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Hellebrin and its aglycone form hellebrigenin display similar in vitro growth inhibitory effects in cancer cells and binding profiles to the alpha subunits of the Na+/K+-ATPase.

Bibliographic reference Moreno Y Banuls, Laetitia ; Katz, Adriana ; Miklos, Walter ; Cimmino, Alessio ; Tal, Daniel M ; et. al. Hellebrin and its aglycone form hellebrigenin display similar in vitro growth inhibitory effects in cancer cells and binding profiles to the alpha subunits of the Na+/K+-ATPase.. In: Molecular Cancer, Vol. 12, p. 33 (2013)
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  1. Pardo L.A., Gomez-Varela D., Major F., Sansuk K., Leurs R., Downie B.R., Tietze L.F., Stuhmer W., Approaches Targeting KV10.1 Open a Novel Window for Cancer Diagnosis and Therapy, 10.2174/092986712798992011
  2. Prassas Ioannis, Diamandis Eleftherios P., Novel therapeutic applications of cardiac glycosides, 10.1038/nrd2682
  3. Mijatovic T., Dufrasne F., Kiss R., Cardiotonic Steroids-Mediated Targeting of the Na+/K+-ATPase to Combat Chemoresistant Cancers, 10.2174/092986712798992075
  4. Katz Adriana, Lifshitz Yael, Bab-Dinitz Elizabeta, Kapri-Pardes Einat, Goldshleger Rivka, Tal Daniel M., Karlish Steven J. D., Selectivity of Digitalis Glycosides for Isoforms of Human Na,K-ATPase, 10.1074/jbc.m110.119248
  5. Artigas P., Gadsby D. C., Ouabain affinity determining residues lie close to the Na/K pump ion pathway, 10.1073/pnas.0602720103
  6. Liang Man, Tian Jiang, Liu Lijun, Pierre Sandrine, Liu Jiang, Shapiro Joseph, Xie Zi-Jian, Identification of a Pool of Non-pumping Na/K-ATPase, 10.1074/jbc.m609181200
  7. Xie Zijian, Askari Amir, Na+/K+-ATPase as a signal transducer : Na+/K+-ATPase as a signal transducer, 10.1046/j.1432-1033.2002.02910.x
  8. Wang Haojie, Haas Michael, Liang Man, Cai Ting, Tian Jiang, Li Shengwen, Xie Zijian, Ouabain Assembles Signaling Cascades through the Caveolar Na+/K+-ATPase, 10.1074/jbc.m313239200
  9. Lefranc Florence, Mijatovic Tatjana, Kondo Yasuko, Sauvage Sébastien, Roland Isabelle, Debeir Olivier, Krstic Danijela, Vasic Vesna, Gailly Philippe, Kondo Seiji, Blanco Gustavo, Kiss Robert, TARGETING THE α 1 SUBUNIT OF THE SODIUM PUMP TO COMBAT GLIOBLASTOMA CELLS, 10.1227/01.neu.0000311080.43024.0e
  10. Mijatovic T, Roland I, Van Quaquebeke E, Nilsson B, Mathieu A, Van Vynckt F, Darro F, Blanco G, Facchini V, Kiss R, The α1 subunit of the sodium pump could represent a novel target to combat non-small cell lung cancers, 10.1002/path.2172
  11. Platz Elizabeth A., Yegnasubramanian Srinivasan, Liu Jun O., Chong Curtis R., Shim Joong Sup, Kenfield Stacey A., Stampfer Meir J., Willett Walter C., Giovannucci Edward, Nelson William G., A Novel Two-Stage, Transdisciplinary Study Identifies Digoxin as a Possible Drug for Prostate Cancer Treatment, 10.1158/
  12. Mathieu Véronique, Pirker Christine, Martin de Lassalle Elisabeth, Vernier Mathieu, Mijatovic Tatjana, DeNeve Nancy, Gaussin Jean-François, Dehoux Mischael, Lefranc Florence, Berger Walter, Kiss Robert, The sodium pump α1 sub-unit: a disease progression-related target for metastatic melanoma treatment, 10.1111/j.1582-4934.2009.00708.x
  13. Sakai Hideki, Suzuki Tomoyuki, Maeda Mizuki, Takahashi Yuji, Horikawa Naoki, Minamimura Tetsuji, Tsukada Kazuhiro, Takeguchi Noriaki, Up-regulation of Na+,K+-ATPase α3-isoform and down-regulation of the α1-isoform in human colorectal cancer, 10.1016/s0014-5793(04)00292-3
  14. Shibuya Kazuto, Fukuoka Junya, Fujii Takuto, Shimoda Eri, Shimizu Takahiro, Sakai Hideki, Tsukada Kazuhiro, Increase in ouabain-sensitive K+-ATPase activity in hepatocellular carcinoma by overexpression of Na+,K+-ATPase α3-isoform, 10.1016/j.ejphar.2010.04.029
  16. Karkare Sampada, Adou Eba, Cao Shugeng, Brodie Peggy, Miller James S., Andrianjafy N. M., Razafitsalama J., Andriantsiferana Rabodo, Rasamison Vincent E., Kingston David G. I., Cytotoxic Cardenolide Glycosides ofRoupellina (Strophanthus) boiviniifrom the Madagascar Rainforest(1), 10.1021/np070336n
  17. Krenn Liselotte, Jambrits Martina, Kopp Brigitte, Bufadienolide ausUrginea hesperia, 10.1055/s-2006-962412
  18. Krenn Liselotte, Ferth Roland, Robien Wolfgang, Kopp Brigitte, Bufadienolide ausUrginea maritima sensu strictu1, 10.1055/s-2006-960206
  19. Krenn Liselotte, Kopp Brigitte, Deim Andrea, Robien Wolfgang, Kubelka Wolfgang, Zum Bufadienolidmuster der roten „Meerzwiebel”1, 10.1055/s-2006-959410
  20. Gao Huimin, Zehl Martin, Kaehlig Hanspeter, Schneider Peter, Stuppner Hermann, Moreno Y. Banuls Laetitia, Kiss Robert, Kopp Brigitte, Rapid Structural Identification of Cytotoxic Bufadienolide Sulfates in Toad Venom fromBufo melanosticusby LC-DAD-MSnand LC-SPE-NMR, 10.1021/np900746k
  21. Lifshitz Yael, Petrovich Ekaterina, Haviv Haim, Goldshleger Rivka, Tal Daniel M., Garty Haim, Karlish Steven J. D., Purification of the Human α2 Isoform of Na,K-ATPase Expressed inPichia pastoris.Stabilization by Lipids and FXYD1†, 10.1021/bi701812c
  22. Yang P., Menter D. G., Cartwright C., Chan D., Dixon S., Suraokar M., Mendoza G., Llansa N., Newman R. A., Oleandrin-mediated inhibition of human tumor cell proliferation: Importance of Na,K-ATPase   subunits as drug targets, 10.1158/1535-7163.mct-08-1085
  23. Mathieu Anne, Remmelink Myriam, D'Haene Nicky, Penant Stanislas, Gaussin Jean-François, Van Ginckel Rob, Darro Francis, Kiss Robert, Salmon Isabelle, Development of a chemoresistant orthotopic human nonsmall cell lung carcinoma model in nude mice : Analyses of tumor heterogeneity in relation to the immunohistochemical levels of expression of cyclooxygenase-2, ornithine decarboxylase, lung-related resistance protein, prostaglandin E synthetase, and glutathione-S-transferase(GST)-α, GST-μ, and GST-π, 10.1002/cncr.20571
  24. Mijatovic Tatjana, Mathieu Véronique, Gaussin Jean-François, De Néve Nancy, Ribaucour Fabrice, Van Quaquebeke Eric, Dumont Patrick, Darro Francis, Kiss Robert, Cardenolide-Induced Lysosomal Membrane Permeabilization Demonstrates Therapeutic Benefits in Experimental Human Non-Small Cell Lung Cancers, 10.1593/neo.05850
  25. Branle Fabrice, Lefranc Florence, Camby Isabelle, Jeuken Judith, Geurts-Moespot Anneke, Sprenger Sandra, Sweep Fred, Kiss Robert, Salmon Isabelle, Evaluation of the efficiency of chemotherapy in in vivo orthotopic models of human glioma cells with and without 1p19q deletions and in C6 rat orthotopic allografts serving for the evaluation of surgery combined with chemotherapy, 10.1002/cncr.10710
  26. Van Goietsenoven G., Hutton J., Becker J.-P., Lallemand B., Robert F., Lefranc F., Pirker C., Vandenbussche G., Van Antwerpen P., Evidente A., Berger W., Prevost M., Pelletier J., Kiss R., Goss Kinzy T., Kornienko A., Mathieu V., Targeting of eEF1A with Amaryllidaceae isocarbostyrils as a strategy to combat melanomas, 10.1096/fj.10-162263
  27. Le Mercier Marie, Lefranc Florence, Mijatovic Tatjana, Debeir Olivier, Haibe-Kains Benjamin, Bontempi Gianluca, Decaestecker Christine, Kiss Robert, Mathieu Véronique, Evidence of galectin-1 involvement in glioma chemoresistance☆, 10.1016/j.taap.2008.01.009
  28. Dumont Patrick, Ingrassia Laurent, Rouzeau Sébastien, Ribaucour Fabrice, Thomas Stéphanie, Roland Isabelle, Darro Francis, Lefranc Florence, Kiss Robert, The Amaryllidaceae Isocarbostyril Narciclasine Induces Apoptosis By Activation of the Death Receptor and/or Mitochondrial Pathways in Cancer Cells But Not in Normal Fibroblasts, 10.1593/neo.07535
  29. Szakács Gergely, Annereau Jean-Philippe, Lababidi Samir, Shankavaram Uma, Arciello Angela, Bussey Kimberly J., Reinhold William, Guo Yanping, Kruh Gary D., Reimers Mark, Weinstein John N., Gottesman Michael M., Predicting drug sensitivity and resistance, 10.1016/j.ccr.2004.06.026
  30. Orina J. N., Calcagno A. M., Wu C.-P., Varma S., Shih J., Lin M., Eichler G., Weinstein J. N., Pommier Y., Ambudkar S. V., Gottesman M. M., Gillet J.-P., Evaluation of current methods used to analyze the expression profiles of ATP-binding cassette transporters yields an improved drug-discovery database, 10.1158/1535-7163.mct-09-0256
  31. Frese Steffen, Frese-Schaper Manuela, Andres Anne-Catherine, Miescher Daniela, Zumkehr Beatrice, Schmid Ralph A., Cardiac Glycosides Initiate Apo2L/TRAIL-Induced Apoptosis in Non–Small Cell Lung Cancer Cells by Up-regulation of Death Receptors 4 and 5, 10.1158/0008-5472.can-05-3544
  32. Simpson C. D., Mawji I. A., Anyiwe K., Williams M. A., Wang X., Venugopal A. L., Gronda M., Hurren R., Cheng S., Serra S., Zavareh R. B., Datti A., Wrana J. L., Ezzat S., Schimmer A. D., Inhibition of the Sodium Potassium Adenosine Triphosphatase Pump Sensitizes Cancer Cells to Anoikis and Prevents Distant Tumor Formation, 10.1158/0008-5472.can-08-2530
  33. Dong Yinhui, Yin Shutao, Li Jinghua, Jiang Cheng, Ye Min, Hu Hongbo, Bufadienolide compounds sensitize human breast cancer cells to TRAIL-induced apoptosis via inhibition of STAT3/Mcl-1 pathway, 10.1007/s10495-011-0573-5
  34. Daniel Dinara, Süsal Caner, Kopp Brigitte, Opelz Gerhard, Terness Peter, Apoptosis-mediated selective killing of malignant cells by cardiac steroids: maintenance of cytotoxicity and loss of cardiac activity of chemically modified derivatives, 10.1016/j.intimp.2003.08.004
  35. Juncker Tom, Cerella Claudia, Teiten Marie-Hélène, Morceau Franck, Schumacher Marc, Ghelfi Jenny, Gaascht François, Schnekenburger Michael, Henry Estelle, Dicato Mario, Diederich Marc, UNBS1450, a steroid cardiac glycoside inducing apoptotic cell death in human leukemia cells, 10.1016/j.bcp.2010.08.025
  36. Wang Z., Zheng M., Li Z., Li R., Jia L., Xiong X., Southall N., Wang S., Xia M., Austin C. P., Zheng W., Xie Z., Sun Y., Cardiac Glycosides Inhibit p53 Synthesis by a Mechanism Relieved by Src or MAPK Inhibition, 10.1158/0008-5472.can-09-0891
  37. Zhang H., Qian D. Z., Tan Y. S., Lee K., Gao P., Ren Y. R., Rey S., Hammers H., Chang D., Pili R., Dang C. V., Liu J. O., Semenza G. L., Digoxin and other cardiac glycosides inhibit HIF-1  synthesis and block tumor growth, 10.1073/pnas.0809763105
  38. Newman Robert A., Kondo Yasuko, Yokoyama Tomohisa, Dixon Susan, Cartwright Carrie, Chan Diana, Johansen Mary, Peiying Yang, Autophagic Cell Death of Human Pancreatic Tumor Cells Mediated by Oleandrin, a Lipid-Soluble Cardiac Glycoside, 10.1177/1534735407309623
  39. Mijatovic Tatjana, Jungwirth Ute, Heffeter Petra, Hoda Mir Ali Reza, Dornetshuber Rita, Kiss Robert, Berger Walter, The Na+/K+-ATPase is the Achilles Heel of multi-drug-resistant cancer cells, 10.1016/j.canlet.2009.02.048
  40. Langenhan J. M., Peters N. R., Guzei I. A., Hoffmann F. M., Thorson J. S., Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization, 10.1073/pnas.0503270102
  41. Tian Jiang, Li Xin, Liang Man, Liu Lijun, Xie Joe X., Ye Qiqi, Kometiani Peter, Tillekeratne Manoranjani, Jin Runming, Xie Zijian, Changes in Sodium Pump Expression Dictate the Effects of Ouabain on Cell Growth, 10.1074/jbc.m808355200
  42. Fullerton Dwight S., Kihara Masaru, Deffo Tamboue, Kitatsuji Eitaro, Ahmed Khalil, Simat Bruce, From Arthur H. L., Cardiac glycosides. 1. A systematic study of digitoxigenin D-glycosides, 10.1021/jm00369a004
  43. Rathore Hargovind, From Arthur H. L., Ahmed Khalil, Fullerton Dwight S., Cardiac glycosides. 7. Sugar stereochemistry and cardiac glycoside activity, 10.1021/jm00160a025
  44. Hashimoto Toshihiro, Rathore Hargovind, Satoh Daisuke, Griffin Jane F., From Arthur H. L., Ahmed Khalil, Fullerton Dwight S., Hong George, Cardiac glycosides. 6. Gitoxigenin C16 acetates, formates, methoxycarbonates, and digitoxosides. Synthesis and Na+,K+-ATPase inhibitory activities, 10.1021/jm00156a017
  45. Gao Huimin, Popescu Ruxandra, Kopp Brigitte, Wang Zhimin, Bufadienolides and their antitumor activity, 10.1039/c0np00032a
  46. Liu Ting, Brown David A., O'Rourke Brian, Role of mitochondrial dysfunction in cardiac glycoside toxicity, 10.1016/j.yjmcc.2010.06.012
  47. Bers Donald M., Digitalis and Na/Ca exchange: Old dog learns new mitochondrial tricks, 10.1016/j.yjmcc.2010.08.004
  48. Levin D., Harari D., Schreiber G., Stochastic Receptor Expression Determines Cell Fate upon Interferon Treatment, 10.1128/mcb.05251-11