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New reference tables and user-friendly Internet application for predicted heart weights

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Vanhaebost, Jessica [UCL] Faouzi, Mohamed Mangin, Patrice Michaud, Katarzyna

BACKGROUND: Knowledge of normal heart weight ranges is important information for pathologists. Comparing the measured heart weight to reference values is one of the key elements used to determine if the heart is pathological, as heart weight increases in many cardiac pathologies. The current reference tables are old and in need of an update. AIMS: The purposes of this study are to establish new reference tables for normal heart weights in the local population and to determine the best predictive factor for normal heart weight. We also aim to provide technical support to calculate the predictive normal heart weight. METHODS: The reference values are based on retrospective analysis of adult Caucasian autopsy cases without any obvious pathology that were collected at the University Centre of Legal Medicine in Lausanne from 2007 to 2011. We selected 288 cases. The mean age was 39.2 years. There were 118 men and 170 women. Regression analyses were performed to assess the relationship of heart weight to body weight, body height, body mass index (BMI) and body surface area (BSA). RESULTS: The heart weight increased along with an increase in all the parameters studied. The mean heart weight was greater in men than in women at a similar body weight. BSA was determined to be the best predictor for normal heart weight. New reference tables for predicted heart weights are presented as a web application that enable the comparison of heart weights observed at autopsy with the reference values. CONCLUSIONS: The reference tables for heart weight and other organs should be systematically updated and adapted for the local population. Web access and smartphone applications for the predicted heart weight represent important investigational tools.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2014
Language Anglais
Journal information "International journal of legal medicine" - Vol. 128, no. 4, p. 615-620 (2014)
Peer reviewed yes
Publisher Springer International ((Germany) Heidelberg)
issn 0937-9827
e-issn 1437-1596
Publication status Publié
Affiliation UCL - (SLuc) Service d'anatomie pathologique
Keywords Heart weight ; Autopsy ; Reference table ; Smartphone application
Links
  1. Arnold HD (1899) Weight of the "normal" heart in adults. J Boston Soc Med Sci 3(6):174–184
  2. S.K. DADGAR, S.P. TYAGI, R.P. SINGH, S. HAMEED, FACTORS INFLUENCING THE NORMAL HEART WEIGHT : A STUDY OF 140 HEARTS, 10.1253/jcj.43.77
  3. da Cunha DF, de Carvalho da Cunha SF, dos Reis MA, de Paula Antunes Teixeira V (2002) Heart weight and heart weight/body weight coefficient in malnourished adults. Arq Bras Cardiol 78(4):385–387
  4. de la Grandmaison Geoffroy Lorin, Clairand Isabelle, Durigon Michel, Organ weight in 684 adult autopsies: new tables for a Caucasoid population, 10.1016/s0379-0738(00)00401-1
  5. Gray H., Mahan Eleanor, Prediction of heart weight in man, 10.1002/ajpa.1330010311
  6. Hanzlick Randy, Rydzewski David, Heart Weights of White Men 20 to 39 Years of Age : An Analysis of 218 Autopsy Cases, 10.1097/00000433-199009000-00005
  7. Hayes JA, Lovell HG (1966) Heart weight of Jamaicans: autopsy study of normal cases and cases of hypertension and chronic lung disease. Am Heart Assoc 33:450–454
  8. He Q., Heshka S., Albu J., Boxt L., Krasnow N., Elia M., Gallagher D., Smaller organ mass with greater age, except for heart, 10.1152/japplphysiol.90454.2008
  9. Seo Joong Seok, Lee Sang Yong, Won Kyung Joon, Kim Dae Joong, Sohn Dong Seup, Yang Ki Min, Cho Sang Ho, Park Jung Duck, Lee Kyung Hoon, Kim Ho Dirk, Relationship between normal heart size and body indices in Korean, 10.3346/jkms.2000.15.6.641
  10. KITZMAN DALANE W., SCHOLZ DAVID G., HAGEN PHILIP T., ILSTRUP DUANE M., EDWARDS WILLIAM D., Age-Related Changes in Normal Human Hearts During the First 10 Decades of Life. Part II (Maturity): A Quantitative Anatomic Study of 765 Specimens From Subjects 20 to 99 Years Old, 10.1016/s0025-6196(12)64946-5
  11. Molina D. Kimberley, DiMaio Vincent J.M., Normal Organ Weights in Men : Part I—The Heart, 10.1097/paf.0b013e31823d298b
  12. Ogiu Nobuko, Nakamura Yuji, Ijiri Iwao, Hiraiwa Kouichi, Ogiu Toshiaki, A Statistical Analysis of the Internal Organ Weights of Normal Japanese People : , 10.1097/00004032-199703000-00004
  13. Reiner L, Mazzoleni A, Rodriguez FL, Freudenthal RR (1959) The weight of the human heart. I. Normal cases. AMA Arch Pathol 68(1):58–73
  14. Smith HL (1928) The relation of the weight of the heart to the weight of the heart to age. Am Heart J 4(1):79–93. doi: 10.1016/s0002-8703(29)90099-5
  15. Zeek PM (1942) Heart weight. I. The weight of the normal human heart. Arch Pathol 34:820–832
  16. Smith Harry L., The relation of the weight of the heart to the weight of the body and of the weight of the heart to age, 10.1016/s0002-8703(29)90099-5
  17. Gaitskell K., Perera R., Soilleux E. J., Derivation of new reference tables for human heart weights in light of increasing body mass index, 10.1136/jcp.2010.084574
  18. Lucas S. B., 'Derivation of new reference tables for human heart weights in light of increasing body mass index', 10.1136/jcp.2010.085902
  19. Brinkmann B., Harmonisation of Medico-Legal Autopsy Rules, 10.1007/s004140050271
  20. Reiner L, Mazzoleni A, Rodriguez FL (1955) Statistical analysis of the epicardial fat weight in human hearts. AMA Arch Pathol 60(4):369–373
  21. Boyd E (1935) The growth of the surface area of the human body. University of Minnesota. The Institute of Child Welfare, Monograph Series, No. x. London: Oxford University Press
  22. Virtanen A, Kairisto V, Irjala K, Rajamäki A, Uusipaikka E (1998) Regression-based reference limits and their reliability: example on hemoglobin during the first year of life. Clin Chem 44(2):327–335
  23. StataCorp (2011) Stata statistical software: release 12. StataCorp LP, College Station
  24. Garby L., Lammert O., Kock K. F., Thobo-Carlsen B., Weights of brain, heart, liver, kidneys, and spleen in healthy and apparently healthy adult Danish subjects, 10.1002/ajhb.1310050307
  25. Hitosugi Masahito, Takatsu Akihiro, Kinugasa Yasuo, Takao Hiroyuki, Estimation of normal heart weight in Japanese subjects: development of a simplified normal heart weight scale, 10.1016/s1344-6223(99)80017-0
  26. Kim Y-S, Kim D-I, Cho SY, Kim MH, Yang KM, Lee HY, Han S-H (2009) Statistical analysis for organ weights in Korean adult autopsies. Korean J Anat 42(4):219–224
  27. Sheikhazadi Ardeshir, Sadr Seyed Shahabeddin, Ghadyani Mohammad Hasan, Taheri Seyed Kazem, Manouchehri Ali Asghar, Nazparvar Bashir, Mehrpour Omid, Ghorbani Mazaher, Study of the normal internal organ weights in Tehran’s population, 10.1016/j.jflm.2009.07.012
Bibliographic reference Vanhaebost, Jessica ; Faouzi, Mohamed ; Mangin, Patrice ; Michaud, Katarzyna. New reference tables and user-friendly Internet application for predicted heart weights. In: International journal of legal medicine, Vol. 128, no. 4, p. 615-620 (2014)
Permanent URL http://hdl.handle.net/2078.1/151555