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Cyclophosphamide treatment induces rejection of established P815 mastocytoma by enhancing CD4 priming and intratumoral infiltration of P1E/H-2Kd -specific CD8+ T cells

Bibliographic reference Rahir, Gwendoline ; Wathelet, Nathalie ; Hanoteau, Aurélie ; Henin, Coralie ; Oldenhove, Guillaume ; et. al. Cyclophosphamide treatment induces rejection of established P815 mastocytoma by enhancing CD4 priming and intratumoral infiltration of P1E/H-2Kd -specific CD8+ T cells. In: International Journal of Cancer, Vol. 134, no. 12, p. 2841-2852 (January 2014)
Permanent URL http://hdl.handle.net/2078.1/136420
  1. Apetoh Lionel, Ghiringhelli François, Tesniere Antoine, Obeid Michel, Ortiz Carla, Criollo Alfredo, Mignot Grégoire, Maiuri M Chiara, Ullrich Evelyn, Saulnier Patrick, Yang Huan, Amigorena Sebastian, Ryffel Bernard, Barrat Franck J, Saftig Paul, Levi Francis, Lidereau Rosette, Nogues Catherine, Mira Jean-Paul, Chompret Agnès, Joulin Virginie, Clavel-Chapelon Françoise, Bourhis Jean, André Fabrice, Delaloge Suzette, Tursz Thomas, Kroemer Guido, Zitvogel Laurence, Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy, 10.1038/nm1622
  2. Casares Noelia, Pequignot Marie O., Tesniere Antoine, Ghiringhelli François, Roux Stéphan, Chaput Nathalie, Schmitt Elise, Hamai Ahmed, Hervas-Stubbs Sandra, Obeid Michel, Coutant Frédéric, Métivier Didier, Pichard Evelyne, Aucouturier Pierre, Pierron Gérard, Garrido Carmen, Zitvogel Laurence, Kroemer Guido, Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death, 10.1084/jem.20050915
  3. Denkert Carsten, Loibl Sibylle, Noske Aurelia, Roller Marc, Müller Berit Maria, Komor Martina, Budczies Jan, Darb-Esfahani Silvia, Kronenwett Ralf, Hanusch Claus, von Törne Christian, Weichert Wilko, Engels Knut, Solbach Christine, Schrader Iris, Dietel Manfred, von Minckwitz Gunter, Tumor-Associated Lymphocytes As an Independent Predictor of Response to Neoadjuvant Chemotherapy in Breast Cancer, 10.1200/jco.2009.23.7370
  4. Galon J., Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome, 10.1126/science.1129139
  5. Gianni Luca, Zambetti Milvia, Clark Kim, Baker Joffre, Cronin Maureen, Wu Jenny, Mariani Gabriella, Rodriguez Jaime, Carcangiu Marialuisa, Watson Drew, Valagussa Pinuccia, Rouzier Roman, Symmans W. Fraser, Ross Jeffrey S., Hortobagyi Gabriel N., Pusztai Lajos, Shak Steven, Gene Expression Profiles in Paraffin-Embedded Core Biopsy Tissue Predict Response to Chemotherapy in Women With Locally Advanced Breast Cancer, 10.1200/jco.2005.02.0818
  6. Nosho Katsuhiko, Baba Yoshifumi, Tanaka Noriko, Shima Kaori, Hayashi Marika, Meyerhardt Jeffrey A, Giovannucci Edward, Dranoff Glenn, Fuchs Charles S, Ogino Shuji, Tumour-infiltrating T-cell subsets, molecular changes in colorectal cancer, and prognosis: cohort study and literature review, 10.1002/path.2774
  7. Pagès Franck, Berger Anne, Camus Matthieu, Sanchez-Cabo Fatima, Costes Anne, Molidor Robert, Mlecnik Bernhard, Kirilovsky Amos, Nilsson Malin, Damotte Diane, Meatchi Tchao, Bruneval Patrick, Cugnenc Paul-Henri, Trajanoski Zlatko, Fridman Wolf-Herman, Galon Jérôme, Effector Memory T Cells, Early Metastasis, and Survival in Colorectal Cancer, 10.1056/nejmoa051424
  8. Sato E., Olson S. H., Ahn J., Bundy B., Nishikawa H., Qian F., Jungbluth A. A., Frosina D., Gnjatic S., Ambrosone C., Kepner J., Odunsi T., Ritter G., Lele S., Chen Y.-T., Ohtani H., Old L. J., Odunsi K., Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer, 10.1073/pnas.0509182102
  9. Zhang Lin, Conejo-Garcia Jose R., Katsaros Dionyssios, Gimotty Phyllis A., Massobrio Marco, Regnani Giorgia, Makrigiannakis Antonis, Gray Heidi, Schlienger Katia, Liebman Michael N., Rubin Stephen C., Coukos George, Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer, 10.1056/nejmoa020177
  10. Rakhra Kavya, Bachireddy Pavan, Zabuawala Tahera, Zeiser Robert, Xu Liwen, Kopelman Andrew, Fan Alice C., Yang Qiwei, Braunstein Lior, Crosby Erika, Ryeom Sandra, Felsher Dean W., CD4+ T Cells Contribute to the Remodeling of the Microenvironment Required for Sustained Tumor Regression upon Oncogene Inactivation, 10.1016/j.ccr.2010.10.002
  11. Hengst, Cancer Res, 41, 2163 (1981)
  12. Awwad, Immunology, 65, 87 (1988)
  13. North R. J., Cyclophosphamide-facilitated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cells, 10.1084/jem.155.4.1063
  14. North R. J., Generation and decay of the immune response to a progressive fibrosarcoma. I. Ly-1+2- suppressor T cells down-regulate the generation of Ly-1-2+ effector T cells, 10.1084/jem.159.5.1295
  15. Ibe Sabrina, Qin Zhihai, Schüler Thomas, Preiss Susanne, Blankenstein Thomas, Tumor Rejection by Disturbing Tumor Stroma Cell Interactions, 10.1084/jem.194.11.1549
  16. Wada S., Yoshimura K., Hipkiss E. L., Harris T. J., Yen H.-R., Goldberg M. V., Grosso J. F., Getnet D., Demarzo A. M., Netto G. J., Anders R., Pardoll D. M., Drake C. G., Cyclophosphamide Augments Antitumor Immunity: Studies in an Autochthonous Prostate Cancer Model, 10.1158/0008-5472.can-08-4102
  17. Hirschhorn-Cymerman Daniel, Rizzuto Gabrielle A., Merghoub Taha, Cohen Adam D., Avogadri Francesca, Lesokhin Alexander M., Weinberg Andrew D., Wolchok Jedd D., Houghton Alan N., OX40 engagement and chemotherapy combination provides potent antitumor immunity with concomitant regulatory T cell apoptosis, 10.1084/jem.20082205
  18. Schiavoni G., Sistigu A., Valentini M., Mattei F., Sestili P., Spadaro F., Sanchez M., Lorenzi S., D'Urso M. T., Belardelli F., Gabriele L., Proietti E., Bracci L., Cyclophosphamide Synergizes with Type I Interferons through Systemic Dendritic Cell Reactivation and Induction of Immunogenic Tumor Apoptosis, 10.1158/0008-5472.can-10-2788
  19. Reits Eric A., Hodge James W., Herberts Carla A., Groothuis Tom A., Chakraborty Mala, K.Wansley Elizabeth, Camphausen Kevin, Luiten Rosalie M., de Ru Arnold H., Neijssen Joost, Griekspoor Alexander, Mesman Elly, Verreck Frank A., Spits Hergen, Schlom Jeffrey, van Veelen Peter, Neefjes Jacques J., Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy, 10.1084/jem.20052494
  20. Galluzzi Lorenzo, Senovilla Laura, Zitvogel Laurence, Kroemer Guido, The secret ally: immunostimulation by anticancer drugs, 10.1038/nrd3626
  21. Zitvogel Laurence, Apetoh Lionel, Ghiringhelli François, Kroemer Guido, Immunological aspects of cancer chemotherapy, 10.1038/nri2216
  22. Huijbers I. J., Soudja S. M., Uyttenhove C., Buferne M., Inderberg-Suso E.-M., Colau D., Pilotte L., Powis de Tenbossche C. G., Chomez P., Brasseur F., Schmitt-Verhulst A.-M., Van den Eynde B. J., Minimal Tolerance to a Tumor Antigen Encoded by a Cancer-Germline Gene, 10.4049/jimmunol.1002612
  23. Hong M., Puaux A.-L., Huang C., Loumagne L., Tow C., Mackay C., Kato M., Prevost-Blondel A., Avril M.-F., Nardin A., Abastado J.-P., Chemotherapy Induces Intratumoral Expression of Chemokines in Cutaneous Melanoma, Favoring T-cell Infiltration and Tumor Control, 10.1158/0008-5472.can-11-1466
  24. Oldenhove Guillaume, de Heusch Magali, Urbain-Vansanten Georgette, Urbain Jacques, Maliszewski Charlie, Leo Oberdan, Moser Muriel, CD4+CD25+Regulatory T Cells Control T Helper Cell Type 1 Responses to Foreign Antigens Induced by Mature Dendritic Cells In Vivo, 10.1084/jem.20030654
  25. Bilsborough J., Uyttenhove C., Colau D., Bousso P., Libert C., Weynand B., Boon T., Van den Eynde B. J., TNF-Mediated Toxicity After Massive Induction of Specific CD8+ T Cells Following Immunization of Mice with a Tumor-Specific Peptide, 10.4049/jimmunol.169.6.3053
  26. Flamand Véronique, Biernaux Cécile, Van Mechelen Marcelle, Sornasse Thierry, Urbain Jacques, Leo Oberdan, Moser Muriel, Immune surveillance: Both CD3+ CD4+ and CD3+ CD8+ T cells controlin vivo growth of P815 mastocytoma, 10.1002/ijc.2910450431
  27. Ghiringhelli François, Larmonier Nicolas, Schmitt Elise, Parcellier Arnaud, Cathelin Dominique, Garrido Carmen, Chauffert Bruno, Solary Eric, Bonnotte Bernard, Martin François, CD4+CD25+ regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative, 10.1002/eji.200324181
  28. Ghiringhelli François, Menard Cedric, Puig Pierre Emmanuel, Ladoire Sylvain, Roux Stephan, Martin François, Solary Eric, Le Cesne Axel, Zitvogel Laurence, Chauffert Bruno, Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients, 10.1007/s00262-006-0225-8
  29. Lutsiak M. E. C., Inhibition of CD4+25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide, 10.1182/blood-2004-06-2410
  30. Van den Eynde B., The gene coding for a major tumor rejection antigen of tumor P815 is identical to the normal gene of syngeneic DBA/2 mice, 10.1084/jem.173.6.1373
  31. Bilsborough, J Immunol, 162, 3534 (1999)
  32. Brändle Daniel, Bilsborough Janine, Rülicke Thomas, Uyttenhove Catherine, Boon Thierry, Van den Eynde Benoît J., The shared tumor-specific antigen encoded by mouse geneP1A is a target not only for cytolytic T lymphocytes but also for tumor rejection, 10.1002/(sici)1521-4141(199812)28:12<4010::aid-immu4010>3.0.co;2-5
  33. Rahir Gwendoline, Moser Muriel, Tumor microenvironment and lymphocyte infiltration, 10.1007/s00262-012-1253-1
  34. Ciampricotti Metamia, Hau Cheei-Sing, Doornebal Chris W, Jonkers Jos, de Visser Karin E, Chemotherapy response of spontaneous mammary tumors is independent of the adaptive immune system, 10.1038/nm.2652
  35. Bianchi, J Immunol, 157, 1589 (1996)
  36. Nakanishi Yusuke, Lu Bao, Gerard Craig, Iwasaki Akiko, CD8+ T lymphocyte mobilization to virus-infected tissue requires CD4+ T-cell help, 10.1038/nature08511
  37. Castellino Flora, Huang Alex Y., Altan-Bonnet Grégoire, Stoll Sabine, Scheinecker Clemens, Germain Ronald N., Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell–dendritic cell interaction, 10.1038/nature04651
  38. Kumamoto Y., Mattei L. M., Sellers S., Payne G. W., Iwasaki A., CD4+ T cells support cytotoxic T lymphocyte priming by controlling lymph node input, 10.1073/pnas.1100567108
  39. Bos R., Sherman L. A., CD4+ T-Cell Help in the Tumor Milieu Is Required for Recruitment and Cytolytic Function of CD8+ T Lymphocytes, 10.1158/0008-5472.can-10-1322
  40. Wong S. B. J., Bos R., Sherman L. A., Tumor-Specific CD4+ T Cells Render the Tumor Environment Permissive for Infiltration by Low-Avidity CD8+ T Cells, 10.4049/jimmunol.180.5.3122
  41. Ma Yuting, Adjemian Sandy, Mattarollo Stephen R., Yamazaki Takahiro, Aymeric Laetitia, Yang Heng, Portela Catani João Paulo, Hannani Dalil, Duret Helene, Steegh Kim, Martins Isabelle, Schlemmer Frederic, Michaud Mickaël, Kepp Oliver, Sukkurwala Abdul Qader, Menger Laurie, Vacchelli Erika, Droin Nathalie, Galluzzi Lorenzo, Krzysiek Roman, Gordon Siamon, Taylor Philip R., Van Endert Peter, Solary Eric, Smyth Mark J., Zitvogel Laurence, Kroemer Guido, Anticancer Chemotherapy-Induced Intratumoral Recruitment and Differentiation of Antigen-Presenting Cells, 10.1016/j.immuni.2013.03.003
  42. Hildner K., Edelson B. T., Purtha W. E., Diamond M., Matsushita H., Kohyama M., Calderon B., Schraml B. U., Unanue E. R., Diamond M. S., Schreiber R. D., Murphy T. L., Murphy K. M., Batf3 Deficiency Reveals a Critical Role for CD8 + Dendritic Cells in Cytotoxic T Cell Immunity, 10.1126/science.1164206
  43. Segura E., Albiston A. L., Wicks I. P., Chai S. Y., Villadangos J. A., Different cross-presentation pathways in steady-state and inflammatory dendritic cells, 10.1073/pnas.0910295106
  44. Scarlett Uciane K., Rutkowski Melanie R., Rauwerdink Adam M., Fields Jennifer, Escovar-Fadul Ximena, Baird Jason, Cubillos-Ruiz Juan R., Jacobs Ana C., Gonzalez Jorge L., Weaver John, Fiering Steven, Conejo-Garcia Jose R., Ovarian cancer progression is controlled by phenotypic changes in dendritic cells, 10.1084/jem.20111413
  45. Norian L. A., Rodriguez P. C., O'Mara L. A., Zabaleta J., Ochoa A. C., Cella M., Allen P. M., Tumor-Infiltrating Regulatory Dendritic Cells Inhibit CD8+ T Cell Function via L-Arginine Metabolism, 10.1158/0008-5472.can-08-2826
  46. Engelhardt John J., Boldajipour Bijan, Beemiller Peter, Pandurangi Priya, Sorensen Caitlin, Werb Zena, Egeblad Mikala, Krummel Matthew F., Marginating Dendritic Cells of the Tumor Microenvironment Cross-Present Tumor Antigens and Stably Engage Tumor-Specific T Cells, 10.1016/j.ccr.2012.01.008
  47. Pelaez B., Campillo J. A., Lopez-Asenjo J. A., Subiza J. L., Cyclophosphamide Induces the Development of Early Myeloid Cells Suppressing Tumor Cell Growth by a Nitric Oxide-Dependent Mechanism, 10.4049/jimmunol.166.11.6608
  48. Salem M. L., Diaz-Montero C. M., Al-Khami A. A., El-Naggar S. A., Naga O., Montero A. J., Khafagy A., Cole D. J., Recovery from Cyclophosphamide-Induced Lymphopenia Results in Expansion of Immature Dendritic Cells Which Can Mediate Enhanced Prime-Boost Vaccination Antitumor Responses In Vivo When Stimulated with the TLR3 Agonist Poly(I:C), 10.4049/jimmunol.0801829
  49. Salem Mohamed L., El-Naggar Sabry A., Cole David J., Cyclophosphamide induces bone marrow to yield higher numbers of precursor dendritic cells in vitro capable of functional antigen presentation to T cells in vivo, 10.1016/j.cellimm.2009.11.011
  50. Nakahara T., Uchi H., Lesokhin A. M., Avogadri F., Rizzuto G. A., Hirschhorn-Cymerman D., Panageas K. S., Merghoub T., Wolchok J. D., Houghton A. N., Cyclophosphamide enhances immunity by modulating the balance of dendritic cell subsets in lymphoid organs, 10.1182/blood-2009-11-251231
  51. Sistigu Antonella, Viaud Sophie, Chaput Nathalie, Bracci Laura, Proietti Enrico, Zitvogel Laurence, Immunomodulatory effects of cyclophosphamide and implementations for vaccine design, 10.1007/s00281-011-0245-0
  52. Finkelman Fred D., Shea-Donohue Terez, Morris Suzanne C., Gildea Lucy, Strait Richard, Madden Kathleen B., Schopf Lisa, Urban Joseph F., Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites, 10.1111/j.0105-2896.2004.00192.x