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Validation of anatomical models to study aerosol deposition in human nasal cavities

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LE GUELLEC, Sandrine [DFT-Aerodrug, Faculté de Médecine, Tours, France] LE PENNEC, Deborah [EA6305, Faculté de Médecine, Université François Rabelais, Tours, France] Gatier, Stéphane [DFT-Medical, Saint-Etienne, France] Leclerc, Lara [Ecole Nationale Supérieure des Mines, Saint-Etienne, France] Cabrera, Maria [EA6305, Faculté de Médecine, Université François Rabelais, Tours, France] Reychler, Gregory [UCL] Pitance, Laurent [UCL] Jamar, François [UCL] VECELLIO , Laurent [DFT-Aerodrug, Faculté de Médecine, Tours, France]

Purpose: Intranasal deposition of aerosols is often studied using in vitro nasal cavity models. However, the relevance of these models to predict in vivo human deposition has not been validated. This study compared in vivo nasal aerosol deposition and in vitro deposition in a human plastinated head model (NC1) and its replica constructed from CT-scan (NC2). Methods: Two nebulizers (Atomisor Sonique® and Easynose®) were used to administer a 5.6 μm aerosol of 99mTc-DTPA to seven healthy volunteers and to the nasal models. Aerosol deposition was quantified by γ-scintigraphy in the nasal, upper nasal cavity and maxillary sinus (MS) regions. The distribution of aerosol deposition was determined along three nasal cavity axes (x, y and z). Results: There was no significant difference regarding aerosol deposition between the volunteers and NC1. Aerosol deposition was significantly lower in NC2 than in volunteers regarding nasal region (p < 0.05) but was similar for the upper nasal cavity and MS regions. Mean aerosol distribution for NC1 came within the standard deviation (SD) of in vivo distribution, whereas that of NC2 was outside the in vivo SD for x and y axes. Conclusions: In conclusion, nasal models can be used to predict aerosol deposition produced by nebulizers, but their performance depends on their design.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2014
Language Anglais
Journal information "Pharmaceutical Research" - Vol. 31, no.1, p. 228-237 (Janvier 2014)
Peer reviewed yes
Publisher Springer New York LLC ((United States) New York)
issn 0724-8741
e-issn 1573-904X
Publication status Publié
Affiliations UCL - (SLuc) Service de pneumologie
UCL - (SLuc) Service de stomatologie et de chirurgie maxillo-faciale
UCL - (SLuc) Service de médecine nucléaire
UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience
Keywords aerosol ; anatomical model ; nasal ; nebulizer
Links
  1. Fokkens WJ, Lund VJ, Mullol J, Bachert C, Alobid I, et al. European position paper on rhinosinusitis and nasal polyps. Rhinol Suppl. 2012;3:1–298.
  2. Costantino Henry R., Illum Lisbeth, Brandt Gordon, Johnson Paul H., Quay Steven C., Intranasal delivery: Physicochemical and therapeutic aspects, 10.1016/j.ijpharm.2007.03.025
  3. Laube BL. The expanding role of aerosols in systemic drug delivery, gene therapy, and vaccination. Respir Care. 2005;50:1161–76.
  4. Costantino HR, Sileno AP, Johnson PH. Pharmacokinetic attributes of intranasal delivery: case studies and new opportunities. Drug Deliv. 2005;3:8–11.
  5. Grassin-Delyle Stanislas, Buenestado Amparo, Naline Emmanuel, Faisy Christophe, Blouquit-Laye Sabine, Couderc Louis-Jean, Le Guen Morgan, Fischler Marc, Devillier Philippe, Intranasal drug delivery: An efficient and non-invasive route for systemic administration, 10.1016/j.pharmthera.2012.03.003
  6. Illum Lisbeth, Is nose-to-brain transport of drugs in man a reality?, 10.1211/0022357022539
  7. Illum L., Intranasal Delivery of Morphine, 10.1124/jpet.301.1.391
  8. Banks W. A., Brain Uptake of the Glucagon-Like Peptide-1 Antagonist Exendin(9-39) after Intranasal Administration, 10.1124/jpet.103.063222
  9. Jogani Viral V., Shah Pranav J., Misra Ambikanandan R., Mishra Pushpa, Mishra Anil Kumar, Nose-to-brain delivery of tacrine, 10.1211/jpp.59.9.0003
  10. Jogani Viral V., Shah Pranav J., Mishra Pushpa, Mishra Anil Kumar, Misra Ambikanandan R., Intranasal Mucoadhesive Microemulsion of Tacrine to Improve Brain Targeting : , 10.1097/wad.0b013e318157205b
  11. Laube Beth L., Devices for Aerosol Delivery to Treat Sinusitis, 10.1089/jam.2007.0569
  12. Baroody FM. Nasal and paranasal sinus anatomy and physiology. Clin Allergy Immunol. 2007;19:1–21.
  13. Misra Ambikanandan, Jogani Viral, Jinturkar Kaustubh, Vyas Tushar, Recent Patents Review on Intranasal Administration for CNS Drug Delivery, 10.2174/187221108783331429
  14. Rapoport Alan M., The therapeutic future in headache, 10.1007/s10072-012-1056-3
  15. FDA Guidance for Industry. Nasal Spray and Inhalation Solution, Suspension, and Spray Drug Products - Chemistry, Manufacturing, and Controls Documentation.U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research.2002.
  16. Vecellio Laurent, De Gersem Ruth, Le Guellec Sandrine, Reychler Gregory, Pitance Laurent, Le Pennec Deborah, Diot Patrice, Chantrel Gilles, Bonfils Pierre, Jamar François, Deposition of aerosols delivered by nasal route with jet and mesh nebulizers, 10.1016/j.ijpharm.2011.01.024
  17. Valentine Rowan, Athanasiadis Theo, Thwin May, Singhal Deepti, Weitzel Erik K., Wormald Peter-John, A prospective controlled trial of pulsed nasal nebulizer in maximally dissected cadavers, 10.2500/ajr.2008.22.3191
  18. Durand M, Pourchez J, Louis B, Pouget JF, Isabey D, et al. Plastinated nasal model: a new concept of anatomically realistic cast. Rhinology. 2011;49:30–6.
  19. Möller W, Schuschnig U, Meyer G, Mentzel H, Keller M. Ventilation and drug delivery to the paranasal sinuses: studies in a nasal cast using pulsating airflow. Rhinology. 2008;46:213–20.
  20. Kundoor Vipra, Dalby Richard N., Assessment of Nasal Spray Deposition Pattern in a Silicone Human Nose Model Using a Color-Based Method, 10.1007/s11095-009-0002-4
  21. Kelly James T., Asgharian Bahman, Kimbell Julia S., Wong Brian A., Particle Deposition in Human Nasal Airway Replicas Manufactured by Different Methods. Part I: Inertial Regime Particles, 10.1080/027868290883360
  22. Janssens Hettie M., de Jongste Johan C., Fokkens Wytske J., Robben Simon G.F., Wouters Kris, Tiddens Harm A.W.M., The Sophia Anatomical Infant Nose-Throat (Saint) Model: A Valuable Tool to Study Aerosol Deposition in Infants, 10.1089/08942680152744640
  23. Meakin J R, Shepherd D E T, Hukins D W L, Fused deposition models from CT scans, 10.1259/bjr/50012454
  24. Schroeter Jeffry D., Garcia Guilherme J.M., Kimbell Julia S., Effects of surface smoothness on inertial particle deposition in human nasal models, 10.1016/j.jaerosci.2010.11.002
  25. Kublik H, Vidgren M.T, Nasal delivery systems and their effect on deposition and absorption, 10.1016/s0169-409x(97)00067-7
  26. Möller W, Saba GK, Haussinger K, Becker S, Keller M, Schuschnig U. Nasally inhaled pulsating aerosols: lung, sinus and nose deposition. Rhinology. 2011;49:286–91.
  27. Al Badaai Y, Samaha M, Outcome of endoscopic sinus surgery for chronic rhinosinusitis patients: a Canadian experience, 10.1017/s0022215110001003
  28. Day N., Mainardi J.-L., Malinvaud D., Bonfils P., Étude bactériologique des cavités d’ethmoïdectomie chez des patients ayant une polypose naso-sinusienne opérée, 10.1016/j.aorl.2009.06.004
  29. Woodhouse Brittany Mae, Cleveland Kevin W, Nebulized Antibiotics for the Treatment of Refractory Bacterial Chronic Rhinosinusitis, 10.1345/aph.1p723
  30. Durand Marc, Pourchez Jérémie, Aubert Gérald, Le Guellec Sandrine, Navarro Laurent, Forest Valérie, Rusch Philippe, Cottier Michèle, Impact of acoustic airflow nebulization on intrasinus drug deposition of a human plastinated nasal cast: New insights into the mechanisms involved, 10.1016/j.ijpharm.2011.09.023
Bibliographic reference LE GUELLEC, Sandrine ; LE PENNEC, Deborah ; Gatier, Stéphane ; Leclerc, Lara ; Cabrera, Maria ; et. al. Validation of anatomical models to study aerosol deposition in human nasal cavities. In: Pharmaceutical Research, Vol. 31, no.1, p. 228-237 (Janvier 2014)
Permanent URL http://hdl.handle.net/2078.1/139078