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Effect of interferon-alpha-based antiviral therapy on hepatitis C virus-associated glomerulonephritis: a meta-analysis.

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Feng, Bo Eknoyan, Garabed Guo, Zhong-Sheng Jadoul, Michel [UCL] Rao, Hui-Ying Wei, Lai

Antiviral therapy based on IFNα can significantly decrease proteinuria and stabilize serum creatitine, and therefore, should be undertaken in patients with HCV-associated glomerulonephritis. The improvement in protein excretion is greater in those who achieve HCV RNA clearance, a finding in line with a causal role for HCV in glomerulonephritis.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2012
Language Anglais
Journal information "Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association" - Vol. 27, no. 2, p. 640-646 (2012)
Peer reviewed yes
issn 1460-2385
e-issn 0931-0509
Publication status Publié
Affiliations UCL - SSS/IREC/NEFR - Pôle de Néphrologie
UCL - (SLuc) Service de néphrologie
MESH Subject Antiviral Agents ; Glomerulonephritis ; Hepacivirus ; Hepatitis C ; Humans ; Interferon-alpha ; Male ; Randomized Controlled Trials as Topic ; Risk Assessment ; Severity of Illness Index ; Treatment Outcome ; Comorbidity ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Drug Therapy, Combination ; Evidence-Based Medicine ; Female ; Follow-Up Studies ; Glomerular Filtration Rate
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Bibliographic reference Feng, Bo ; Eknoyan, Garabed ; Guo, Zhong-Sheng ; Jadoul, Michel ; Rao, Hui-Ying ; et. al. Effect of interferon-alpha-based antiviral therapy on hepatitis C virus-associated glomerulonephritis: a meta-analysis.. In: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Vol. 27, no. 2, p. 640-646 (2012)
Permanent URL http://hdl.handle.net/2078.1/135303