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Effects of marginal iron overload on iron homeostasis and immune function in alveolar macrophages isolated from pregnant and normal rats.

Bibliographic reference Ward, Roberta J. ; Wilmet, Stephanie ; Legssyer, Rachida ; Leroy, Daniel ; Toussaint, Louise ; et. al. Effects of marginal iron overload on iron homeostasis and immune function in alveolar macrophages isolated from pregnant and normal rats.. In: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, Vol. 22, no. 2, p. 211-23 (2009)
Permanent URL http://hdl.handle.net/2078.1/14166
  1. Beauchamp C, Fridovich I (1971) Superoxide dismutase improved assays and an assay applicable to acrylamide gels. Anal Biochem 44:276–287. doi: 10.1016/0003-2697(71)90370-8
  2. Bowie LA, O’Neill LA (2000) Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries. Biochem Pharmacol 59:13–23. doi: 10.1016/S0006-2952(99)00296-8
  3. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye-binding. Anal Biochem 72:248–254. doi: 10.1016/0003-2697(76)90527-3
  4. Carr RB (1990) The fetal maternal placental unit. In: Becker KL (ed) Principles and practice of endocrinology and metabolism. J.B. Lippincott, pp 788
  5. Casanueva E, Viteri FE (2003) Iron and oxidative stress in pregnancy. Am Soc Nutr Sci 133:1700S–1708S
  6. Crichton RR, Wilmet S, Legssyer R, Ward RJ (2002) Molecular and cellular mechanisms of iron homeostasis and toxicity in mammalian cells. J Inorg Biochem 91:9–18. doi: 10.1016/S0162-0134(02)00461-0
  7. Crocker IP, Lawson PN, Baker PN, Fletcher J (2001) The anti-inflammatory effects of circulating fatty acids in obstructive jaundice: similarities with pregnancy-induced immunosuppression. QJM 94:475–484. doi: 10.1093/qjmed/94.9.475
  8. Dealtry GB, O’Farrell MK, Fernandez N (2000) The Th2 cytokine environment of the placenta. Int Arch Allergy Immunol 123(2):107–119. doi: 10.1159/000024441
  9. Dechend R, Viedt C, Muller DN, Ugele B, Brandes RP, Wallukat G et al (2003) AT1 receptor agonistic antibodies from preeclamptic patients stimulate NADPH oxidase. Circulation 107:1632–1639. doi: 10.1161/01.CIR.0000058200.90059.B1
  10. De Domenico I, Ward DM, Langelier C, Vaughn MB, Nemeth E, Sundquist WI et al (2007) The molecular mechanism of hepcidin-mediated ferroportin down-regulation. Mol Biol Cell 18:2569–2578. doi: 10.1091/mbc.E07-01-0060
  11. Dlaska M, Weiss G (1999) Central control of transcription factor NF-IL6 for cytokine and iron mediated regulation of murine inducible nitric oxide synthase expression. J Immunol 162:6171–6177
  12. Dupic F, Fruchon S, Bensaid M, Loreal O, Brissot P, Borot N et al (2002) Duodenal mRNA expression of iron related genes in response to iron loading and iron deficiency in four strains of mice. Gut 51:648–653. doi: 10.1136/gut.51.5.648
  13. Ibouno LE, Shu EN, Igbokwe GE (1996) An improved technique for the assay of red blood cell superoxide dismutase (SOD) activity. Clin Chim Acta 247:1–6. doi: 10.1016/0009-8981(95)06193-2
  14. Kim S, Ponka P (2000) Effects of interferon-γ and lipopolysaccharide on macrophage iron metabolism are mediated by nitric oxide-induced degradation of iron regulatory protein 2. J Biol Chem 275:6220–6226. doi: 10.1074/jbc.275.9.6220
  15. Kustermans G, El Benna J, Piette J, Legrand-Poels S (2005) Perturbation of actin dynamics induces NF-kappaB activation in myelomonocytic cells through an NADPH oxidase-dependent pathway. Biochem J 387:531–540. doi: 10.1042/BJ20041318
  16. Lachili B, Hininger I, Faure H, Arnaud J, Richard MJ, Favier A et al (2001) Increased lipid peroxidation in pregnant women after iron and vitamin C supplementation. Biol Trace Elem Res 83:103–110. doi: 10.1385/BTER:83:2:103
  17. Legssyer R, Ward RJ, Crichton RR (1999) Effect of chronic chloroquine administration on iron loading in the liver and reticuloendothelial system and on oxidative responses by the macrophage. Biochem Pharmacol 57:907–911. doi: 10.1016/S0006-2952(98)00368-2
  18. Legssyer R, Josse C, Piette J, Ward RJ, Crichton RR (2003) Changes in function of iron-loaded alveolar macrophages after in vivo administration of desferrioxamine and/or chloroquine. J Inorg Biochem 94:36–42. doi: 10.1016/S0162-0134(02)00633-5
  19. Lu DY, Liou HC, Tang CH, Fu WM (2006) Hypoxia-induced iNOS expression in microglia is regulated by the PI3-kinase/Akt/mTOR signaling pathway and activation of hypoxia inducible factor-1alpha. Biochem Pharmacol 72:992–1000. doi: 10.1016/j.bcp. 2006.06.038
  20. Mellor A, Munn DH (2000) Immunology at the maternal-fetal interface: lessons for T cell tolerance and suppression. Annu Rev Immunol 18:367–391. doi: 10.1146/annurev.immunol.18.1.367
  21. Millard K, Frazer D, Wilkins SJ, Anderson GR (2004) Changes in the expression of intestinal iron transport and hepatic regulatory molecules explain the enhanced iron absorption associated with pregnancy in the rat. Gut 53:655–660. doi: 10.1136/gut.2003.031153
  22. Mukhopadhyay A, Bhatla N, Kriplani A, Agarway N, Saxena R (2004) Erythrocyte indices in pregnancy: effect of intermittent iron supplementation. Natl Med J India 17:135–137
  23. Myatt L, Cui X (2004) Oxidative stress in the placenta. Histochem Cell Biol 122:369–382. doi: 10.1007/s00418-004-0677-x
  24. Nemeth E, Ganz T (2006) Regulation of iron metabolism by hepcidin. Annu Rev Nutr 26:323–342. doi: 10.1146/annurev.nutr.26.061505.111303
  25. Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM et al (2004) Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306:2090–2093. doi: 10.1126/science.1104742
  26. Oppenheimer SJ (2001) Iron and its relation to immunity and infectious disease. J Nutr 131:616S–635S
  27. Park CH, Valore EV, Waring AJ, Ganz T (2001) Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 276:7806–7810. doi: 10.1074/jbc.M008922200
  28. Qanungo S, Mukherjea M (2000) Ontogenic profile of some antioxidants and lipid peroxidation in human placental and fetal tissues. Mol Cell Biochem 215:11–19. doi: 10.1023/A:1026511420505
  29. Raghupathy R (1997) Th1-type immunity is incompatible with successful pregnancy. Immunol Today 18(10):478–482. doi: 10.1016/S0167-5699(97)01127-4
  30. Rioux FM, LeBlanc CP (2007) Iron supplementation during pregnancy: what are the risks and benefits of current practices? Appl Physiol Nutr Metab 32:282–288. doi: 10.1139/H07-012
  31. Stolzfus R, Dreyfuss M (1988) Guidelines for the use of iron supplements to prevent and treat iron deficiency anaemia. International nutritional anaemia consultative group. ILSI Press, Washington
  32. Thomas C, Oates PS (2002) IEC-6 cells are an appropriate model of intestinal iron absorption in rats. J Nutr 132:680–687
  33. Uotila J, Tuimala R, Aarnio T, Pyykko K, Ahotupa M (1991) Lipid peroxidation products, selenium-dependent glutathione peroxidase and vitamin E in normal pregnancy Eur J Obstet. Reprod Biol 42:95–100
  34. Ward RJ, Kuhn L, Kaldy P, Florence A, Peters TJ, Crichton RR (1994) Control of cellular iron homeostasis by Iron Responsive Element (IRE) in vivo. Eur J Biochem 220:927–931. doi: 10.1111/j.1432-1033.1994.tb18696.x
  35. Ward RJ, Zhang Y, Crichton RR, Biret B, Piette J, De Witte P (1996) Expression of NFKappaB in rat brain after administration of ethanol in vivo. FEBS Lett 389:119–122. doi: 10.1016/0014-5793(96)00545-5
  36. Ward RJ, Wilmet S, Legssyer R, Crichton RR (2004) Iron supplementation during pregnancy-a necessary or toxic supplement. Bioinorg Chem Appl 1:169–176. doi: 10.1155/S156536330300013X
  37. Wisdom Stephen J., Wilson Rhoda, McKillop James H., Walker James J., Antioxidant systems in normal pregnancy and in pregnancy-induced hypertension, 10.1016/0002-9378(91)90018-m
  38. WHO (2001) WHO/NHD/01.3. Geneva
  39. Zhang Y, Crichton RR, Boelaert JR, Jorens PG, Herman AG, Ward RJ et al (1998) Decreased release of nitric oxide by alveolar macrophages after in vivo loading with iron or ethanol. Biochem Pharmacol 55:21–25. doi: 10.1016/S0006-2952(97)00382-1
  40. Batey RG, Gallagher ND (1977) Role of the placenta in intestinal absorption of iron in pregnant rats. Gastroenterol 72:255–257