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Occurrence, in Crohn's disease, of antibodies directed against a species-specific recombinant polypeptide of Mycobacterium paratuberculosis

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Vannuffel, Pascal Dieterich, Christine Naerhuyzen, Bénédicte Gilot, Philippe Coene, Marc Fiasse, René [UCL] Cocito, Carlo [UCL]

Sera from patients with Crohn's disease and control were analyzed by an enzyme-linked immunosorbent assay based on the Mycobacterium paratuberculosis-specific recombinant polypeptide a362. Anti-a362 immunoglobulin G (IgG) (P < 0.05) and IgA (P < 0.001) titers were higher in patients with Crohn's disease than in controls. A monomodal Gaussian distribution of anti-a362 IgA levels were found for controls, and a bimodal distribution was found for patients with Crohn's disease. An M. paratuberculosis etiology is suggested for the 36% of patients with Crohn's disease who had an anti-a362 IgA level higher than that of controls.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 1994
Journal information "Clinical and Diagnostic Laboratory Immunology" - Vol. 1, no. 2, p. 241-243 (1994)
Peer reviewed yes
Publisher American Society for Microbiology
issn 1071-412X
Publication status Publié
Affiliations UCL - MD/MINT - Département de médecine interne
UCL - (SLuc) Service d'hépato-gastro-entérologie
MESH Subject Antibodies, Bacterial - chemistry ; Antigens, Bacterial - immunology ; Crohn Disease - immunology - microbiology ; Humans ; Mycobacterium avium subsp. paratuberculosis - immunology ; Peptides - immunology ; Recombinant Proteins - immunology ; Species Specificity
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Bibliographic reference Vannuffel, Pascal ; Dieterich, Christine ; Naerhuyzen, Bénédicte ; Gilot, Philippe ; Coene, Marc ; et. al. Occurrence, in Crohn's disease, of antibodies directed against a species-specific recombinant polypeptide of Mycobacterium paratuberculosis. In: Clinical and Diagnostic Laboratory Immunology, Vol. 1, no. 2, p. 241-243 (1994)
Permanent URL http://hdl.handle.net/2078.1/13472