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Hypoxia integration in the serological proteome analysis unmasks tumor antigens and fosters the identification of anti-phospho-eEF2 antibodies as potential cancer biomarkers

Bibliographic reference Grandjean, Marie ; Sermeus, Alexandra ; Branders, Samuel ; Defresne, Florence ; Dieu, Marc ; et. al. Hypoxia integration in the serological proteome analysis unmasks tumor antigens and fosters the identification of anti-phospho-eEF2 antibodies as potential cancer biomarkers. In: PLoS One, Vol. 8, no. 10, p. e76508 [1-10] (2013)
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  1. Hanahan Douglas, Weinberg Robert A., Hallmarks of Cancer: The Next Generation, 10.1016/j.cell.2011.02.013
  2. Dewhirst Mark W., Cao Yiting, Moeller Benjamin, Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response, 10.1038/nrc2397
  3. Vaupel Peter, Mayer Arnulf, Hypoxia in cancer: significance and impact on clinical outcome, 10.1007/s10555-007-9055-1
  4. Bertout Jessica A., Patel Shetal A., Simon M. Celeste, The impact of O2 availability on human cancer, 10.1038/nrc2540
  5. Pries Axel R., Höpfner Michael, le Noble Ferdinand, Dewhirst Mark W., Secomb Timothy W., The shunt problem: control of functional shunting in normal and tumour vasculature, 10.1038/nrc2895
  6. Harris Adrian L., HYPOXIA — A KEY REGULATORY FACTOR IN TUMOUR GROWTH, 10.1038/nrc704
  7. Vincent K, Harnessing the Response to Tissue Hypoxia HIF-1α and Therapeutic Angiogenesis, 10.1016/s1050-1738(02)00186-x
  8. Bristow Robert G., Hill Richard P., Hypoxia and metabolism: Hypoxia, DNA repair and genetic instability, 10.1038/nrc2344
  9. Wouters Bradly G., Koritzinsky Marianne, Hypoxia signalling through mTOR and the unfolded protein response in cancer, 10.1038/nrc2501
  10. Daneau G., Boidot R., Martinive P., Feron O., Identification of Cyclooxygenase-2 as a Major Actor of the Transcriptomic Adaptation of Endothelial and Tumor Cells to Cyclic Hypoxia: Effect on Angiogenesis and Metastases, 10.1158/1078-0432.ccr-09-0583
  11. Fang Jennifer S., Gillies Robert D., Gatenby Robert A., Adaptation to hypoxia and acidosis in carcinogenesis and tumor progression, 10.1016/j.semcancer.2008.03.011
  12. Robinson Andreas, Keely Simon, Karhausen Jörn, Gerich Mark E., Furuta Glenn T., Colgan Sean P., Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition, 10.1053/j.gastro.2007.09.033
  13. Simiantonaki Nektaria, Taxeidis Marios, Jayasinghe Caren, Kurzik-Dumke Ursula, Kirkpatrick Charles James, Hypoxia-inducible factor 1 alpha expression increases during colorectal carcinogenesis and tumor progression, 10.1186/1471-2407-8-320
  14. Mariani Francesco, Sena Paola, Marzona Laura, Riccio Massimo, Fano Rita, Manni Paola, Gregorio Carmela Di, Pezzi Annalisa, Leon Maurizio Ponz de, Monni Sebastiano, Pol Anto De, Roncucci Luca, Cyclooxygenase-2 and Hypoxia-Inducible Factor-1α protein expression is related to inflammation, and up-regulated since the early steps of colorectal carcinogenesis, 10.1016/j.canlet.2009.02.001
  15. Xue X., Taylor M., Anderson E., Hao C., Qu A., Greenson J. K., Zimmermann E. M., Gonzalez F. J., Shah Y. M., Hypoxia-Inducible Factor-2  Activation Promotes Colorectal Cancer Progression by Dysregulating Iron Homeostasis, 10.1158/0008-5472.can-11-3836
  16. Rosenberg Steven A., 10.1038/35077246
  17. Yewdell Jonathan W., Reits Eric, Neefjes Jacques, Making sense of mass destruction: quantitating MHC class I antigen presentation, 10.1038/nri1250
  18. Reits Eric, Neijssen Joost, Herberts Carla, Benckhuijsen Willemien, Janssen Lennert, Drijfhout Jan Wouter, Neefjes Jacques, A Major Role for TPPII in Trimming Proteasomal Degradation Products for MHC Class I Antigen Presentation, 10.1016/s1074-7613(04)00074-3
  19. Anderson Karen S., LaBaer Joshua, The Sentinel Within:  Exploiting the Immune System for Cancer Biomarkers†, 10.1021/pr0500814
  20. Tan Eng M., Zhang Jianying, Autoantibodies to tumor-associated antigens: reporters from the immune system, 10.1111/j.1600-065x.2008.00611.x
  21. Desmetz C., Cortijo C., Mangé A., Solassol J., Humoral response to cancer as a tool for biomarker discovery, 10.1016/j.jprot.2009.06.004
  22. Reuschenbach Miriam, von Knebel Doeberitz Magnus, Wentzensen Nicolas, A systematic review of humoral immune responses against tumor antigens, 10.1007/s00262-009-0733-4
  23. T Soussi, Cancer Res, 60, 1777 (2000)
  24. Kobold Sebastian, Lütkens Tim, Cao Yanran, Bokemeyer Carsten, Atanackovic Djordje, Autoantibodies against tumor-related antigens: Incidence and biologic significance, 10.1016/j.humimm.2010.03.015
  25. Desmetz Caroline, Maudelonde Thierry, Mangé Alain, Solassol Jerome, Identifying autoantibody signatures in cancer: a promising challenge, 10.1586/epr.09.56
  26. Lacombe Jérôme, Azria David, Mange Alain, Solassol Jérôme, Proteomic approaches to identify biomarkers predictive of radiotherapy outcomes, 10.1586/epr.12.68
  27. Tan Hwee Tong, Low Jiayi, Lim Seng Gee, Chung Maxey C. M., Serum autoantibodies as biomarkers for early cancer detection : Serum autoantibodies as diagnostic biomarkers, 10.1111/j.1742-4658.2009.07396.x
  28. Gunawardana C. Geeth, Diamandis Eleftherios P., High throughput proteomic strategies for identifying tumour-associated antigens, 10.1016/j.canlet.2007.01.002
  29. Lloyd S., Least squares quantization in PCM, 10.1109/tit.1982.1056489
  30. Y Benjamini, J R Stat Soc, 57, 289 (1995)
  31. REDPATH Nicholas T., PRICE Nigel T., SEVERINOV Konstantin V., PROUD Christopher G., Regulation of elongation factor-2 by multisite phosphorylation, 10.1111/j.1432-1033.1993.tb17809.x
  32. Connolly E., Braunstein S., Formenti S., Schneider R. J., Hypoxia Inhibits Protein Synthesis through a 4E-BP1 and Elongation Factor 2 Kinase Pathway Controlled by mTOR and Uncoupled in Breast Cancer Cells, 10.1128/mcb.26.10.3955-3965.2006
  33. Romero-Ruiz Antonio, Bautista Lucía, Navarro Virginia, Heras-Garvín Antonio, March-Díaz Rosana, Castellano Antonio, Gómez-Díaz Raquel, Castro María J., Berra Edurne, López-Barneo José, Pascual Alberto, Prolyl Hydroxylase-dependent Modulation of Eukaryotic Elongation Factor 2 Activity and Protein Translation under Acute Hypoxia, 10.1074/jbc.m111.299180
  34. Horman Sandrine, Browne Gareth J., Krause Ulrike, Patel Jigna V., Vertommen Didier, Bertrand Luc, Lavoinne Alain, Hue Louis, Proud Christopher G., Rider Mark H., Activation of AMP-Activated Protein Kinase Leads to the Phosphorylation of Elongation Factor 2 and an Inhibition of Protein Synthesis, 10.1016/s0960-9822(02)01077-1
  35. Ladd J. J., Chao T., Johnson M. M., Qiu J., Chin A., Israel R., Pitteri S. J., Mao J., Wu M., Amon L. M., McIntosh M., Li C., Prentice R., Disis N., Hanash S., Autoantibody Signatures Involving Glycolysis and Splicesome Proteins Precede a Diagnosis of Breast Cancer among Postmenopausal Women, 10.1158/0008-5472.can-12-2560
  36. Arora Sonia, Yang Jin-Ming, Craft Joseph, Hait William, Detection of anti-elongation factor 2 kinase (calmodulin-dependent protein kinase III) antibodies in patients with systemic lupus erythematosus, 10.1016/s0006-291x(02)00324-8