User menu

Accumulation of secreted antibodies in plant cell cultures varies according to the isotype, host species and culture conditions.

Bibliographic reference Magy, Bertrand ; Tollet, Jérémie ; Laterre, Raphaëlle ; Boutry, Marc ; Navarre, Catherine. Accumulation of secreted antibodies in plant cell cultures varies according to the isotype, host species and culture conditions.. In: Plant Biotechnology Journal, Vol. 12, no. 4, p. 457-467 (2013)
Permanent URL
  1. Axelos, Plant Physiol. Biochem., 30, 123 (1992)
  2. BAICI A., KNOPFEL M., FEHR K., Cleavage of the Four Human IgG Subclasses with Cathepsin G, 10.1111/j.1365-3083.1982.tb00750.x
  3. Benchabane Meriem, Goulet Charles, Rivard Daniel, Faye Loïc, Gomord Véronique, Michaud Dominique, Preventing unintended proteolysis in plant protein biofactories, 10.1111/j.1467-7652.2008.00344.x
  4. Berasain Patricia, Carmona Carlos, Frangione Blas, Cazzulo Juan José, Goñi Fernando, Specific cleavage sites on human IgG subclasses by cruzipain, the major cysteine proteinase from Trypanosoma cruzi, 10.1016/s0166-6851(03)00139-7
  5. Borderies Gisèle, Jamet Elisabeth, Lafitte Claude, Rossignol Michel, Jauneau Alain, Boudart Georges, Monsarrat Bernard, Esquerré-Tugayé Marie-Thérèse, Boudet Alain, Pont-Lezica Rafael, Proteomics of loosely bound cell wall proteins ofArabidopsis thaliana cell suspension cultures: A critical analysis, 10.1002/elps.200305608
  6. Bradford Marion M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, 10.1016/0003-2697(76)90527-3
  7. Brezski Randall J., Jordan Robert E., Cleavage of IgGs by proteases associated with invasive diseases : an evasion tactic against host immunity?, 10.4161/mabs.2.3.11780
  8. Calinski Anne, Classen Birgit, Zoglauer Kurt, Boehm Robert, IgG stability in fresh and conditioned medium of tobacco (Nicotiana tabacum) and larch (Larix decidua) embryogenic suspension cultures, 10.1007/s10529-009-9920-9
  9. Correia Ivan, Stability of IgG isotypes in serum, 10.4161/mabs.2.3.11788
  10. De Muynck Benoit, Navarre Catherine, Nizet Yannick, Stadlmann Johannes, Boutry Marc, Different subcellular localization and glycosylation for a functional antibody expressed in Nicotiana tabacum plants and suspension cells, 10.1007/s11248-008-9240-1
  11. De Muynck Benoit, Navarre Catherine, Boutry Marc, Production of antibodies in plants: status after twenty years : Antibodies in plants: twenty years later, 10.1111/j.1467-7652.2009.00494.x
  12. Doran Pauline M., Foreign protein degradation and instability in plants and plant tissue cultures, 10.1016/j.tibtech.2006.06.012
  13. Doran Pauline M., Loss of secreted antibody from transgenic plant tissue cultures due to surface adsorption, 10.1016/j.jbiotec.2005.08.029
  14. Doran, Curr. Med. Chem., 20, 1047 (2013)
  15. Fischer Rainer, Liao Yu-Cai, Drossard Jürgen, Affinity-purification of a TMV-specific recombinant full-size antibody from a transgenic tobacco suspension culture, 10.1016/s0022-1759(99)00058-7
  16. van der Fits Leslie, Deakin Edward A., Hoge J. Harry C., Memelink Johan, 10.1023/a:1006440221718
  17. Goderis Inge J.W.M., De Bolle Miguel F.C., François Isabelle E.J.A., Wouters Piet F.J., Broekaert Willem F., Cammue Bruno P.A., 10.1023/a:1016052416053
  18. Gomord Véronique, Fitchette Anne-Catherine, Menu-Bouaouiche Laurence, Saint-Jore-Dupas Claude, Plasson Carole, Michaud Dominique, Faye Loïc, Plant-specific glycosylation patterns in the context of therapeutic protein production : PMP-specific glycosylation patterns, 10.1111/j.1467-7652.2009.00497.x
  19. Hellwig Stephan, Drossard Jürgen, Twyman Richard M, Fischer Rainer, Plant cell cultures for the production of recombinant proteins, 10.1038/nbt1027
  20. Holland T., Sack M., Rademacher T., Schmale K., Altmann F., Stadlmann J., Fischer R., Hellwig S., Optimal nitrogen supply as a key to increased and sustained production of a monoclonal full-size antibody in BY-2 suspension culture, 10.1002/bit.22800
  21. Huang Ting-Kuo, McDonald Karen A., Molecular Farming Using Bioreactor-Based Plant Cell Suspension Cultures for Recombinant Protein Production, Molecular Farming in Plants: Recent Advances and Future Prospects (2012) ISBN:9789400722163 p.37-67, 10.1007/978-94-007-2217-0_3
  22. Kirchhoff Janina, Raven Nicole, Boes Alexander, Roberts Jean L., Russell Sean, Treffenfeldt Wiltrud, Fischer Rainer, Schinkel Helga, Schiermeyer Andreas, Schillberg Stefan, Monoclonal tobacco cell lines with enhanced recombinant protein yields can be generated from heterogeneous cell suspension cultures by flow sorting : Monoclonal tobacco cell lines, 10.1111/j.1467-7652.2012.00722.x
  23. Kwon Jun-Young, Lee Kyoung-Hoon, Cheon Su-Hwan, Ryu Hyun-Nam, Kim Sun Jin, Kim Dong-Il, Adsorptive loss of secreted recombinant proteins in transgenic rice cell suspension cultures, 10.1007/s00299-011-1184-x
  24. Loos Andreas, Steinkellner Herta, IgG-Fc glycoengineering in non-mammalian expression hosts, 10.1016/
  25. López J., Lencina F., Petruccelli S., Marconi P., Alvarez M. A., Influence of the KDEL signal, DMSO and mannitol on the production of the recombinant antibody 14D9 by long-term Nicotiana tabacum cell suspension culture, 10.1007/s11240-010-9780-y
  26. Huang Ting-Kuo, McDonald Karen A., Bioreactor engineering for recombinant protein production in plant cell suspension cultures, 10.1016/j.bej.2009.02.008
  27. Nagata Toshiyuki, Nemoto Yasuyuki, Hasezawa Seiichiro, Tobacco BY-2 Cell Line as the “HeLa” Cell in the Cell Biology of Higher Plants, International Review of Cytology (1992) ISBN:9780123645326 p.1-30, 10.1016/s0074-7696(08)62452-3
  28. Navarre Catherine, De Muynck Benoit, Alves Georges, Vertommen Didier, Magy Bertrand, Boutry Marc, Identification, gene cloning and expression of serine proteases in the extracellular medium of Nicotiana tabacum cells, 10.1007/s00299-012-1308-y
  29. Paul Matthew, Ma Julian K-C., Plant-made pharmaceuticals: Leading products and production platforms, 10.1002/bab.6
  30. Salfeld Jochen G, Isotype selection in antibody engineering, 10.1038/nbt1207-1369
  31. Schuurman Janine, Perdok Gerrard J, Gorter Annelies D, Aalberse Rob C, The inter-heavy chain disulfide bonds of IgG4 are in equilibrium with intra-chain disulfide bonds, 10.1016/s0161-5890(01)00050-5
  32. Sharp Janet M., Doran Pauline M., Characterization of monoclonal antibody fragments produced by plant cells, 10.1002/bit.1067
  33. Sharp J.M., Doran P.M., Strategies for Enhancing Monoclonal Antibody Accumulation in Plant Cell and Organ Cultures, 10.1021/bp010104t
  34. Sheridan Cormac, Fresh from the biologic pipeline—2009, 10.1038/nbt0410-307
  35. Tsoi Bonny M.-Y., Doran Pauline M., Effect of medium properties and additives on antibody stability and accumulation in suspended plant cell cultures, 10.1042/ba20010105
  36. Twyman Richard M., Schillberg Stefan, Fischer Rainer, The Production of Vaccines and Therapeutic Antibodies in Plants, Molecular Farming in Plants: Recent Advances and Future Prospects (2012) ISBN:9789400722163 p.145-159, 10.1007/978-94-007-2217-0_7
  37. Ullisch David A., Müller Christina A., Maibaum Sabrina, Kirchhoff Janina, Schiermeyer Andreas, Schillberg Stefan, Roberts Jean L., Treffenfeldt Wiltrud, Büchs Jochen, Comprehensive characterization of two different Nicotiana tabacum cell lines leads to doubled GFP and HA protein production by media optimization, 10.1016/j.jbiosc.2011.09.022
  38. Vasilev Nikolay, Grömping Ulrike, Lipperts Anja, Raven Nicole, Fischer Rainer, Schillberg Stefan, Optimization of BY-2 cell suspension culture medium for the production of a human antibody using a combination of fractional factorial designs and the response surface method, 10.1111/pbi.12079
  39. Whaley Kevin J., Hiatt Andrew, Zeitlin Larry, Emerging antibody products and Nicotiana manufacturing, 10.4161/hv.7.3.14266
  40. Xu Jianfeng, Ge Xumeng, Dolan Maureen C., Towards high-yield production of pharmaceutical proteins with plant cell suspension cultures, 10.1016/j.biotechadv.2011.01.002
  41. Xu Jianfeng, Dolan Maureen C., Medrano Giuliana, Cramer Carole L., Weathers Pamela J., Green factory: Plants as bioproduction platforms for recombinant proteins, 10.1016/j.biotechadv.2011.08.020
  42. Yusibov Vidadi, Streatfield Stephen J., Kushnir Natasha, Clinical development of plant-produced recombinant pharmaceuticals: Vaccines, antibodies and beyond, 10.4161/hv.7.3.14207