Signal transduction molecule patterns indicating potential glioblastoma therapy approaches.

Cruceru, Maria Linda Enciu, Ana-Maria Popa, Adrian Claudiu Albulescu, Radu Neagu, Monica Tanase, Cristiana Pistol Constantinescu, Stefan N. [UCL] et al.[show all]

The expression of an array of signaling molecules, along with the assessment of real-time cell proliferation, has been performed in U87 glioma cell line and in patients' glioblastoma established cell cultures in order to provide a better understanding of cellular and molecular events involved in glioblastoma pathogenesis. Experimental therapy was performed using a phosphatidylinositol-3'-kinase (PI3K) inhibitor.