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Making β cells from adult cells within the pancreas

Bibliographic reference Lysy, Philippe ; Weir, Gordon C ; Bonner-Weir, Susan. Making β cells from adult cells within the pancreas. In: Current diabetes reports, Vol. 13, no.5, p. 695-703 (2013)
Permanent URL http://hdl.handle.net/2078.1/143485
  1. Barton F. B., Rickels M. R., Alejandro R., Hering B. J., Wease S., Naziruddin B., Oberholzer J., Odorico J. S., Garfinkel M. R., Levy M., Pattou F., Berney T., Secchi A., Messinger S., Senior P. A., Maffi P., Posselt A., Stock P. G., Kaufman D. B., Luo X., Kandeel F., Cagliero E., Turgeon N. A., Witkowski P., Naji A., O'Connell P. J., Greenbaum C., Kudva Y. C., Brayman K. L., Aull M. J., Larsen C., Kay T. W. H., Fernandez L. A., Vantyghem M.-C., Bellin M., Shapiro A. M. J., Improvement in Outcomes of Clinical Islet Transplantation: 1999-2010, 10.2337/dc12-0063
  2. Maglione Manuel, Ploeg Rutger J., Friend Peter J., Donor risk factors, retrieval technique, preservation and ischemia/reperfusion injury in pancreas transplantation : , 10.1097/mot.0b013e32835c29ef
  3. Kroon Evert, Martinson Laura A, Kadoya Kuniko, Bang Anne G, Kelly Olivia G, Eliazer Susan, Young Holly, Richardson Mike, Smart Nora G, Cunningham Justine, Agulnick Alan D, D'Amour Kevin A, Carpenter Melissa K, Baetge Emmanuel E, Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo, 10.1038/nbt1393
  4. Rezania A., Bruin J. E., Riedel M. J., Mojibian M., Asadi A., Xu J., Gauvin R., Narayan K., Karanu F., O'Neil J. J., Ao Z., Warnock G. L., Kieffer T. J., Maturation of Human Embryonic Stem Cell-Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice, 10.2337/db11-1711
  5. Schroeder Insa S., Potential of Pluripotent Stem Cells for Diabetes Therapy, 10.1007/s11892-012-0292-5
  6. O'Sullivan Esther S., Vegas Arturo, Anderson Daniel G., Weir Gordon C., Islets Transplanted in Immunoisolation Devices: A Review of the Progress and the Challenges that Remain, 10.1210/er.2010-0026
  7. •• Pan FC, Wright C. Pancreas organogenesis: from bud to plexus to gland. Dev Dyn: Off Publ Am Assoc Anatomists. 2011;240:530–65. Thorough overview of pancreas embryogenesis with insights into molecular and cellular aspects of organ development.
  8. Bar-Nur Ori, Russ Holger A., Efrat Shimon, Benvenisty Nissim, Epigenetic Memory and Preferential Lineage-Specific Differentiation in Induced Pluripotent Stem Cells Derived from Human Pancreatic Islet Beta Cells, 10.1016/j.stem.2011.06.007
  9. Avrahami Dana, Kaestner Klaus H., Epigenetic regulation of pancreas development and function, 10.1016/j.semcdb.2012.06.002
  10. Sokal E. M., From hepatocytes to stem and progenitor cells for liver regenerative medicine: advances and clinical perspectives : Progenitor cells for liver regenerative medicine, 10.1111/j.1365-2184.2010.00730.x
  11. Shapiro A. M. James, State of the Art of Clinical Islet Transplantation and Novel Protocols of Immunosuppression, 10.1007/s11892-011-0217-8
  12. Tan Donald TH, Dart John KG, Holland Edward J, Kinoshita Shigeru, Corneal transplantation, 10.1016/s0140-6736(12)60437-1
  13. Naujok Ortwin, Lenzen Sigurd, A Critical Re-Evaluation of CD24-Positivity of Human Embryonic Stem Cells Differentiated into Pancreatic Progenitors, 10.1007/s12015-012-9362-y
  14. Kelly Olivia G, Chan Man Yin, Martinson Laura A, Kadoya Kuniko, Ostertag Traci M, Ross Kelly G, Richardson Mike, Carpenter Melissa K, D'Amour Kevin A, Kroon Evert, Moorman Mark, Baetge Emmanuel E, Bang Anne G, Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells, 10.1038/nbt.1931
  15. Wagner Wolfgang, Implications of long-term culture for mesenchymal stem cells: genetic defects or epigenetic regulation?, 10.1186/scrt145
  16. Prockop D. J., Olson S. D., Clinical trials with adult stem/progenitor cells for tissue repair: let's not overlook some essential precautions, 10.1182/blood-2006-03-013433
  17. Desgraz R, Bonal C, Herrera PL. beta-cell regeneration: the pancreatic intrinsic faculty. TEM. 2011;22:34–43.
  18. Meier J. J., Butler A. E., Saisho Y., Monchamp T., Galasso R., Bhushan A., Rizza R. A., Butler P. C.,  -Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of  -Cell Mass in Humans, 10.2337/db07-1369
  19. Gregg Brigid E., Moore Patrick C., Demozay Damien, Hall Ben A., Li Mei, Husain Aliya, Wright Amy J., Atkinson Mark A., Rhodes Christopher J., Formation of a Human β-Cell Population within Pancreatic Islets Is Set Early in Life, 10.1210/jc.2012-1206
  20. Perl S., Kushner J. A., Buchholz B. A., Meeker A. K., Stein G. M., Hsieh M., Kirby M., Pechhold S., Liu E. H., Harlan D. M., Tisdale J. F., Significant Human β-Cell Turnover Is Limited to the First Three Decades of Life as Determined byin VivoThymidine Analog Incorporation and Radiocarbon Dating, 10.1210/jc.2010-0932
  21. Reers C., Erbel S., Esposito I., Schmied B., Buchler M. W, Nawroth P. P, Ritzel R. A, Impaired islet turnover in human donor pancreata with aging, 10.1530/eje-08-0596
  22. Caballero Francisco, Siniakowicz Karolina, Hollister-Lock Jennifer, Duran Luisa, Katsuta Hitoshi, Yamada Takatsugu, Lei Ji, Deng Shaoping, Westermark Gunilla T., Markmann James, Bonner-Weir Susan, Weir Gordon C., Birth and Death of Human β-Cells in Pancreases from Cadaver Donors, Autopsies, Surgical Specimens, and Islets Transplanted into Mice, 10.3727/096368912x659916
  23. Rahier J., Guiot Y., Goebbels R. M., Sempoux C., Henquin J. C., Pancreatic β-cell mass in European subjects with type 2 diabetes, 10.1111/j.1463-1326.2008.00969.x
  24. Hanley Stephen C., Austin Emily, Assouline-Thomas Béatrice, Kapeluto Jordanna, Blaichman Jason, Moosavi Mandana, Petropavlovskaia Maria, Rosenberg Lawrence, β-Cell Mass Dynamics and Islet Cell Plasticity in Human Type 2 Diabetes, 10.1210/en.2009-1277
  25. Rieck S, Kaestner KH. Expansion of beta-cell mass in response to pregnancy. TEM. 2010;21:151–8.
  26. Butler A. E., Cao-Minh L., Galasso R., Rizza R. A., Corradin A., Cobelli C., Butler P. C., Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy, 10.1007/s00125-010-1809-6
  27. Kim Hail, Toyofuku Yukiko, Lynn Francis C, Chak Eric, Uchida Toyoyoshi, Mizukami Hiroki, Fujitani Yoshio, Kawamori Ryuzo, Miyatsuka Takeshi, Kosaka Yasuhiro, Yang Katherine, Honig Gerard, van der Hart Marieke, Kishimoto Nina, Wang Juehu, Yagihashi Soroku, Tecott Laurence H, Watada Hirotaka, German Michael S, Serotonin regulates pancreatic beta cell mass during pregnancy, 10.1038/nm.2173
  28. Zhang H., Zhang J., Pope C. F., Crawford L. A., Vasavada R. C., Jagasia S. M., Gannon M., Gestational Diabetes Mellitus Resulting From Impaired  -Cell Compensation in the Absence of FoxM1, a Novel Downstream Effector of Placental Lactogen, 10.2337/db09-0050
  29. Davis Dawn Belt, Lavine Jeremy A., Suhonen Joshua I., Krautkramer Kimberly A., Rabaglia Mary E., Sperger Jamie M., Fernandez Luis A., Yandell Brian S., Keller Mark P., Wang I-Ming, Schadt Eric E., Attie Alan D., FoxM1 Is Up-Regulated by Obesity and Stimulates β-Cell Proliferation, 10.1210/me.2010-0082
  30. Karnik S. K., Chen H., McLean G. W., Heit J. J., Gu X., Zhang A. Y., Fontaine M., Yen M. H., Kim S. K., Menin Controls Growth of Pancreatic  -Cells in Pregnant Mice and Promotes Gestational Diabetes Mellitus, 10.1126/science.1146812
  31. Jacovetti Cécile, Abderrahmani Amar, Parnaud Géraldine, Jonas Jean-Christophe, Peyot Marie-Line, Cornu Marion, Laybutt Ross, Meugnier Emmanuelle, Rome Sophie, Thorens Bernard, Prentki Marc, Bosco Domenico, Regazzi Romano, MicroRNAs contribute to compensatory β cell expansion during pregnancy and obesity, 10.1172/jci64151
  32. Cozar-Castellano Irene, Fiaschi-Taesch Nathalie, Bigatel Todd A., Takane Karen K., Garcia-Ocaña Adolfo, Vasavada Rupangi, Stewart Andrew F., Molecular Control of Cell Cycle Progression in the Pancreatic β-Cell, 10.1210/er.2006-0004
  33. Kulkarni R. N., Mizrachi E.-B., Ocana A. G., Stewart A. F., Human  -Cell Proliferation and Intracellular Signaling: Driving in the Dark Without a Road Map, 10.2337/db12-0018
  34. Cozar-Castellano I., Takane K. K., Bottino R., Balamurugan A.N., Stewart A. F., Induction of  -Cell Proliferation and Retinoblastoma Protein Phosphorylation in Rat and Human Islets Using Adenovirus-Mediated Transfer of Cyclin-Dependent Kinase-4 and Cyclin D1, 10.2337/diabetes.53.1.149
  35. Fiaschi-Taesch N., Bigatel T. A., Sicari B., Takane K. K., Salim F., Velazquez-Garcia S., Harb G., Selk K., Cozar-Castellano I., Stewart A. F., Survey of the Human Pancreatic  -Cell G1/S Proteome Reveals a Potential Therapeutic Role for Cdk-6 and Cyclin D1 in Enhancing Human  -Cell Replication and Function In Vivo, 10.2337/db08-0631
  36. Firestone Ari J., Chen James K., Controlling Destiny through Chemistry: Small-Molecule Regulators of Cell Fate, 10.1021/cb900249y
  37. Vetere Amedeo, Wagner Bridget K., Chemical Methods to Induce Beta-Cell Proliferation, 10.1155/2012/925143
  38. Annes J. P., Ryu J. H., Lam K., Carolan P. J., Utz K., Hollister-Lock J., Arvanites A. C., Rubin L. L., Weir G., Melton D. A., Adenosine kinase inhibition selectively promotes rodent and porcine islet  -cell replication, 10.1073/pnas.1201149109
  39. Andersson Olov, Adams Bruce A., Yoo Daniel, Ellis Gregory C., Gut Philipp, Anderson Ryan M., German Michael S., Stainier Didier Y.R., Adenosine Signaling Promotes Regeneration of Pancreatic β Cells In Vivo, 10.1016/j.cmet.2012.04.018
  40. Rulifson I. C., Karnik S. K., Heiser P. W., ten Berge D., Chen H., Gu X., Taketo M. M., Nusse R., Hebrok M., Kim S. K., Wnt signaling regulates pancreatic beta cell proliferation, 10.1073/pnas.0701509104
  41. Elghazi L., Rachdi L., Weiss A. J., Cras-Méneur C., Bernal-Mizrachi E., Regulation of ?-cell mass and function by the Akt/protein kinase B signalling pathway, 10.1111/j.1463-1326.2007.00783.x
  42. Welters HJ, Kulkarni RN. Wnt signaling: relevance to beta-cell biology and diabetes. TEM. 2008;19:349–55.
  43. Stukenbrock Hendrik, Mussmann Rainer, Geese Marcus, Ferandin Yoan, Lozach Olivier, Lemcke Thomas, Kegel Simone, Lomow Alexander, Burk Ulrike, Dohrmann Cord, Meijer Laurent, Austen Matthias, Kunick Conrad, 9-Cyano-1-azapaullone (Cazpaullone), a Glycogen Synthase Kinase-3 (GSK-3) Inhibitor Activating Pancreatic β Cell Protection and Replication, 10.1021/jm701582f
  44. Kassem Sameer, Bhandari Sonal, Rodríguez-Bada Pablo, Motaghedi Roja, Heyman Maayan, García-Gimeno M. Adelaida, Cobo-Vuilleumier Nadia, Sanz Pascual, Maclaren Noel K., Rahier Jacques, Glaser Benjamin, Cuesta-Muñoz Antonio Luis, Large Islets, Beta-Cell Proliferation, and a Glucokinase Mutation, 10.1056/nejmc0909845
  45. Terauchi Y., Takamoto I., Kubota N., Matsui J., Suzuki R., Komeda K., Hara A., Toyoda Y., Miwa I., Aizawa S., Tsutsumi S., Tsubamoto Y., Hashimoto S., Eto K., Nakamura A., Noda M., Tobe K., Aburatani H., Nagai R., Kadowaki T., Glucokinase and IRS-2 are required for compensatory   cell hyperplasia in response to high-fat diet-induced insulin resistance, 10.1172/jci17645
  46. Nakamura Akinobu, Terauchi Yasuo, Ohyama Sumika, Kubota Junko, Shimazaki Hiroko, Nambu Tadahiro, Takamoto Iseki, Kubota Naoto, Eiki Junichi, Yoshioka Narihito, Kadowaki Takashi, Koike Takao, Impact of Small-Molecule Glucokinase Activator on Glucose Metabolism and β-Cell Mass, 10.1210/en.2008-1183
  47. Nakamura A., Togashi Y., Orime K., Sato K., Shirakawa J., Ohsugi M., Kubota N., Kadowaki T., Terauchi Y., Control of beta cell function and proliferation in mice stimulated by small-molecule glucokinase activator under various conditions, 10.1007/s00125-012-2521-5
  48. Matschinsky Franz M., Zelent Bogumil, Doliba Nicolai M., Kaestner Klaus H., Vanderkooi Jane M., Grimsby Joseph, Berthel Steven J., Sarabu Ramakanth, Research and Development of Glucokinase Activators for Diabetes Therapy: Theoretical and Practical Aspects, Diabetes - Perspectives in Drug Therapy (2011) ISBN:9783642172137 p.357-401, 10.1007/978-3-642-17214-4_15
  49. Zhang X, et al. Dose selection using a semi-mechanistic integrated glucose-insulin-glucagon model: designing phase 2 trials for a novel oral glucokinase activator. J Pharmacokin Pharmacodynam. 2012.
  50. Garber A. J., Incretin Effects on  -Cell Function, Replication, and Mass: The human perspective, 10.2337/dc11-s230
  51. Xu G., Stoffers D. A., Habener J. F., Bonner-Weir S., Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats, 10.2337/diabetes.48.12.2270
  52. Sturis Jeppe, Gotfredsen Carsten F, Rømer John, Rolin Bidda, Ribel Ulla, Brand Christian L, Wilken Michael, Wassermann Karsten, Deacon Carolyn F, Carr Richard D, Knudsen Lotte Bjerre, GLP-1 derivative liraglutide in rats withβ-cell deficiencies: influence of metabolic state onβ-cell mass dynamics, 10.1038/sj.bjp.0705397
  53. Tian Lei, Gao Jie, Weng Guangbin, Yi Huimin, Tian Bole, O’Brien Timothy D., Guo Zhiguang, Comparison of exendin-4 on beta-cell replication in mouse and human islet grafts : Exendin-4 on beta-cell replication in islet grafts, 10.1111/j.1432-2277.2011.01275.x
  54. Talchai Chutima, Xuan Shouhong, Lin Hua V., Sussel Lori, Accili Domenico, Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure, 10.1016/j.cell.2012.07.029
  55. Jonas Jean-Christophe, Sharma Arun, Hasenkamp Wendy, Ilkova Hasan, Patanè Giovanni, Laybutt Ross, Bonner-Weir Susan, Weir Gordon C., Chronic Hyperglycemia Triggers Loss of Pancreatic β Cell Differentiation in an Animal Model of Diabetes, 10.1074/jbc.274.20.14112
  56. Laybutt D. Ross, Glandt Mariela, Xu Gang, Ahn Yu Bai, Trivedi Nitin, Bonner-Weir Susan, Weir Gordon C., Critical Reduction in β-Cell Mass Results in Two Distinct Outcomes over Time : ADAPTATION WITH IMPAIRED GLUCOSE TOLERANCE OR DECOMPENSATED DIABETES, 10.1074/jbc.m210581200
  57. Russ H. A., Bar Y., Ravassard P., Efrat S., In Vitro Proliferation of Cells Derived From Adult Human  -Cells Revealed By Cell-Lineage Tracing, 10.2337/db07-1283
  58. Russ Holger A., Ravassard Philippe, Kerr-Conte Julie, Pattou Francois, Efrat Shimon, Epithelial-Mesenchymal Transition in Cells Expanded In Vitro from Lineage-Traced Adult Human Pancreatic Beta Cells, 10.1371/journal.pone.0006417
  59. Russ Holger A., Sintov Elad, Anker-Kitai Leeat, Friedman Orr, Lenz Ayelet, Toren Ginat, Farhy Chen, Pasmanik-Chor Metsada, Oron-Karni Varda, Ravassard Philippe, Efrat Shimon, Insulin-Producing Cells Generated from Dedifferentiated Human Pancreatic Beta Cells Expanded In Vitro, 10.1371/journal.pone.0025566
  60. Bar Yael, Russ Holger A., Sintov Elad, Anker-Kitai Leeat, Knoller Sarah, Efrat Shimon, Redifferentiation of Expanded Human Pancreatic β-Cell-derived Cells by Inhibition of the NOTCH Pathway, 10.1074/jbc.m111.319152
  61. Bonner-Weir S., Li W.-C., Ouziel-Yahalom L., Guo L., Weir G. C., Sharma A.,  -Cell Growth and Regeneration: Replication Is Only Part of the Story, 10.2337/db10-0084
  62. Xu Xiaobo, D'Hoker Joke, Stangé Geert, Bonné Stefan, De Leu Nico, Xiao Xiangwei, Van De Casteele Mark, Mellitzer Georg, Ling Zhidong, Pipeleers Danny, Bouwens Luc, Scharfmann Raphael, Gradwohl Gerard, Heimberg Harry, β Cells Can Be Generated from Endogenous Progenitors in Injured Adult Mouse Pancreas, 10.1016/j.cell.2007.12.015
  63. Kopp J. L., Dubois C. L., Schaffer A. E., Hao E., Shih H. P., Seymour P. A., Ma J., Sander M., Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas, 10.1242/dev.056499
  64. Furuyama Kenichiro, Kawaguchi Yoshiya, Akiyama Haruhiko, Horiguchi Masashi, Kodama Sota, Kuhara Takeshi, Hosokawa Shinichi, Elbahrawy Ashraf, Soeda Tsunemitsu, Koizumi Masayuki, Masui Toshihiko, Kawaguchi Michiya, Takaori Kyoichi, Doi Ryuichiro, Nishi Eiichiro, Kakinoki Ryosuke, Deng Jian Min, Behringer Richard R, Nakamura Takashi, Uemoto Shinji, Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine, 10.1038/ng.722
  65. Solar Myriam, Cardalda Carina, Houbracken Isabelle, Martín Mercè, Maestro Miguel Angel, De Medts Nele, Xu Xiaobo, Grau Vanessa, Heimberg Harry, Bouwens Luc, Ferrer Jorge, Pancreatic Exocrine Duct Cells Give Rise to Insulin-Producing β Cells during Embryogenesis but Not after Birth, 10.1016/j.devcel.2009.11.003
  66. Inada A., Nienaber C., Katsuta H., Fujitani Y., Levine J., Morita R., Sharma A., Bonner-Weir S., Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth, 10.1073/pnas.0805803105
  67. Criscimanna Angela, Speicher Julie A., Houshmand Golbahar, Shiota Chiyo, Prasadan Krishna, Ji Baoan, Logsdon Craig D., Gittes George K., Esni Farzad, Duct Cells Contribute to Regeneration of Endocrine and Acinar Cells Following Pancreatic Damage in Adult Mice, 10.1053/j.gastro.2011.07.003
  68. Nakamura Korefumi, Minami Kohtaro, Tamura Kanako, Iemoto Keisuke, Miki Takashi, Seino Susumu, Pancreatic β-cells are generated by neogenesis from non-β-cells after birth, 10.2220/biomedres.32.167
  69. Pan F. C., Bankaitis E. D., Boyer D., Xu X., Van de Casteele M., Magnuson M. A., Heimberg H., Wright C. V. E., Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration, 10.1242/dev.090159
  70. Ouziel-Yahalom L, et al. Ductal heterogeneity suggests a subpopulation serves as postantal pancreatic progenitors. Diabetes. 2010;59(Suppl 1):A25.
  71. Reinert Rachel B., Kantz Jeannelle, Misfeldt Amanda Ackermann, Poffenberger Greg, Gannon Maureen, Brissova Marcela, Powers Alvin C., Tamoxifen-Induced Cre-loxP Recombination Is Prolonged in Pancreatic Islets of Adult Mice, 10.1371/journal.pone.0033529
  72. Meier J. J., Butler A. E., Galasso R., Butler P. C., Hyperinsulinemic Hypoglycemia After Gastric Bypass Surgery Is Not Accompanied by Islet Hyperplasia or Increased  -Cell Turnover, 10.2337/dc06-0392
  73. Yatoh S., Dodge R., Akashi T., Omer A., Sharma A., Weir G. C., Bonner-Weir S., Differentiation of Affinity-Purified Human Pancreatic Duct Cells to  -Cells, 10.2337/db06-1670
  74. Baertschiger Reto M., Bosco Domenico, Morel Philippe, Serre-Beinier Veronique, Berney Thierry, Buhler Leo H., Gonelle-Gispert Carmen, Mesenchymal Stem Cells Derived From Human Exocrine Pancreas Express Transcription Factors Implicated in Beta-Cell Development : , 10.1097/mpa.0b013e31815fcb1e
  75. Seeberger Karen L, Dufour Jannette M, Shapiro Andrew M James, Lakey Jonathan R T, Rajotte Ray V, Korbutt Gregory S, Expansion of mesenchymal stem cells from human pancreatic ductal epithelium, 10.1038/labinvest.3700377
  76. Lysy P et al. Partial transition towards a mesenchymal phenotype allows human panreatic duct cells to proliferate while showing a beta-cell differentiation potential in vitro. Horm Res Pediatrics. 2011;76(Suppl2):34.
  77. Collombat Patrick, Xu Xiaobo, Ravassard Philippe, Sosa-Pineda Beatriz, Dussaud Sébastien, Billestrup Nils, Madsen Ole D., Serup Palle, Heimberg Harry, Mansouri Ahmed, The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into α and Subsequently β Cells, 10.1016/j.cell.2009.05.035
  78. Baeyens L., De Breuck S., Lardon J., Mfopou J. K., Rooman I., Bouwens L., In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells, 10.1007/s00125-004-1606-1
  79. Bertelli E, Bendayan M. Intermediate endocrine-acinar pancreatic cells in duct ligation conditions. Am J Physiol. 1997;273(5 Pt 1):C1641–9.
  80. Hesselson Daniel, Anderson Ryan M., Stainier Didier Y.R., Suppression of Ptf1a Activity Induces Acinar-to-Endocrine Conversion, 10.1016/j.cub.2011.03.041
  81. Desai Biva M., Oliver-Krasinski Jennifer, De Leon Diva D., Farzad Cyrus, Hong Nankang, Leach Steven D., Stoffers Doris A., Preexisting pancreatic acinar cells contribute to acinar cell, but not islet β cell, regeneration, 10.1172/jci29988
  82. Houbracken I, et al. Lineage tracing evidence for transdifferentiation of acinar to duct cells and plasticity of human pancreas. Gastroenterology. 2011;141:731–41, 741 e1–4.
  83. Zhou Qiao, Brown Juliana, Kanarek Andrew, Rajagopal Jayaraj, Melton Douglas A., In vivo reprogramming of adult pancreatic exocrine cells to β-cells, 10.1038/nature07314
  84. Wang Alfred Y., Peng Peter D., Ehrhardt Anja, Storm Theresa A., Kay Mark A., Comparison of Adenoviral and Adeno-Associated Viral Vectors for Pancreatic Gene DeliveryIn Vivo, 10.1089/104303404322959551
  85. Kim Dohoon, Kim Chun-Hyung, Moon Jung-Il, Chung Young-Gie, Chang Mi-Yoon, Han Baek-Soo, Ko Sanghyeok, Yang Eungi, Cha Kwang Yul, Lanza Robert, Kim Kwang-Soo, Generation of Human Induced Pluripotent Stem Cells by Direct Delivery of Reprogramming Proteins, 10.1016/j.stem.2009.05.005
  86. Warren Luigi, Manos Philip D., Ahfeldt Tim, Loh Yuin-Han, Li Hu, Lau Frank, Ebina Wataru, Mandal Pankaj K., Smith Zachary D., Meissner Alexander, Daley George Q., Brack Andrew S., Collins James J., Cowan Chad, Schlaeger Thorsten M., Rossi Derrick J., Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA, 10.1016/j.stem.2010.08.012
  87. Smith Stuart B., Qu Hui-Qi, Taleb Nadine, Kishimoto Nina Y., Scheel David W., Lu Yang, Patch Ann-Marie, Grabs Rosemary, Wang Juehu, Lynn Francis C., Miyatsuka Takeshi, Mitchell John, Seerke Rina, Désir Julie, Eijnden Serge Vanden, Abramowicz Marc, Kacet Nadine, Weill Jacques, Renard Marie-Ève, Gentile Mattia, Hansen Inger, Dewar Ken, Hattersley Andrew T., Wang Rennian, Wilson Maria E., Johnson Jeffrey D., Polychronakos Constantin, German Michael S., Rfx6 directs islet formation and insulin production in mice and humans, 10.1038/nature08748
  88. Zhou Qiao, Law Anica C., Rajagopal Jayaraj, Anderson William J., Gray Paul A., Melton Douglas A., A Multipotent Progenitor Domain Guides Pancreatic Organogenesis, 10.1016/j.devcel.2007.06.001
  89. Gifford Casey A, Meissner Alexander, Epigenetic obstacles encountered by transcription factors: reprogramming against all odds, 10.1016/j.gde.2012.08.002
  90. Collombat Patrick, Hecksher-Sørensen Jacob, Krull Jens, Berger Joachim, Riedel Dietmar, Herrera Pedro L., Serup Palle, Mansouri Ahmed, Embryonic endocrine pancreas and mature β cells acquire α and PP cell phenotypes upon Arx misexpression, 10.1172/jci29115
  91. Thorel Fabrizio, Népote Virginie, Avril Isabelle, Kohno Kenji, Desgraz Renaud, Chera Simona, Herrera Pedro L., Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss, 10.1038/nature08894
  92. Yang Y.-P., Thorel F., Boyer D. F., Herrera P. L., Wright C. V. E., Context-specific  -to- -cell reprogramming by forced Pdx1 expression, 10.1101/gad.16875711
  93. Gianani Roberto, Beta cell regeneration in human pancreas, 10.1007/s00281-010-0235-7
  94. Rezania A., Riedel M. J., Wideman R. D., Karanu F., Ao Z., Warnock G. L., Kieffer T. J., Production of Functional Glucagon-Secreting  -Cells From Human Embryonic Stem Cells, 10.2337/db10-0573
  95. Fomina-Yadlin D., Kubicek S., Walpita D., Dancik V., Hecksher-Sorensen J., Bittker J. A., Sharifnia T., Shamji A., Clemons P. A., Wagner B. K., Schreiber S. L., Small-molecule inducers of insulin expression in pancreatic  -cells, 10.1073/pnas.1010018107
  96. Saisho Yoshifumi, Manesso Erica, Butler Alexandra E., Galasso Ryan, Kavanagh Kylie, Flynn Mickey, Zhang Li, Clark Paige, Gurlo Tatyana, Toffolo Gianna M., Cobelli Claudio, Wagner Janice D., Butler Peter C., Ongoing β-Cell Turnover in Adult Nonhuman Primates Is Not Adaptively Increased in Streptozotocin-Induced Diabetes, 10.2337/db09-1368
  97. Jones RJ et al. Assessment of aldehyde dehydrogenase in viable cells. Blood. 1995;85:2742–6.
  98. Gasparetto Maura, Sekulovic Sanja, Brocker Chad, Tang Patrick, Zakaryan Anush, Xiang Ping, Kuchenbauer Florian, Wen Maggie, Kasaian Katayoon, Witty Marie France, Rosten Patty, Chen Ying, Imren Suzan, Duester Gregg, Thompson David C., Humphries Richard Keith, Vasiliou Vasilis, Smith Clay, Aldehyde dehydrogenases are regulators of hematopoietic stem cell numbers and B-cell development, 10.1016/j.exphem.2011.12.006
  99. Rovira M., Scott S.-G., Liss A. S., Jensen J., Thayer S. P., Leach S. D., Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas, 10.1073/pnas.0912589107
  100. Hayashi Keiko Y., Tamaki Hideaki, Handa Kimiya, Takahashi Tsuyoshi, Kakita Akira, Yamashina Shohei, Differentiation and proliferation of endocrine cells in the regenerating rat pancreas after 90% pancreatectomy, 10.1679/aohc.66.163
  101. Ioannou Marilia, Serafimidis Ioannis, Arnes Luis, Sussel Lori, Singh Surendra, Vasiliou Vasilis, Gavalas Anthony, ALDH1B1 is a potential stem/progenitor marker for multiple pancreas progenitor pools, 10.1016/j.ydbio.2012.10.030
  102. Seaberg Raewyn M, Smukler Simon R, Kieffer Timothy J, Enikolopov Grigori, Asghar Zeenat, Wheeler Michael B, Korbutt Gregory, van der Kooy Derek, Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages, 10.1038/nbt1004
  103. Smukler Simon R., Arntfield Margot E., Razavi Rozita, Bikopoulos George, Karpowicz Phillip, Seaberg Raewyn, Dai Feihan, Lee Simon, Ahrens Rosemary, Fraser Paul E., Wheeler Michael B., van der Kooy Derek, The Adult Mouse and Human Pancreas Contain Rare Multipotent Stem Cells that Express Insulin, 10.1016/j.stem.2011.01.015
  104. Hald J., Galbo T., Rescan C., Radzikowski L., Sprinkel A. E., Heimberg H., Ahnfelt-Rønne J., Jensen J., Scharfmann R., Gradwohl G., Kaestner K. H., Stoeckert C., Jensen J. N., Madsen O. D., Pancreatic islet and progenitor cell surface markers with cell sorting potential, 10.1007/s00125-011-2295-1