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Stem cell bioprocess engineering towards cGMP production and clinical applications

Bibliographic reference Sart, Sébastien ; Schneider, Yves-Jacques ; Li, Yan ; Agathos, Spiros N.. Stem cell bioprocess engineering towards cGMP production and clinical applications. In: Cytotechnology : international journal of cell culture and biotechnology, Vol. 66, no. 5, p. 709-722 (2014)
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  1. Abbasalizadeh Saeed, Baharvand Hossein, Technological progress and challenges towards cGMP manufacturing of human pluripotent stem cells based therapeutic products for allogeneic and autologous cell therapies, 10.1016/j.biotechadv.2013.08.009
  2. Abranches Elsa, Bekman Evguenia, Henrique Domingos, Cabral Joaquim M.S., Expansion of mouse embryonic stem cells on microcarriers, 10.1002/bit.21191
  3. Alfred Roz, Gareau Tia, Krawetz Roman, Rancourt Derrick, Kallos Michael S., Serum-free scaled up expansion and differentiation of murine embryonic stem cells to osteoblasts in suspension bioreactors, 10.1002/bit.22727
  4. Alper Joe, Geron gets green light for human trial of ES cell–derived product, 10.1038/nbt0309-213a
  5. Augello A, Kurth TB, De Bari C (2010) Mesenchymal stem cells: a perspective from in vitro cultures to in vivo migration and niches. Eur Cell Mater 20:121–133
  6. Baker Duncan E C, Harrison Neil J, Maltby Edna, Smith Kath, Moore Harry D, Shaw Pamela J, Heath Paul R, Holden Hazel, Andrews Peter W, Adaptation to culture of human embryonic stem cells and oncogenesis in vivo, 10.1038/nbt1285
  7. Bardy Jo'an, Chen Allen K., Lim Yu Ming, Wu Selena, Wei Shunhui, Weiping Han, Chan Ken, Reuveny Shaul, Oh Steve K.W., Microcarrier Suspension Cultures for High-Density Expansion and Differentiation of Human Pluripotent Stem Cells to Neural Progenitor Cells, 10.1089/ten.tec.2012.0146
  8. Bhang Suk Ho, Cho Seung-Woo, La Wan-Geun, Lee Tae-Jin, Yang Hee Seok, Sun Ah-Young, Baek Sang-Hong, Rhie Jong-Won, Kim Byung-Soo, Angiogenesis in ischemic tissue produced by spheroid grafting of human adipose-derived stromal cells, 10.1016/j.biomaterials.2010.12.035
  9. Bieberich Erhard, MacKinnon Sarah, Silva Jeane, Noggle Scott, Condie Brian G., Regulation of cell death in mitotic neural progenitor cells by asymmetric distribution of prostate apoptosis response 4 (PAR-4) and simultaneous elevation of endogenous ceramide, 10.1083/jcb.200212067
  10. Blum Barak, Benvenisty Nissim, The tumorigenicity of diploid and aneuploid human pluripotent stem cells, 10.4161/cc.8.23.10067
  11. Bongso Ariff, Fong Chui-Yee, Gauthaman Kalamegam, Taking stem cells to the clinic: Major challenges, 10.1002/jcb.21957
  12. Bratt-Leal Andrés M., Carpenedo Richard L., McDevitt Todd C., Engineering the embryoid body microenvironment to direct embryonic stem cell differentiation, 10.1002/btpr.139
  13. Bratt-Leal Andrés M., Carpenedo Richard L., Ungrin Mark D., Zandstra Peter W., McDevitt Todd C., Incorporation of biomaterials in multicellular aggregates modulates pluripotent stem cell differentiation, 10.1016/j.biomaterials.2010.08.113
  14. Caplan Arnold I., Dennis James E., Mesenchymal stem cells as trophic mediators, 10.1002/jcb.20886
  15. Carpenter Melissa K, Frey-Vasconcells Joyce, Rao Mahendra S, Developing safe therapies from human pluripotent stem cells, 10.1038/nbt0709-606
  16. Chen Xiaoli, Chen Allen, Woo Tsung Liang, Choo Andre B.H., Reuveny Shaul, Oh Steve K.W., Investigations into the Metabolism of Two-Dimensional Colony and Suspended Microcarrier Cultures of Human Embryonic Stem Cells in Serum-Free Media, 10.1089/scd.2010.0077
  17. Chen Guokai, Gulbranson Daniel R, Hou Zhonggang, Bolin Jennifer M, Ruotti Victor, Probasco Mitchell D, Smuga-Otto Kimberly, Howden Sara E, Diol Nicole R, Propson Nicholas E, Wagner Ryan, Lee Garrett O, Antosiewicz-Bourget Jessica, Teng Joyce M C, Thomson James A, Chemically defined conditions for human iPSC derivation and culture, 10.1038/nmeth.1593
  18. Cimetta Elisa, Sirabella Dario, Yeager Keith, Davidson Kathryn, Simon Joseph, Moon Randall T., Vunjak-Novakovic Gordana, Microfluidic bioreactor for dynamic regulation of early mesodermal commitment in human pluripotent stem cells, 10.1039/c2lc40836h
  19. Cuiffo Benjamin G., Karnoub Antoine E., Mesenchymal stem cells in tumor development : Emerging roles and concepts, 10.4161/cam.20875
  20. Diogo Maria Margarida, da Silva Cláudia Lobato, Cabral Joaquim M.S., Separation technologies for stem cell bioprocessing, 10.1002/bit.24706
  21. Dos Santos F, Andrade PZ, Boura JS, Abecasis MM, da Silva CL, Cabral JM (2010) Ex vivo expansion of human mesenchymal stem cells: a more effective cell proliferation kinetics and metabolism under hypoxia. J Cell Physiol 223:27–35
  22. Dressel Ralf, Effects of histocompatibility and host immune responses on the tumorigenicity of pluripotent stem cells, 10.1007/s00281-011-0266-8
  23. FDA, Guidance for FDA reviewers and sponsors (2008) Content and review of chemistry, manufacturing, and control (CMC) information for human gene therapy investigational new drug applications (INDs).
  24. Ferreira Lino, Squier Trevor, Park Hyoungshin, Choe Hannah, Kohane Daniel S., Langer Robert, Human Embryoid Bodies Containing Nano- and Microparticulate Delivery Vehicles, 10.1002/adma.200702404
  25. Fluri David A, Tonge Peter D, Song Hannah, Baptista Ricardo P, Shakiba Nika, Shukla Shreya, Clarke Geoffrey, Nagy Andras, Zandstra Peter W, Derivation, expansion and differentiation of induced pluripotent stem cells in continuous suspension cultures, 10.1038/nmeth.1939
  26. Fong Chui-Yee, Gauthaman Kalamegam, Bongso Ariff, Teratomas from pluripotent stem cells: A clinical hurdle, 10.1002/jcb.22775
  27. Fridley Krista M., Fernandez Irina, Li Mon-Tzu Alice, Kettlewell Robert B., Roy Krishnendu, Unique Differentiation Profile of Mouse Embryonic Stem Cells in Rotary and Stirred Tank Bioreactors, 10.1089/ten.tea.2010.0166
  28. Frith Jessica E., Thomson Brian, Genever Paul G., Dynamic Three-Dimensional Culture Methods Enhance Mesenchymal Stem Cell Properties and Increase Therapeutic Potential, 10.1089/ten.tec.2009.0432
  29. Gao L, McBeath R, Chen CS (2010) Stem cell shape regulates a chondrogenic versus myogenic fate through Rac1 and N-cadherin. Stem Cells 28:564–572
  30. Gareau Tia, Lara Giovanna G., Shepherd Robert D., Krawetz Roman, Rancourt Derrick E., Rinker Kristina D., Kallos Michael S., Shear stress influences the pluripotency of murine embryonic stem cells in stirred suspension bioreactors : Bioreactor shear stress influences mESC pluripotency, 10.1002/term.1518
  31. Godara Pankaj, McFarland Clive D, Nordon Robert E, Design of bioreactors for mesenchymal stem cell tissue engineering, 10.1002/jctb.1918
  32. Goh Tony Kwang-Poh, Zhang Zhi-Yong, Chen Allen Kuan-Liang, Reuveny Shaul, Choolani Mahesh, Chan Jerry Kok Yen, Oh Steve Kah-Weng, Microcarrier Culture for Efficient Expansion and Osteogenic Differentiation of Human Fetal Mesenchymal Stem Cells, 10.1089/biores.2013.0001
  33. Gonçalves Alexandra, Costa Pedro, Rodrigues Márcia T., Dias Isabel R., Reis Rui L., Gomes Manuela E., Effect of flow perfusion conditions in the chondrogenic differentiation of bone marrow stromal cells cultured onto starch based biodegradable scaffolds, 10.1016/j.actbio.2010.11.044
  34. Griffin Matthew D., Ritter Thomas, Mahon Bernard P., Immunological Aspects of Allogeneic Mesenchymal Stem Cell Therapies, 10.1089/hum.2010.156
  35. Grinnemo Karl-Henrik, Sylvén Christer, Hovatta Outi, Dellgren Göran, Corbascio Matthias, Immunogenicity of human embryonic stem cells, 10.1007/s00441-007-0486-3
  36. HARA K, YASUHARA T, MAKI M, MATSUKAWA N, MASUDA T, YU S, ALI M, YU G, XU L, KIM S, Neural progenitor NT2N cell lines from teratocarcinoma for transplantation therapy in stroke, 10.1016/j.pneurobio.2008.04.005
  37. Hedlund Eva, Pruszak Jan, Lardaro Thomas, Ludwig Wesley, Viñuela Angel, Kim Kwang-Soo, Isacson Ole, Embryonic Stem Cell-Derived Pitx3-Enhanced Green Fluorescent Protein Midbrain Dopamine Neurons Survive Enrichment by Fluorescence-Activated Cell Sorting and Function in an Animal Model of Parkinson's Disease, 10.1634/stemcells.2007-0996
  38. Heng Tracy S. P., Dudakov Jarrod A., Khong Danika M. P., Chidgey Ann P., Boyd Richard L., Stem cells—meet immunity, 10.1007/s00109-009-0539-z
  39. Horwitz E. M., Gordon P. L., Koo W. K. K., Marx J. C., Neel M. D., McNall R. Y., Muul L., Hofmann T., Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone, 10.1073/pnas.132252399
  40. Hou P., Li Y., Zhang X., Liu C., Guan J., Li H., Zhao T., Ye J., Yang W., Liu K., Ge J., Xu J., Zhang Q., Zhao Y., Deng H., Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds, 10.1126/science.1239278
  41. Huang C-Y C., Effects of Cyclic Compressive Loading on Chondrogenesis of Rabbit Bone-Marrow Derived Mesenchymal Stem Cells, 10.1634/stemcells.22-3-313
  42. Hwang D-Y, Kim D-S, Kim D-W (2010) Human ES and iPS cells as cell sources for the treatment of Parkinson’s disease: current state and problems. J Cell Biochem 109:292–301
  43. Kabiri Mahboubeh, Kul Betul, Lott William B., Futrega Kathryn, Ghanavi Parisa, Upton Zee, Doran Michael R., 3D mesenchymal stem/stromal cell osteogenesis and autocrine signalling, 10.1016/j.bbrc.2012.01.017
  44. Kaiser Stephan, Jossen Valentin, Schirmaier Carmen, Eibl Dieter, Brill Silke, van den Bos Christian, Eibl Regine, Fluid Flow and Cell Proliferation of Mesenchymal Adipose-Derived Stem Cells in Small-Scale, Stirred, Single-Use Bioreactors, 10.1002/cite.201200180
  45. King James A, Miller William M, Bioreactor development for stem cell expansion and controlled differentiation, 10.1016/j.cbpa.2007.05.034
  46. Knoepfler Paul S., Deconstructing Stem Cell Tumorigenicity: A Roadmap to Safe Regenerative Medicine, 10.1002/stem.37
  47. Kreke Michelle R., Sharp Lindsay A., Woo Lee Yong, Goldstein Aaron S., Effect of Intermittent Shear Stress on Mechanotransductive Signaling and Osteoblastic Differentiation of Bone Marrow Stromal Cells, 10.1089/tea.2007.0068
  48. Lazennec Gwendal, Jorgensen Christian, Concise Review: Adult Multipotent Stromal Cells and Cancer: Risk or Benefit?, 10.1634/stemcells.2007-1006
  49. Lecina Marti, Ting Sherwin, Choo Andre, Reuveny Shaul, Oh Steve, Scalable Platform for Human Embryonic Stem Cell Differentiation to Cardiomyocytes in Suspended Microcarrier Cultures, 10.1089/ten.tec.2010.0104
  50. Lennon Donald P., Haynesworth Stephen E., Young Randell G., Dennis James E., Caplan Arnold I., A Chemically Defined Medium Supports in Vitro Proliferation and Maintains the Osteochondral Potential of Rat Marrow-Derived Mesenchymal Stem Cells, 10.1006/excr.1995.1221
  51. Leung Hau Wan, Chen Allen, Choo Andre B.H., Reuveny Shaul, Oh Steve K.W., Agitation can Induce Differentiation of Human Pluripotent Stem Cells in Microcarrier Cultures, 10.1089/ten.tec.2010.0320
  52. Li Yan, Kniss Douglas A., Lasky Larry C., Yang Shang-Tian, 10.1023/a:1024283521966
  53. Li Deqiang, Tang Tingting, Lu Jianxi, Dai Kerong, Effects of Flow Shear Stress and Mass Transport on the Construction of a Large-Scale Tissue-Engineered Bone in a Perfusion Bioreactor, 10.1089/ten.tea.2008.0540
  54. Li Yan, Gautam Archna, Yang Jiwei, Qiu Liqun, Melkoumian Zara, Weber Jennifer, Telukuntla Lavanya, Srivastava Rashi, Whiteley Erik M., Brandenberger Ralph, Differentiation of Oligodendrocyte Progenitor Cells from Human Embryonic Stem Cells on Vitronectin-Derived Synthetic Peptide Acrylate Surface, 10.1089/scd.2012.0508
  55. Liu Liyue, Yuan Wenji, Wang Jinfu, Mechanisms for osteogenic differentiation of human mesenchymal stem cells induced by fluid shear stress, 10.1007/s10237-010-0206-x
  56. Liu Ning, Zang Ru, Yang Shang-Tian, Li Yan, Stem cell engineering in bioreactors for large-scale bioprocessing, 10.1002/elsc.201300013
  57. Lo Ting, Ho Jennifer H., Yang Muh-Hwa, Lee Oscar K., Glucose Reduction Prevents Replicative Senescence and Increases Mitochondrial Respiration in Human Mesenchymal Stem Cells, 10.3727/096368910x539100
  58. Lovett Michael, Rockwood Danielle, Baryshyan Amanda, Kaplan David L., Simple Modular Bioreactors for Tissue Engineering: A System for Characterization of Oxygen Gradients, Human Mesenchymal Stem Cell Differentiation, and Prevascularization, 10.1089/ten.tec.2010.0241
  59. Lutolf Matthias P., Blau Helen M., Artificial Stem Cell Niches, 10.1002/adma.200802582
  60. Mandenius Carl-Fredrik, Steel Daniella, Noor Fozia, Meyer Thomas, Heinzle Elmar, Asp Julia, Arain Sarina, Kraushaar Udo, Bremer Susanne, Class Reiner, Sartipy Peter, Cardiotoxicity testing using pluripotent stem cell-derived human cardiomyocytes and state-of-the-art bioanalytics: a review : Cardiotoxicity testing using derived stem cells, 10.1002/jat.1663
  61. Martín Patricia Gálvez, Martinez Adolfina Ruiz, Lara Visitación Gallardo, Naveros Beatriz Clares, Regulatory considerations in production of a cell therapy medicinal product in Europe to clinical research, 10.1007/s10238-012-0213-6
  62. Massard C, Deutsch E, Soria J-C, Tumour stem cell-targeted treatment: elimination or differentiation, 10.1093/annonc/mdl074
  63. McBeath Rowena, Pirone Dana M, Nelson Celeste M, Bhadriraju Kiran, Chen Christopher S, Cell Shape, Cytoskeletal Tension, and RhoA Regulate Stem Cell Lineage Commitment, 10.1016/s1534-5807(04)00075-9
  64. Meyers Valerie E, Zayzafoon Majd, Douglas Joanne T, McDonald Jay M, RhoA and Cytoskeletal Disruption Mediate Reduced Osteoblastogenesis and Enhanced Adipogenesis of Human Mesenchymal Stem Cells in Modeled Microgravity, 10.1359/jbmr.050611
  65. Niebruegge Sylvia, Bauwens Céline L., Peerani Raheem, Thavandiran Nimalan, Masse Stephane, Sevaptisidis Elias, Nanthakumar Kumar, Woodhouse Kim, Husain Mansoor, Kumacheva Eugenia, Zandstra Peter W., Generation of human embryonic stem cell-derived mesoderm and cardiac cells using size-specified aggregates in an oxygen-controlled bioreactor, 10.1002/bit.22065
  66. Oh Steve K. W., Choo Andre B. H., Human Embryonic Stem Cell Technology: Large Scale Cell Amplification and Differentiation, 10.1007/s10616-005-3862-4
  67. Okamoto Oswaldo, Carvalho Ana Carolina SR, Marti Luciana C, Vêncio Ricardo Z, Moreira-Filho Carlos A, Common molecular pathways involved in human CD133+/CD34+ progenitor cell expansion and cancer, 10.1186/1475-2867-7-11
  68. Outten Joel T., Cheng Xin, Gadue Paul, French Deborah L., Diamond Scott L., A high-throughput multiplexed screening assay for optimizing serum-free differentiation protocols of human embryonic stem cells, 10.1016/j.scr.2010.11.001
  69. Peerani Raheem, Onishi Kento, Mahdavi Alborz, Kumacheva Eugenia, Zandstra Peter W., Manipulation of Signaling Thresholds in “Engineered Stem Cell Niches” Identifies Design Criteria for Pluripotent Stem Cell Screens, 10.1371/journal.pone.0006438
  70. Pittenger M. F., Multilineage Potential of Adult Human Mesenchymal Stem Cells, 10.1126/science.284.5411.143
  71. Przybyla L. M., Voldman J., Attenuation of extrinsic signaling reveals the importance of matrix remodeling on maintenance of embryonic stem cell self-renewal, 10.1073/pnas.1103100109
  72. Ratcliffe E., Thomas R. J., Williams D. J., Current understanding and challenges in bioprocessing of stem cell-based therapies for regenerative medicine, 10.1093/bmb/ldr037
  73. Ratcliffe Elizabeth, Hourd Paul, Guijarro-Leach Juan, Rayment Erin, Williams David J, Thomas Robert J, Application of response surface methodology to maximize the productivity of scalable automated human embryonic stem cell manufacture, 10.2217/rme.12.109
  74. Rodriguez Rene, Rubio Ruth, Menendez Pablo, Modeling sarcomagenesis using multipotent mesenchymal stem cells, 10.1038/cr.2011.157
  75. Sargent Carolyn Y., Berguig Geoffrey Y., McDevitt Todd C., Cardiomyogenic Differentiation of Embryoid Bodies Is Promoted by Rotary Orbital Suspension Culture, 10.1089/ten.tea.2008.0145
  76. Sart Sébastien, Schneider Yves-Jacques, Agathos Spiros N., Influence of culture parameters on ear mesenchymal stem cells expanded on microcarriers, 10.1016/j.jbiotec.2010.08.003
  77. Sart Sébastien, Errachid Abdelmounaim, Schneider Yves-Jacques, Agathos Spiros N., Modulation of mesenchymal stem cell actin organization on conventional microcarriers for proliferation and differentiation in stirred bioreactors : Actin regulates MSC propagation and differentiation on microcarriers, 10.1002/term.545
  78. Sart Sébastien, Ma Teng, Li Yan, Cryopreservation of pluripotent stem cell aggregates in defined protein-free formulation, 10.1002/btpr.1653
  79. Sart Sébastien, Agathos Spiros N., Li Yan, Engineering stem cell fate with biochemical and biomechanical properties of microcarriers, 10.1002/btpr.1825
  80. Sart Sébastien, Tsai Ang-Chen, Li Yan, Ma Teng, Three-Dimensional Aggregates of Mesenchymal Stem Cells: Cellular Mechanisms, Biological Properties, and Applications, 10.1089/ten.teb.2013.0537
  81. Scadden David T., The stem-cell niche as an entity of action, 10.1038/nature04957
  82. Schop D., van Dijkhuizen-Radersma R., Borgart E., Janssen F. W., Rozemuller H., Prins H-J., de Bruijn J. D., Expansion of human mesenchymal stromal cells on microcarriers: growth and metabolism, 10.1002/term.224
  83. Schwartz Steven D, Hubschman Jean-Pierre, Heilwell Gad, Franco-Cardenas Valentina, Pan Carolyn K, Ostrick Rosaleen M, Mickunas Edmund, Gay Roger, Klimanskaya Irina, Lanza Robert, Embryonic stem cell trials for macular degeneration: a preliminary report, 10.1016/s0140-6736(12)60028-2
  84. Sensebé Luc, Bourin Philippe, Tarte Karin, Good Manufacturing Practices Production of Mesenchymal Stem/Stromal Cells, 10.1089/hum.2010.197
  85. Serra Margarida, Brito Catarina, Sousa Marcos F.Q., Jensen Janne, Tostões Rui, Clemente João, Strehl Raimund, Hyllner Johan, Carrondo Manuel J.T., Alves Paula M., Improving expansion of pluripotent human embryonic stem cells in perfused bioreactors through oxygen control, 10.1016/j.jbiotec.2010.06.015
  86. Serra Margarida, Brito Catarina, Correia Cláudia, Alves Paula M., Process engineering of human pluripotent stem cells for clinical application, 10.1016/j.tibtech.2012.03.003
  87. Sharma Shikha, Raju Ravali, Sui Siguang, Hu Wei-Shou, Stem cell culture engineering - process scale up and beyond, 10.1002/biot.201000435
  88. Shay Jerry W., Wright Woodring E., Telomeres and telomerase in normal and cancer stem cells, 10.1016/j.febslet.2010.05.026
  89. Sheyn Dima, Pelled Gadi, Netanely Dvir, Domany Eytan, Gazit Dan, The Effect of Simulated Microgravity on Human Mesenchymal Stem Cells Cultured in an Osteogenic Differentiation System: A Bioinformatics Study, 10.1089/ten.tea.2009.0834
  90. Shih Yu-Ru V, Tseng Kuo-Fung, Lai Hsiu-Yu, Lin Chi-Hung, Lee Oscar K, Matrix stiffness regulation of integrin-mediated mechanotransduction during osteogenic differentiation of human mesenchymal stem cells, 10.1002/jbmr.278
  91. Simaria Ana S., Hassan Sally, Varadaraju Hemanthram, Rowley Jon, Warren Kim, Vanek Philip, Farid Suzanne S., Allogeneic cell therapy bioprocess economics and optimization: Single-use cell expansion technologies : Allogeneic Cell Therapy Bioprocess Economics, 10.1002/bit.25008
  92. Singh Harmeet, Mok Pamela, Balakrishnan Thavamalar, Rahmat Siti Norfiza Binte, Zweigerdt Robert, Up-scaling single cell-inoculated suspension culture of human embryonic stem cells, 10.1016/j.scr.2010.03.001
  93. Spangrude G. J., Two rare populations of mouse Thy-1lo bone marrow cells repopulate the thymus, 10.1084/jem.167.5.1671
  94. Stadtfeld M., Hochedlinger K., Induced pluripotency: history, mechanisms, and applications, 10.1101/gad.1963910
  95. Stenberg Johan, Elovsson Maria, Strehl Raimund, Kilmare Eva, Hyllner Johan, Lindahl Anders, Sustained embryoid body formation and culture in a non-laborious three dimensional culture system for human embryonic stem cells, 10.1007/s10616-011-9344-y
  96. Storm Michael P., Orchard Craig B., Bone Heather K., Chaudhuri Julian B., Welham Melanie J., Three-dimensional culture systems for the expansion of pluripotent embryonic stem cells, 10.1002/bit.22850
  97. Sun Yubing, Chen Christopher S., Fu Jianping, Forcing Stem Cells to Behave: A Biophysical Perspective of the Cellular Microenvironment, 10.1146/annurev-biophys-042910-155306
  98. Takahashi Kazutoshi, Tanabe Koji, Ohnuki Mari, Narita Megumi, Ichisaka Tomoko, Tomoda Kiichiro, Yamanaka Shinya, Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors, 10.1016/j.cell.2007.11.019
  99. Takehara Masaya, Hoshino Tatsuya, Namba Takushi, Yamakawa Naoki, Mizushima Tohru, Acetaminophen-induced differentiation of human breast cancer stem cells and inhibition of tumor xenograft growth in mice, 10.1016/j.bcp.2011.02.012
  100. Tan Heng Liang, Fong Wey Jia, Lee Eng Hin, Yap Miranda, Choo Andre, mAb 84, a Cytotoxic Antibody that Kills Undifferentiated Human Embryonic Stem Cells via Oncosis, 10.1002/stem.109
  101. Taylor C. J., Bolton E. M., Bradley J. A., Immunological considerations for embryonic and induced pluripotent stem cell banking, 10.1098/rstb.2011.0030
  102. Terstegge Stefanie, Laufenberg Iris, Pochert Jörg, Schenk Sabine, Itskovitz-Eldor Joseph, Endl Elmar, Brüstle Oliver, Automated maintenance of embryonic stem cell cultures, 10.1002/bit.21061
  103. Thomas Robert, Ratcliffe Elizabeth, Automated Adherent Human Cell Culture (Mesenchymal Stem Cells), Methods in Molecular Biology (2012) ISBN:9781617793660 p.393-406, 10.1007/978-1-61779-367-7_26
  104. Thomson J. A., Embryonic Stem Cell Lines Derived from Human Blastocysts, 10.1126/science.282.5391.1145
  105. Unger C., Skottman H., Blomberg P., Sirac Dilber M., Hovatta O., Good manufacturing practice and clinical-grade human embryonic stem cell lines, 10.1093/hmg/ddn079
  106. Wagner Joseph, Kean Thomas, Young Randell, Dennis James E, Caplan Arnold I, Optimizing mesenchymal stem cell-based therapeutics, 10.1016/j.copbio.2009.08.009
  107. Wang Yingjie, Zhang Yunping, Zhang Shichang, Peng Guangyong, Liu Tao, Li Yangxin, Xiang Dedong, Wassler Michael J., Shelat Harnath S., Geng Yongjian, Rotating Microgravity-Bioreactor Cultivation Enhances the Hepatic Differentiation of Mouse Embryonic Stem Cells on Biodegradable Polymer Scaffolds, 10.1089/ten.tea.2012.0097
  108. Watt F. M., Out of Eden: Stem Cells and Their Niches, 10.1126/science.287.5457.1427
  109. Weiss Daniel J., Casaburi Richard, Flannery Robin, LeRoux-Williams Michelle, Tashkin Donald P., A Placebo-Controlled, Randomized Trial of Mesenchymal Stem Cells in COPD, 10.1378/chest.12-2094
  110. Wolfe Russell P., Ahsan Tabassum, Shear stress during early embryonic stem cell differentiation promotes hematopoietic and endothelial phenotypes, 10.1002/bit.24782
  111. Wolfe Russell P., Leleux Jardin, Nerem Robert M., Ahsan Tabassum, Effects of shear stress on germ lineage specification of embryonic stem cells, 10.1039/c2ib20040f
  112. Yirme Galia, Amit Michal, Laevsky Ilana, Osenberg Sivan, Itskovitz-Eldor Joseph, Establishing a Dynamic Process for the Formation, Propagation, and Differentiation of Human Embryoid Bodies, 10.1089/scd.2007.0272
  113. Zhang Zhi-Yong, Teoh Swee Hin, Teo Erin Yiling, Khoon Chong Mark Seow, Shin Chong Woon, Tien Foo Toon, Choolani Mahesh A., Chan Jerry K.Y., A comparison of bioreactors for culture of fetal mesenchymal stem cells for bone tissue engineering, 10.1016/j.biomaterials.2010.07.097
  114. Zhao Tongbiao, Zhang Zhen-Ning, Rong Zhili, Xu Yang, Immunogenicity of induced pluripotent stem cells, 10.1038/nature10135
  115. Zoldan Janet, Karagiannis Emmanouil D., Lee Christopher Y., Anderson Daniel G., Langer Robert, Levenberg Shulamit, The influence of scaffold elasticity on germ layer specification of human embryonic stem cells, 10.1016/j.biomaterials.2011.09.012