.49.5.1695-1700.2005
  29. Lemaire S., Mingeot-Leclercq M.-P., Tulkens P. M., Van Bambeke F., Study of Macrophage Functions in Murine J774 Cells and Human Activated THP-1 Cells Exposed to Oritavancin, a Lipoglycopeptide with High Cellular Accumulation, 10.1128/aac.02475-13
  30. Baquir Beverlie, Lemaire Sandrine, Van Bambeke Françoise, Tulkens Paul M., Lin Lin, Spellberg Brad, Macrophage Killing of Bacterial and Fungal Pathogens Is Not Inhibited by Intense Intracellular Accumulation of the Lipoglycopeptide Antibiotic Oritavancin, 10.1093/cid/cir921
  31. Ambrose P. G., Drusano G. L., Craig W. A., In Vivo Activity of Oritavancin in Animal Infection Models and Rationale for a New Dosing Regimen in Humans, 10.1093/cid/cis001
  32. Belley A., Arhin F. F., Sarmiento I., Deng H., Rose W., Moeck G., Pharmacodynamics of a Simulated Single 1,200-Milligram Dose of Oritavancin in an In Vitro Pharmacokinetic/Pharmacodynamic Model of Methicillin-Resistant Staphylococcus aureus Infection, 10.1128/aac.01428-12
  33. Dunbar L. M., Milata J., McClure T., Wasilewski M. M., , Comparison of the Efficacy and Safety of Oritavancin Front-Loaded Dosing Regimens to Daily Dosing: an Analysis of the SIMPLIFI Trial, 10.1128/aac.00029-11
  34. Tice A., Oritavancin: A New Opportunity for Outpatient Therapy of Serious Infections, 10.1093/cid/cir1047
  35. Van Bambeke Françoise, Harms Joerg M, Van Laethem Yves, Tulkens Paul M, Ketolides: pharmacological profile and rational positioning in the treatment of respiratory tract infections, 10.1517/14656566.9.2.267
  36. Link-Gelles Ruth, Thomas Ann, Lynfield Ruth, Petit Sue, Schaffner William, Harrison Lee, Farley Monica M., Aragon Deborah, Nicols Megin, Kirley Pam Daily, Zansky Shelley, Jorgensen James, Juni Billie Anne, Jackson Delois, Moore Matthew R., Lipsitch Marc, Geographic and Temporal Trends in Antimicrobial Nonsusceptibility in Streptococcus pneumoniae in the Post-vaccine era in the United States, 10.1093/infdis/jit315
  37. Kim S. H., Song J.-H., Chung D. R., Thamlikitkul V., Yang Y., Wang H., Lu M., So T. M.-k., Hsueh P.-R., Yasin R. M., Carlos C. C., Pham H. V., Lalitha M. K., Shimono N., Perera J., Shibl A. M., Baek J. Y., Kang C.-I., Ko K. S., Peck K. R., , Changing Trends in Antimicrobial Resistance and Serotypes of Streptococcus pneumoniae Isolates in Asian Countries: an Asian Network for Surveillance of Resistant Pathogens (ANSORP) Study, 10.1128/aac.05658-11
  38. European Center for Disease Prevention and Control. Antimicrobial resistance surveillance in Europe - 2012 report. Stockholm, Sweden: European Centre for Disease Prevention and Control; 2013. p. 1–218.
  39. Chisholm S. A., Neal T. J., Alawattegama A. B., Birley H. D. L., Howe R. A., Ison C. A., Emergence of high-level azithromycin resistance in Neisseria gonorrhoeae in England and Wales, 10.1093/jac/dkp188
  40. Pond M. J., Nori A. V., Witney A. A., Lopeman R. C., Butcher P. D., Sadiq S. T., High Prevalence of Antibiotic-Resistant Mycoplasma genitalium in Nongonococcal Urethritis: The Need for Routine Testing and the Inadequacy of Current Treatment Options, 10.1093/cid/cit752
  41. Douthwaite S., Champney W. S., Structures of ketolides and macrolides determine their mode of interaction with the ribosomal target site, 10.1093/jac/48.suppl_2.1
  42. Zhanel George G, Hisanaga Tamiko, Nichol Kim, Wierzbowski Aleksandra, Hoban Daryl J, Ketolides: an emerging treatment for macrolide-resistant respiratory infections, focusing on S. pneumoniae, 10.1517/14728214.8.2.297
  43. Bertrand D., Bertrand S., Neveu E., Fernandes P., Molecular Characterization of Off-Target Activities of Telithromycin: a Potential Role for Nicotinic Acetylcholine Receptors, 10.1128/aac.00840-10
  44. Van Bambeke Françoise, Macrolides and Ketolides, Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics (2014) ISBN:9780387756127 p.257-278, 10.1007/978-0-387-75613-4_11
  45. English M. L., Fredericks C. E., Milanesio N. A., Rohowsky N., Xu Z.-Q., Jenta T. R. J., Flavin M. T., Eiznhamer D. A., Cethromycin versus Clarithromycin for Community-Acquired Pneumonia: Comparative Efficacy and Safety Outcomes from Two Double-Blinded, Randomized, Parallel-Group, Multicenter, Multinational Noninferiority Studies, 10.1128/aac.05596-11
  46. Sato T., Tateda K., Kimura S., Iwata M., Ishii Y., Yamaguchi K., In Vitro Antibacterial Activity of Modithromycin, a Novel 6,11-Bridged Bicyclolide, against Respiratory Pathogens, Including Macrolide-Resistant Gram-Positive Cocci, 10.1128/aac.01469-10
  47. Sato T., Kawai Y., Matsuda H., Tateda K., Kimura S., Ishii Y., Yamaguchi K., Gotoh N., In vitro and in vivo antibacterial activity of modithromycin against streptococci and Haemophilus influenzae, 10.1093/jac/dkr161
  48. Maglio Dana, Sun Heather K., Patel Toral, Banevicius Mary Anne, Nightingale Charles H., Arya Anu, Wang Guoqiang, Chen Zhigang, Phan Ly T., Nicolau David P., Pharmacodynamic profiling of modithromycin: Assessment in a pneumococcal murine pneumonia model, 10.1016/j.ijantimicag.2014.01.029
  49. Llano-Sotelo B., Dunkle J., Klepacki D., Zhang W., Fernandes P., Cate J. H. D., Mankin A. S., Binding and Action of CEM-101, a New Fluoroketolide Antibiotic That Inhibits Protein Synthesis, 10.1128/aac.00860-10
  50. Lemaire S., Van Bambeke F., Tulkens P. M., Cellular Accumulation and Pharmacodynamic Evaluation of the Intracellular Activity of CEM-101, a Novel Fluoroketolide, against Staphylococcus aureus, Listeria monocytogenes, and Legionella pneumophila in Human THP-1 Macrophages, 10.1128/aac.00203-09
  51. Rodvold K. A., Gotfried M. H., Still J. G., Clark K., Fernandes P., Comparison of Plasma, Epithelial Lining Fluid, and Alveolar Macrophage Concentrations of Solithromycin (CEM-101) in Healthy Adult Subjects, 10.1128/aac.00766-12
  52. Still J. G., Schranz J., Degenhardt T. P., Scott D., Fernandes P., Gutierrez M. J., Clark K., Pharmacokinetics of Solithromycin (CEM-101) after Single or Multiple Oral Doses and Effects of Food on Single-Dose Bioavailability in Healthy Adult Subjects, 10.1128/aac.01429-10
  53. Farrell David J., Sader Helio S., Castanheira Mariana, Biedenbach Douglas J., Rhomberg Paul R., Jones Ronald N., Antimicrobial characterisation of CEM-101 activity against respiratory tract pathogens, including multidrug-resistant pneumococcal serogroup 19A isolates, 10.1016/j.ijantimicag.2010.01.026
  54. Putnam Shannon D., Sader Helio S., Farrell David J., Biedenbach Douglas J., Castanheira Mariana, Antimicrobial characterisation of solithromycin (CEM-101), a novel fluoroketolide: activity against staphylococci and enterococci, 10.1016/j.ijantimicag.2010.08.021
  55. Roblin P. M., Kohlhoff S. A., Parker C., Hammerschlag M. R., In Vitro Activity of CEM-101, a New Fluoroketolide Antibiotic, against Chlamydia trachomatis and Chlamydia (Chlamydophila) pneumoniae, 10.1128/aac.01343-09
  56. Mallegol J, Antimicrob Agents Chemother (2013)
  57. Olsen Birgitta, Lan Pham Thi, Golparian Daniel, Johansson Emma, Khang Tran Hau, Unemo Magnus, Antimicrobial susceptibility and genetic characteristics of Neisseria gonorrhoeae isolates from Vietnam, 2011, 10.1186/1471-2334-13-40
  58. Golparian D., Fernandes P., Ohnishi M., Jensen J. S., Unemo M., In Vitro Activity of the New Fluoroketolide Solithromycin (CEM-101) against a Large Collection of Clinical Neisseria gonorrhoeae Isolates and International Reference Strains, Including Those with High-Level Antimicrobial Resistance: Potential Treatment Option for Gonorrhea?, 10.1128/aac.00036-12
  59. Jensen J. S., Fernandes P., Unemo M., In Vitro Activity of the New Fluoroketolide Solithromycin (CEM-101) against Macrolide-Resistant and -Susceptible Mycoplasma genitalium Strains, 10.1128/aac.02411-14
  60. Waites K. B., Crabb D. M., Duffy L. B., Comparative In Vitro Susceptibilities of Human Mycoplasmas and Ureaplasmas to a New Investigational Ketolide, CEM-101, 10.1128/aac.00090-09
  61. Vandevelde N. M., Tulkens P. M., Van Bambeke F., Antibiotic Activity against Naive and Induced Streptococcus pneumoniae Biofilms in an In Vitro Pharmacodynamic Model, 10.1128/aac.01858-13
  62. Oldach D., Clark K., Schranz J., Das A., Craft J. C., Scott D., Jamieson B. D., Fernandes P., Randomized, Double-Blind, Multicenter Phase 2 Study Comparing the Efficacy and Safety of Oral Solithromycin (CEM-101) to Those of Oral Levofloxacin in the Treatment of Patients with Community-Acquired Bacterial Pneumonia, 10.1128/aac.00197-13
  63. Emami S, Ir J Pharm Res, 4, 123 (2005)
  64. Van Bambeke F., Michot J.-M., Van Eldere J., Tulkens P.M., Quinolones in 2005: an update, 10.1111/j.1469-0691.2005.01131.x
  65. Walsh Christopher T, Wencewicz Timothy A, Prospects for new antibiotics: a molecule-centered perspective, 10.1038/ja.2013.49
  66. Sousa J, Curr Drug Saf
  67. Stein G. E., Goldstein E. J. C., Fluoroquinolones and Anaerobes, 10.1086/503907
  68. Van Bambeke Françoise, Tulkens Paul M., Safety Profile of the Respiratory Fluoroquinolone Moxifloxacin : Comparison with Other Fluoroquinolones and Other Antibacterial Classes, 10.2165/00002018-200932050-00001
  69. Drlica K, Microbiol Mol Biol Rev, 61, 377 (1997)
  70. Munoz-Bellido JL, Antimicrob Agents Chemother, 43, 354 (1999)
  71. Costa Sofia, Falcão Celeste, Viveiros Miguel, Machado Diana, Martins Marta, Melo-Cristino José, Amaral Leonard, Couto Isabel, Exploring the contribution of efflux on the resistance to fluoroquinolones in clinical isolates of Staphylococcus aureus, 10.1186/1471-2180-11-241
  72. Alam Mohammed Mahbub, Kobayashi Nobumichi, Uehara Nobuyuki, Watanabe Naoki, Analysis on Distribution and Genomic Diversity of High-Level Antiseptic Resistance GenesqacAandqacBin Human Clinical Isolates ofStaphylococcus aureus, 10.1089/107662903765826697
  73. Marumo K., Detection of OXA-4 beta-lactamase in Pseudomonas aeruginosa isolates by genetic methods, 10.1093/jac/43.2.187
  74. Garvey M. I., Baylay A. J., Wong R. L., Piddock L. J. V., Overexpression of patA and patB, Which Encode ABC Transporters, Is Associated with Fluoroquinolone Resistance in Clinical Isolates of Streptococcus pneumoniae, 10.1128/aac.00672-10
  75. Lismond A., Carbonnelle S., Tulkens P. M., Van Bambeke F., Efflux of novel quinolones in contemporary Streptococcus pneumoniae isolates from community-acquired pneumonia, 10.1093/jac/dkr004
  76. Schmitz F. J., Fluit A. C., Luckefahr M., Engler B., Hofmann B., Verhoef J., Heinz H. P., Hadding U., Jones M. E., The effect of reserpine, an inhibitor of multidrug efflux pumps, on the in-vitro activities of ciprofloxacin, sparfloxacin and moxifloxacin against clinical isolates of Staphylococcus aureus, 10.1093/jac/42.6.807
  77. Van Bambeke F., Antibiotic efflux pumps in prokaryotic cells: occurrence, impact on resistance and strategies for the future of antimicrobial therapy, 10.1093/jac/dkg224
  78. Lomovskaya O, Antimicrob Agents Chemother, 43, 1340 (1999)
  79. Tran J. H., Jacoby G. A., Mechanism of plasmid-mediated quinolone resistance, 10.1073/pnas.082092899
  80. Robicsek Ari, Strahilevitz Jacob, Jacoby George A, Macielag Mark, Abbanat Darren, Hye Park Chi, Bush Karen, Hooper David C, Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase, 10.1038/nm1347
  81. Dalhoff A., Resistance surveillance studies: a multifaceted problem—the fluoroquinolone example, 10.1007/s15010-012-0257-2
  82. Dalhoff A, Interdiscip Perspect Infect Dis, 2012, 976273 (2012)
  83. TITELMAN EMILIA, IVERSEN AINA, KAHLMETER GUNNAR, GISKE CHRISTIAN G., Antimicrobial susceptibility to parenteral and oral agents in a largely polyclonal collection of CTX-M-14 and CTX-M-15-producing Escherichia coli and Klebsiella pneumoniae : ESBL AND ANTIMICROBIAL SUSCEPTIBILITY, 10.1111/j.1600-0463.2011.02766.x
  84. Van Heirstraeten L., Leten G., Lammens C., Goossens H., Malhotra-Kumar S., Increase in fluoroquinolone non-susceptibility among clinical Streptococcus pyogenes in Belgium during 2007-10, 10.1093/jac/dks281
  85. Lemaire Sandrine, Van Bambeke Françoise, Tulkens Paul M., Activity of finafloxacin, a novel fluoroquinolone with increased activity at acid pH, towards extracellular and intracellular Staphylococcus aureus, Listeria monocytogenes and Legionella pneumophila, 10.1016/j.ijantimicag.2011.03.002
  86. Higgins P. G., Stubbings W., Wisplinghoff H., Seifert H., Activity of the Investigational Fluoroquinolone Finafloxacin against Ciprofloxacin-Sensitive and -Resistant Acinetobacter baumannii Isolates, 10.1128/aac.01637-09
  87. Emrich Nadine-C., Heisig Anke, Stubbings Will, Labischinski Harald, Heisig Peter, Antibacterial activity of finafloxacin under different pH conditions against isogenic strains of Escherichia coli expressing combinations of defined mechanisms of fluoroquinolone resistance, 10.1093/jac/dkq375
  88. Stubbings W., Leow P., Yong G. C., Goh F., Korber-Irrgang B., Kresken M., Endermann R., Labischinski H., In Vitro Spectrum of Activity of Finafloxacin, a Novel, pH-Activated Fluoroquinolone, under Standard and Acidic Conditions, 10.1128/aac.00833-10
  89. Dalhoff A., Stubbings W., Schubert S., Comparative In Vitro Activities of the Novel Antibacterial Finafloxacin against Selected Gram-Positive and Gram-Negative Bacteria Tested in Mueller-Hinton Broth and Synthetic Urine, 10.1128/aac.00886-10
  90. Patel H., Andresen A., Vente A., Heilmann H.-D., Stubbings W., Seiberling M., Lopez-Lazaro L., Pokorny R., Labischinski H., Human Pharmacokinetics and Safety Profile of Finafloxacin, a New Fluoroquinolone Antibiotic, in Healthy Volunteers, 10.1128/aac.00832-10
  91. Jacobs M.R., Optimisation of antimicrobial therapy using pharmacokinetic and pharmacodynamic parameters, 10.1046/j.1198-743x.2001.00295.x
  92. Biedenbach Douglas J., Farrell David J., Flamm Robert K., Liverman Lisa C., McIntyre Gail, Jones Ronald N., Activity of JNJ-Q2, a new fluoroquinolone, tested against contemporary pathogens isolated from patients with community-acquired bacterial pneumonia, 10.1016/j.ijantimicag.2011.11.016
  93. Biedenbach Douglas J., Turner Lisa L., Jones Ronald N., Farrell David J., Activity of JNJ-Q2, a novel fluoroquinolone, tested against Neisseria gonorrhoeae, including ciprofloxacin-resistant strains, 10.1016/j.diagmicrobio.2012.06.006
  94. Eichenbaum G, Pugsley MK, Gallacher DJ, Towart R, McIntyre G, Shukla U, Davenport JM, Lu HR, Rohrbacher J, Hillsamer V, Role of mixed ion channel effects in the cardiovascular safety assessment of the novel anti-MRSA fluoroquinolone JNJ-Q2 : Role of ion channels in the CV safety of JNJ-Q2, 10.1111/j.1476-5381.2012.01874.x
  95. Davenport J. M., Covington P., Gotfried M., Medlock M., Watanalumlerd P., McIntyre G., Turner L., Almenoff J., Summary of Pharmacokinetics and Tissue Distribution of a Broad-Spectrum Fluoroquinolone, JNJ-Q2, 10.1177/2160763x12454714
  96. Covington P. S., Davenport J. M., Andrae D. A., Stryjewski M. E., Turner L. L., McIntyre G., Almenoff J., A Phase 2 study of the novel fluoroquinolone JNJ-Q2 in community-acquired bacterial pneumonia, 10.1093/jac/dkt217
  97. Park Hee Soo, Jung Sung Ji, Kwak Jin-Hwan, Choi Dong-Rack, Choi Eung-Chil, DNA gyrase and topoisomerase IV are dual targets of zabofloxacin in Streptococcus pneumoniae, 10.1016/j.ijantimicag.2010.02.022
  98. Park H.-S., Kim H.-J., Seol M.-J., Choi D.-R., Choi E.-C., Kwak J.-H., In Vitro and In Vivo Antibacterial Activities of DW-224a, a New Fluoronaphthyridone, 10.1128/aac.01407-05
  99. Jones Ronald N., Biedenbach Douglas J., Ambrose Paul G., Wikler Matthew A., Zabofloxacin (DW-224a) activity against Neisseria gonorrhoeae including quinolone-resistant strains, 10.1016/j.diagmicrobio.2008.05.010
  100. Han HyeKyung, Kim Sung Eun, Shin Kwang-Hee, Lim Cheolhee, Lim Kyoung Soo, Yu Kyung-Sang, Cho Joo-Youn, Comparison of pharmacokinetics between new quinolone antibiotics: the zabofloxacin hydrochloride capsule and the zabofloxacin aspartate tablet, 10.1185/03007995.2013.825591
  101. Adam H. J., Laing N. M., King C. R., Lulashnyk B., Hoban D. J., Zhanel G. G., In Vitro Activity of Nemonoxacin, a Novel Nonfluorinated Quinolone, against 2,440 Clinical Isolates, 10.1128/aac.00078-09
  102. Chotikanatis K., Kohlhoff S. A., Hammerschlag M. R., In Vitro Activity of Nemonoxacin, a Novel Nonfluorinated Quinolone Antibiotic, against Chlamydia trachomatis and Chlamydia pneumoniae, 10.1128/aac.02263-13
  103. Liao C.-H., Ko W.-C., Lu J.-J., Hsueh P.-R., Characterizations of Clinical Isolates of Clostridium difficile by Toxin Genotypes and by Susceptibility to 12 Antimicrobial Agents, Including Fidaxomicin (OPT-80) and Rifaximin: a Multicenter Study in Taiwan, 10.1128/aac.00191-12
  104. Lin L., Chang L.-W., Tsai C.-Y., Hsu C.-H., Chung D. T., Aronstein W. S., Ajayi F., Kuzmak B., Lyon R. A., Dose Escalation Study of the Safety, Tolerability, and Pharmacokinetics of Nemonoxacin (TG-873870), a Novel Potent Broad-Spectrum Nonfluorinated Quinolone, in Healthy Volunteers, 10.1128/aac.00682-09
  105. Chung D. T., Tsai C.-Y., Chen S.-J., Chang L.-W., King C.-H. R., Hsu C.-H., Chiu K.-M., Tan H.-C., Chang Y.-T., Hsu M.-C., Multiple-Dose Safety, Tolerability, and Pharmacokinetics of Oral Nemonoxacin (TG-873870) in Healthy Volunteers, 10.1128/aac.00683-09
  106. Liang W., Chen Y.-c., Cao Y.-r., Liu X.-f., Huang J., Hu J.-l., Zhao M., Guo Q.-l., Zhang S.-j., Wu X.-j., Zhu D.-m., Zhang Y.-y., Zhang J., Pharmacokinetics and Pharmacodynamics of Nemonoxacin against Streptococcus pneumoniae in an In Vitro Infection Model, 10.1128/aac.01098-12
  107. Wright D. H., Application of fluoroquinolone pharmacodynamics, 10.1093/jac/46.5.669
  108. van Rensburg D. J. J., Perng R.-P., Mitha I. H., Bester A. J., Kasumba J., Wu R.-G., Ho M.-L., Chang L.-W., Chung D. T., Chang Y.-T., King C.-H. R., Hsu M.-C., Efficacy and Safety of Nemonoxacin versus Levofloxacin for Community-Acquired Pneumonia, 10.1128/aac.00295-10
  109. Lemaire S., Tulkens P. M., Van Bambeke F., Contrasting Effects of Acidic pH on the Extracellular and Intracellular Activities of the Anti-Gram-Positive Fluoroquinolones Moxifloxacin and Delafloxacin against Staphylococcus aureus, 10.1128/aac.01201-10
  110. Drlica K., Zhao X., Mutant Selection Window Hypothesis Updated, 10.1086/511642
  111. Remy J. M., Tow-Keogh C. A., McConnell T. S., Dalton J. M., DeVito J. A., Activity of delafloxacin against methicillin-resistant Staphylococcus aureus: resistance selection and characterization, 10.1093/jac/dks307
  112. Bauer J., Siala W., Tulkens P. M., Van Bambeke F., A Combined Pharmacodynamic Quantitative and Qualitative Model Reveals the Potent Activity of Daptomycin and Delafloxacin against Staphylococcus aureus Biofilms, 10.1128/aac.00181-13
  113. , White Paper: Recommendations on the Conduct of Superiority and Organism-Specific Clinical Trials of Antibacterial Agents for the Treatment of Infections Caused by Drug-Resistant Bacterial Pathogens, 10.1093/cid/cis688
  114. Saravolatz Louis D., Pawlak Joan, Johnson Leonard B., In vitro activity of oritavancin against community-associated meticillin-resistant Staphylococcus aureus (CA-MRSA), vancomycin-intermediate S. aureus (VISA), vancomycin-resistant S. aureus (VRSA) and daptomycin-non-susceptible S. aureus (DNSSA), 10.1016/j.ijantimicag.2010.02.023
  115. Arhin F. F., Draghi D. C., Pillar C. M., Parr T. R., Moeck G., Sahm D. F., Comparative In Vitro Activity Profile of Oritavancin against Recent Gram-Positive Clinical Isolates, 10.1128/aac.00952-09
  116. Farrell David J., Castanheira Mariana, Sader Helio S., Jones Ronald N., The in vitro evaluation of solithromycin (CEM-101) against pathogens isolated in the United States and Europe (2009), 10.1016/j.jinf.2010.08.010
  117. Andrews J. M., The in vitro activity of ABT773, a new ketolide antimicrobial agent, 10.1093/jac/46.6.1017
  118. Luna V. A., Xu Z.-Q., Eiznhamer D. A., Cannons A. C., Cattani J., Susceptibility of 170 isolates of the USA300 clone of MRSA to macrolides, clindamycin and the novel ketolide cethromycin, 10.1093/jac/dkn227
  119. Arhin F. F., Sarmiento I., Parr T. R., Moeck G., Comparative in vitro activity of oritavancin against Staphylococcus aureus strains that are resistant, intermediate or heteroresistant to vancomycin, 10.1093/jac/dkp286
  120. Chen Y.-H., Liu C.-Y., Lu J.-J., King C.-H. R., Hsueh P.-R., In vitro activity of nemonoxacin (TG-873870), a novel non-fluorinated quinolone, against clinical isolates of Staphylococcus aureus, enterococci and Streptococcus pneumoniae with various resistance phenotypes in Taiwan, 10.1093/jac/dkp370
  121. Singh K. V., Malathum K., Murray B. E., In Vitro Activities of a New Ketolide, ABT-773, against Multidrug-Resistant Gram-Positive Cocci, 10.1128/aac.45.12.3640-3643.2001
  122. Lauderdale T.-L., Shiau Y.-R., Lai J.-F., Chen H.-C., King C.-H. R., Comparative In Vitro Activities of Nemonoxacin (TG-873870), a Novel Nonfluorinated Quinolone, and Other Quinolones against Clinical Isolates, 10.1128/aac.01197-09
  123. Farrell D. J., Liverman L. C., Biedenbach D. J., Jones R. N., JNJ-Q2, a New Fluoroquinolone with Potent In Vitro Activity against Staphylococcus aureus, Including Methicillin- and Fluoroquinolone-Resistant Strains, 10.1128/aac.00162-11
  124. Kwon A.-R., In vitro and in vivo activities of DW-224a, a novel fluoroquinolone antibiotic agent, 10.1093/jac/dkl304
  125. Morrow B. J., He W., Amsler K. M., Foleno B. D., Macielag M. J., Lynch A. S., Bush K., In Vitro Antibacterial Activities of JNJ-Q2, a New Broad-Spectrum Fluoroquinolone, 10.1128/aac.01374-09
  126. Mendes R. E., Woosley L. N., Farrell D. J., Sader H. S., Jones R. N., Oritavancin Activity against Vancomycin-Susceptible and Vancomycin-Resistant Enterococci with Molecularly Characterized Glycopeptide Resistance Genes Recovered from Bacteremic Patients, 2009-2010, 10.1128/aac.06067-11
  127. Kosowska-Shick K., Credito K., Pankuch G. A., Lin G., Bozdogan B., McGhee P., Dewasse B., Choi D.-R., Ryu J. M., Appelbaum P. C., Antipneumococcal Activity of DW-224a, a New Quinolone, Compared to Those of Eight Other Agents, 10.1128/aac.00153-06
  128. McGhee P., Clark C., Kosowska-Shick K. M., Nagai K., Dewasse B., Beachel L., Appelbaum P. C., In Vitro Activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with Defined Macrolide Resistance Mechanisms, 10.1128/aac.01123-09