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The course of anaemia in children and adolescents with Crohn's disease included in a prospective registry.

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van Biervliet, Stephanie Smets, Françoise [UCL] Hofmann, Ilse Degreef, Elisabeth Hauser, Bruno Rahier, Jean-François [UCL] Veereman, Gigi

Aim The aim of this study is to determine the prevalence and evolution of anaemia in prospectively followed children and adolescents diagnosed with Crohn’s disease (CD). Methods The BELCRO registry (inclusion May 2008–April 2010), describing current clinical treatment practice of children diagnosed with CD, provided data on age, height, body mass index (BMI), paediatric Crohn’s disease activity index (PCDAI), therapy and haemoglobin (Hb) at diagnosis 12 and 24 months follow-up. Anaemia was defined as Hb < −2 sd, while severe anaemia was defined as Hb < −4 sd. Patients were classified as child ≤13 and adolescent >13 years of age. Result Ninety-six were included, 13 dropped out due to insufficient Hb data (37 females/46 males; median age 13.3 years, range 2.2–17.8 years). At diagnosis, the median Hb sd was −2.66 (−8.4; 1.07) and was correlated with the PCDAI (p = 0.013). At diagnosis, 51/83 (61 %) were anaemic and all had active disease. Hb z-score significantly improved (p < 0.0001) but 26/68 (38 %) remained anaemic at 12 months and 29/76 (38 %) at 24 months of follow-up. The correlation to the PCDAI disappeared. At 24 months, children were more likely to be anaemic. There was no difference in iron dose nor duration of iron supplements between children and adolescents. Iron treatment was more readily given to patients presenting with anaemia. Hb did not differ between patients with (n = 28) or without iron supplements. Half of the patients with persisting anaemia were given iron supplements, of which, only three were given intravenously. Conclusion Anaemia remains an important extra-intestinal manifestation of CD in children. Physicians, lacking optimal treatment strategies, undertreat their patients.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2015
Language Anglais
Journal information "International Journal of Colorectal Disease : clinical and molecular gastroenterology and surgery" - Vol. 30, no. 1, p. pp 51-56 (2015)
Peer reviewed yes
Publisher Springer ((Germany) Heidelberg)
issn 0179-1958
e-issn 1432-1262
Publication status Publié
Affiliations UCL - (SLuc) Service de gastro-entérologie et hépatologie pédiatrique
UCL - SSS/IREC/PEDI - Pôle de Pédiatrie
UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie
UCL - (MGD) Service de gastro-entérologie
Links
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Bibliographic reference van Biervliet, Stephanie ; Smets, Françoise ; Hofmann, Ilse ; Degreef, Elisabeth ; Hauser, Bruno ; et. al. The course of anaemia in children and adolescents with Crohn's disease included in a prospective registry.. In: International Journal of Colorectal Disease : clinical and molecular gastroenterology and surgery, Vol. 30, no. 1, p. pp 51-56 (2015)
Permanent URL http://hdl.handle.net/2078.1/152113