De Hertogh, René
[UCL]
Vankrieken, L.
de Gasparo, M
Thomas, Karl
[UCL]
The contribution of the ovary to the circulating total renin pool is linked to its secretory activity in relation with its reproductive function. In a longitudinal study of 13 normal women, total renin levels measured in serum by an immunoradiometric assay were lower in the midfollicular phase (180 +/- 59 pg/ml) than in the midluteal phase (291 +/- 100 pg/ml). Peak levels were encountered 1 day after the luteinizing hormone (LH) surge (375 +/- 97 pg/ml). Rapid circhoral fluctuations were observed in all periods of the cycle, unrelated to the LH pulses. In case of ovarian function inhibition (induced by gonadotropin-releasing hormone agonists), total renin levels were lower than in the midfollicular phase (126 +/- 56 pg/ml). Low levels also were encountered in the prepubertal period (153 +/- 89 pg/ml). Very high levels (17,600 +/- 11,400 pg/ml) were found in follicular fluids from stimulated cycles. These results show that circulating total renin levels follow a complex pattern in which LH, but possibly also follicle-stimulating hormone and gonadal steroid hormones (estradiol and progesterone), may play a role.
Bibliographic reference |
De Hertogh, René ; Vankrieken, L. ; de Gasparo, M ; Thomas, Karl. Immunoradiometric assays of total renin and gonadotropins in serum during the menstrual cycle.. In: Fertility and sterility, Vol. 52, no. 2, p. 209-15 (1989) |
Permanent URL |
http://hdl.handle.net/2078.1/13889 |