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Use of cidofovir in HPV patients with recurrent respiratory papillomatosis.

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Grasso, M Remacle, Marc [UCL] Bachy, Vincent [UCL] Van der Vorst, Sébastien [UCL] Lawson, Georges [UCL]

Recurrent respiratory papillomatosis is a viral-induced disease, associated with exophytic epithelial lesions affecting the upper airways. Problem of treatment is the high recurrence of papilloma growth after surgical removal; therefore, adjuvant therapy schemes have been established. We used cidofovir, 7.5 mg/ml, in adjuvant therapy in the past years. Out of 31 adult patients treated with the drug, 26 (83.9 %) are at the moment in complete response. 19 (73 % of pts with CR) of those 26 patients were cured with a number of injections between 1 and 4 (mean 2.5). We did not see any clinical manifestation of renal toxicity or neutropenia (superinfection) necessitating a blood test. Six patients presented dysplasia during the treatment with the drug, while six patients had dysplasia prior to cidofovir injection. Due to recurrent nature of the disease and the high number of mechanical and laser surgeries required we treated one tracheal stenosis, two scarred larynx, and two glottic synechiaes. There is still an ongoing discussion within the European Laryngological Society about the effectiveness and possible side effects of this drug. Results show promising long-term effects of adjuvant use of cidofovir, without any relevant side effects.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2014
Language Anglais
Journal information "European Archives of Oto-Rhino-Laryngology" - Vol. 271, no. 11, p. 2983-2990 (2014)
Peer reviewed yes
Publisher Springer ((Germany) Heidelberg)
issn 0937-4477
e-issn 1434-4726
Publication status Publié
Affiliations UCL - SSS/IREC/MONT - Pôle Mont Godinne
UCL - (MGD) Service d'oto-rhino-laryngologie
UCL - SSS/IREC/CARS - Computer Assisted Robotic Surgery
UCL - SSS/IREC/LUNS - Pôle pneumologie, ORL (airways) et dermatologie (skin)
Links
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Bibliographic reference Grasso, M ; Remacle, Marc ; Bachy, Vincent ; Van der Vorst, Sébastien ; Lawson, Georges. Use of cidofovir in HPV patients with recurrent respiratory papillomatosis.. In: European Archives of Oto-Rhino-Laryngology, Vol. 271, no. 11, p. 2983-2990 (2014)
Permanent URL http://hdl.handle.net/2078.1/146562