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In vitro investigations of smart drug delivery systems based on redox-sensitive cross-linked micelles.

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Cajot, Sébastien Schol, Daureen Danhier, Fabienne Préat, Véronique Gillet De Pauw, Marie-Claire Jérôme, Christine

Redox-sensitive micelles are designed by using block copolymers of different architectures composed of a hydrophilic block of poly(ethylene oxide), and hydrophobic blocks of poly(ϵ-caprolactone) and poly(α-azide-ϵ-caprolactone). Stability of these micelles is insured in diluted media by cross-linking their core via the addition of a bifunctional cross-linker, while redox sensitivity is provided to these micelles by inserting a disulfide bridge in the cross-linker. The potential of these responsive micelles to be used as nanocarriers is studied in terms of cytotoxicity and cellular internalization. The release profiles are also investigated by varying the environment reductive strength.

Document type Article de périodique (Journal article)
Access type Accès restreint
Publication date 2013
Language Anglais
Journal information "Macromolecular Bioscience" - Vol. 13, no. 12, p. 1661-70 (2013)
Peer reviewed yes
Publisher Wiley (Weinheim)
issn 1616-5187
e-issn 1616-5195
Publication status Publié
Affiliation UCL - SSS/LDRI - Louvain Drug Research Institute
Keywords cross-linked micelles ; cytotoxicity ; disulfide bridges ; internalization ; smart drug delivery
Links
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Bibliographic reference Cajot, Sébastien ; Schol, Daureen ; Danhier, Fabienne ; Préat, Véronique ; Gillet De Pauw, Marie-Claire ; et. al. In vitro investigations of smart drug delivery systems based on redox-sensitive cross-linked micelles.. In: Macromolecular Bioscience, Vol. 13, no. 12, p. 1661-70 (2013)
Permanent URL http://hdl.handle.net/2078.1/140571