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RGD-conjugated triarylmethyl radical as probe for electron paramagnetic imaging

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Driesschaert, Benoît [UCL] Levêque, Philippe [UCL] Gallez, Bernard [UCL] Marchand-Brynaert, Jacqueline [UCL]

A stable RGD-conjugated triarylmethyl (TAM) radical 3 has been synthesized in a straightforward three-step sequence. CT-03 ‘the Finland trityl’ which is a very popular contrast agent for electron paramagnetic resonance imaging has been covalently bound to the NH2-ending of a pentapeptide commonly used to target integrins and confers tissue selectivity. Moreover, this new TAM radical is stable and sensitive to molecular oxygen.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2013
Language Anglais
Journal information "Tetrahedron Letters" - Vol. 54, no.44, p. 5924-5926 (2013)
Peer reviewed yes
Publisher Pergamon ((United Kingdom) Kidlington)
issn 0040-4039
e-issn 1873-3581
Publication status Publié
Affiliations UCL - SSS/LDRI - Louvain Drug Research Institute
UCL - SST/IMCN/MOST - Molecules, Solids and Reactivity
Keywords EPR ; Trityl radical ; Oximetry ; RGD
Links
Bibliographic reference Driesschaert, Benoît ; Levêque, Philippe ; Gallez, Bernard ; Marchand-Brynaert, Jacqueline. RGD-conjugated triarylmethyl radical as probe for electron paramagnetic imaging. In: Tetrahedron Letters, Vol. 54, no.44, p. 5924-5926 (2013)
Permanent URL http://hdl.handle.net/2078.1/134729