User menu

ABCB1 1199G>A genetic polymorphism (Rs2229109) influences the intracellular accumulation of tacrolimus in HEK293 and K562 recombinant cell lines

Bibliographic reference Dessilly, Géraldine ; Elens, Laure ; Panin, Nadtha ; Capron, Arnaud ; Decottignies, Anabelle ; et. al. ABCB1 1199G>A genetic polymorphism (Rs2229109) influences the intracellular accumulation of tacrolimus in HEK293 and K562 recombinant cell lines. In: PLoS One, Vol. 9, no. 3, p. e91555 [1-11] (2014)
Permanent URL
  1. Chin J E, Soffir R, Noonan K E, Choi K, Roninson I B, Structure and expression of the human MDR (P-glycoprotein) gene family., 10.1128/mcb.9.9.3808
  2. Bodor Miklos, Kelley Edward J., Ho Rodney J., Characterization of the humanMDR1 gene, 10.1208/aapsj070101
  3. Fardel Olivier, Lecureur Valérie, Guillouzo André, The P-glycoprotein multidrug transporter, 10.1016/s0306-3623(96)00081-x
  4. Vasiliou Vasilis, Vasiliou Konstandinos, Nebert Daniel W, Human ATP-binding cassette (ABC) transporter family, 10.1186/1479-7364-3-3-281
  5. Choudhuri Supratim, Klaassen Curtis D., Structure, Function, Expression, Genomic Organization, and Single Nucleotide Polymorphisms of Human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) Efflux Transporters, 10.1080/10915810600746023
  6. Szakács Gergely, Váradi András, Özvegy-Laczka Csilla, Sarkadi Balázs, The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicity (ADME–Tox), 10.1016/j.drudis.2007.12.010
  7. Zhou S.-F., Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition, 10.1080/00498250701867889
  8. Beringer Paul M, Slaughter Richard L, Transporters and Their Impact on Drug Disposition, 10.1345/aph.1e614
  9. Sakaeda Toshiyuki, Nakamura Tsutomu, Okumura Katsuhiko, Pharmacogenetics of MDR1 and its impact on the pharmacokinetics and pharmacodynamics of drugs, 10.1517/phgs.4.4.397.22747
  10. Callaghan Richard, Crowley Emily, Biochem M, Potter Simon, Kerr Ian D., P-glycoprotein: So Many Ways to Turn It On, 10.1177/0091270007311568
  11. T Saeki, J Biol Chem, 268, 6077 (1993)
  12. Czyzewski K., Styczynski J., Imatinib is a substrate for various multidrug resistance proteins, 10.4149/neo_2009_03_202
  13. Woodahl Erica L., Crouthamel Matthew H., Bui Tot, Shen Danny D., Ho Rodney J. Y., MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents, 10.1007/s00280-008-0906-4
  14. Lepper Erin R, Nooter Kees, Verweij Jaap, Acharya Milin R, Figg William D, Sparreboom Alex, Mechanisms of resistance to anticancer drugs: the role of the polymorphic ABC transporters ABCB1 and ABCG2, 10.1517/14622416.6.2.115
  15. Gottesman Michael M., Fojo Tito, Bates Susan E., MULTIDRUG RESISTANCE IN CANCER: ROLE OF ATP-DEPENDENT TRANSPORTERS, 10.1038/nrc706
  16. Crouthamel Matthew H., Wu Daniel, Yang Ziping, Ho Rodney J.Y., A Novel MDR1 G1199T Variant Alters Drug Resistance and Efflux Transport Activity of P-Glycoprotein in Recombinant Hek Cells, 10.1002/jps.20743
  17. Cascorbi I, Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects, 10.1067/mcp.2001.114164
  18. YH Li, Yi Chuan Xue Bao, 33, 93 (2006)
  19. Schwab Matthias, Eichelbaum Michel, Fromm Martin F., GENETICPOLYMORPHISMS OF THEHUMANMDR1DRUGTRANSPORTER, 10.1146/annurev.pharmtox.43.100901.140233
  20. Kim R, Identification of functionally variant MDR1 alleles among European Americans and African Americans, 10.1067/mcp.2001.117412
  21. Hoffmeyer S., Burk O., von Richter O., Arnold H. P., Brockmoller J., Johne A., Cascorbi I., Gerloff T., Roots I., Eichelbaum M., Brinkmann U., Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo, 10.1073/pnas.97.7.3473
  22. Haufroid Vincent, Genetic Polymorphisms of ATP-Binding Cassette Transporters ABCB1 and ABCC2 and their Impact on Drug Disposition, 10.2174/138945011795378487
  23. Woodahl E. L., Multidrug Resistance Gene G1199A Polymorphism Alters Efflux Transport Activity of P-Glycoprotein, 10.1124/jpet.104.065383
  24. Woodahl Erica L, Yang Ziping, Bui Tot, Shen Danny D, Ho Rodney JY, MDR1 G1199A polymorphism alters permeability of HIV protease inhibitors across P-glycoprotein-expressing epithelial cells : , 10.1097/01.aids.0000183626.74299.77
  25. Staatz Christine E, Tett Susan E, Clinical Pharmacokinetics and Pharmacodynamics of Tacrolimus in Solid Organ Transplantation : , 10.2165/00003088-200443100-00001
  26. Scott Lesley J, McKeage Kate, Keam Susan J, Plosker Greg L, Tacrolimus : A Further Update of its Use in the Management of Organ Transplantation, 10.2165/00003495-200363120-00006
  27. Jusko William J., Thomson Angus W., Fung John, McMaster Paul, Wong Steven H., Zylber-Katz Ester, Christians Uwe, Winkler Michael, Fitzsimmons William E., Lieberman Ronald, McBride James, Kobayashi Masakazu, Warty Vijay, Soldin Steven J., Consensus Document: Therapeutic Monitoring of Tacrolimus (FK-506) : , 10.1097/00007691-199512000-00011
  28. Wallemacq Pierre, Armstrong Victor W, Brunet Merce, Haufroid Vincent, Holt David W, Johnston Atholl, Kuypers Dirk, Meur Yannick Le, Marquet Pierre, Oellerich Michael, Thervet Eric, Toenshoff Burkhand, Undre Nas, Weber Lutz T, Westley Ian S, Mourad Michel, Opportunities to Optimize Tacrolimus Therapy in Solid Organ Transplantation: Report of the European Consensus Conference : , 10.1097/ftd.0b013e318198d092
  29. Elens Laure, Capron Arnaud, Kerckhove Valérie Van, Lerut Jan, Mourad Michel, Lison Dominique, Wallemacq Pierre, Haufroid Vincent, 1199G>A and 2677G>T/A polymorphisms of ABCB1 independently affect tacrolimus concentration in hepatic tissue after liver transplantation : , 10.1097/fpc.0b013e3282e9a533
  30. Capron Arnaud, Mourad Michel, De Meyer Martine, De Pauw Luc, Eddour Djamila Chaib, Latinne Dominique, Elens Laure, Haufroid Vincent, Wallemacq Pierre, CYP3A5andABCB1polymorphisms influence tacrolimus concentrations in peripheral blood mononuclear cells after renal transplantation, 10.2217/pgs.10.43
  31. Crettol Séverine, Venetz Jean-Pierre, Fontana Massimiliano, Aubert John-David, Ansermot Nicolas, Fathi Marc, Pascual Manuel, Eap Chin B., Influence of ABCB1 genetic polymorphisms on cyclosporine intracellular concentration in transplant recipients : , 10.1097/fpc.0b013e3282f7046f
  32. Elens Laure, Tyteca Donatienne, Panin Nadtha, Courtoy Pierre, Lison Dominique, Demoulin Jean-Baptiste, Haufroid Vincent, Functional defect caused by the 4544G>A SNP in ABCC2 : potential impact for drug cellular disposition, 10.1097/fpc.0b013e32834d672b
  33. CM Vallet, Int J Antimicrob Agents, 38, 249 (2011)
  34. Capron Arnaud, Musuamba Flora, Latinne Dominique, Mourad Michel, Lerut Jan, Haufroid Vincent, Wallemacq Pierre E, Validation of a Liquid Chromatography-Mass Spectrometric Assay for Tacrolimus in Peripheral Blood Mononuclear Cells : , 10.1097/ftd.0b013e3181905aaa
  35. Ueda K., Cardarelli C., Gottesman M. M., Pastan I., Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine., 10.1073/pnas.84.9.3004
  36. Horio M., Gottesman M. M., Pastan I., ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells., 10.1073/pnas.85.10.3580
  37. Cornwell M. M., Safa A. R., Felsted R. L., Gottesman M. M., Pastan I., Membrane vesicles from multidrug-resistant human cancer cells contain a specific 150- to 170-kDa protein detected by photoaffinity labeling., 10.1073/pnas.83.11.3847
  38. Salama Noha N., Yang Ziping, Bui T.o.t., Ho Rodney J.Y., MDR1 haplotypes significantly minimize intracellular uptake and transcellular P‐gp substrate transport in recombinant LLC‐PK1 cells, 10.1002/jps.20717
  39. Cascorbi Ingolf, Role of pharmacogenetics of ATP-binding cassette transporters in the pharmacokinetics of drugs, 10.1016/j.pharmthera.2006.04.009