User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Immunoglobulin heavy chain/light chain pair measurement is associated with survival in diffuse large B-cell lymphoma.

Primary tabs

Jardin, Fabrice Delfau-Larue, Marie Hélène Molina, Thierry Jo Copie-Bergman, Christiane Brière, Josette Bosly, André [UCL] André, Marc [UCL] Tilly, Hervé

Abstract Elevated serum free light chains (FLCs) have been associated with an unfavorable prognosis in diffuse large B-cell lymphoma (DLBCL). The aim of this study was to determine the clinical relevance of a quantitative assessment of intact circulating immunoglobulin (Ig), using serum Ig heavy chain/light chain pair (HLC) measurements in patients with DLBCL. FLC and HLC were measured in 409 serum samples of patients with DLBCL included in the LNH03-B clinical trial program of the Groupe d'Etudes des Lymphomes de l'Adulte (GELA). Patients with an abnormal IgMκ/IgMλ ratio or an abnormal FLC ratio more frequently displayed adverse clinical characteristics. Patients with abnormal IgMκ/IgMλ ratios had inferior progression-free survival (PFS) and overall survival (OS) as compared to patients with a normal ratio in the overall cohort (5-year PFS 44.9% vs. 69.3%, p = 0.0003 and 5-year OS 50.8% vs. 78.1%, p = 0.0003) and in the R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone) cohort (5-year OS 43.5% vs. 70.3%, p = 0.003). In multivariate analysis, including elevated FLC/HLC and International Prognostic Index (IPI), an abnormal IgMκ/IgMλ ratio (hazard ratio [HR] = 1.54, 95% confidence interval [CI] 1.03-2.3, p = 0.03) remained predictive of shorter progression-free survival. Gene expression profile experiments and immunohistochemistry indicate that this measurement is at least partially related to tumor cell secretion. Both elevated serum FLCs and an abnormal IgMκ/IgMλ ratio are associated with unfavorable outcomes in patients with DLBCL treated by R-CHOP.

Document type Article de périodique (Journal article) – Article de recherche
Publication date 2013
Language Anglais
Journal information "Leukemia and Lymphoma" - Vol. 54, no.9, p. 1898-1907 (2013)
Peer reviewed yes
Publisher Informa Healthcare ((United Kingdom) London)
issn 1042-8194
e-issn 1029-2403
Publication status Publié
Affiliations UCL - (MGD) Service d'hématologie
UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie
Links
  1. Maurer M. J., Cerhan J. R., Katzmann J. A., Link B. K., Allmer C., Zent C. S., Call T. G., Rabe K. G., Hanson C. A., Kay N. E., Slager S. L., Witzig T. E., Shanafelt T. D., Monoclonal and polyclonal serum free light chains and clinical outcome in chronic lymphocytic leukemia, 10.1182/blood-2011-04-349134
  2. Drake Matthew T., Maurer Matthew J., Link Brian K., Habermann Thomas M., Ansell Stephen M., Micallef Ivana N., Kelly Jennifer L., Macon William R., Nowakowski Grzegorz S., Inwards David J., Johnston Patrick B., Singh Ravinder J., Allmer Cristine, Slager Susan L., Weiner George J., Witzig Thomas E., Cerhan James R., Vitamin D Insufficiency and Prognosis in Non-Hodgkin's Lymphoma, 10.1200/jco.2010.28.6674
  3. Last Kim W., Cornelius Victoria, Delves Trevor, Sieniawska Christine, Fitzgibbon Jude, Norton Andrew, Amess John, Wilson Andy, Rohatiner Ama Z.S., Lister T. Andrew, Presentation Serum Selenium Predicts for Overall Survival, Dose Delivery, and First Treatment Response in Aggressive Non-Hodgkin’s Lymphoma, 10.1200/jco.2003.06.145
  4. Lawrie Charles H., Gal Shira, Dunlop Heather M., Pushkaran Beena, Liggins Amanda P., Pulford Karen, Banham Alison H., Pezzella Francesco, Boultwood Jacqueline, Wainscoat James S., Hatton Christian S. R., Harris Adrian L., Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma, 10.1111/j.1365-2141.2008.07077.x
  5. Lech-Maranda E, Eur Cytokine Netw, 17, 60 (2006)
  6. López-Guillermo Armando, Colomo Luis, Jiménez Mónica, Bosch Francesc, Villamor Neus, Arenillas Leonor, Muntañola Ana, Montoto Silvia, Giné Eva, Colomer Dolors, Beà Silvia, Campo Elías, Montserrat Emili, Diffuse Large B-Cell Lymphoma: Clinical and Biological Characterization and Outcome According to the Nodal or Extranodal Primary Origin, 10.1200/jco.2005.07.155
  7. Niitsu N, Okamoto M, Okabe-Kado J, Takagi T, Yoshida T, Aoki S, Honma Y, Hirano M, Serum nm23-H1 protein as a prognostic factor for indolent non-Hodgkin’s lymphoma, 10.1038/sj.leu.2402105
  8. Goto Naoe, Tsurumi Hisashi, Kasahara Senji, Kanemura Nobuhiro, Hara Takeshi, Yasuda Ichiro, Shimizu Masahito, Murakami Nobuo, Sawada Michio, Yamada Toshiki, Takemura Masao, Seishima Mitsuru, Kito Yusuke, Takami Tsuyoshi, Moriwaki Hisataka, Serum interleukin-18 level is associated with the outcome of patients with diffuse large B-cell lymphoma treated with CHOP or R-CHOP regimens : Serum IL-18 for DLBCL, 10.1111/j.1600-0609.2011.01649.x
  9. Bono Petri, Teerenhovi Lasse, Joensuu Heikki, Elevated serum endostatin is associated with poor outcome in patients with non-Hodgkin lymphoma, 10.1002/cncr.11399
  10. Giachelia Manuela, Voso Maria Teresa, Tisi Maria Chiara, Martini Maurizio, Bozzoli Valentina, Massini Giuseppina, D'Aló Francesco, Larocca Luigi Maria, Leone Giuseppe, Hohaus Stefan, Interleukin-6 plasma levels are modulated by a polymorphism in theNF-κB1gene and are associated with outcome following rituximab-combined chemotherapy in diffuse large B-cell non-Hodgkin lymphoma, 10.3109/10428194.2011.621566
  11. Wang Liang, Liu Panpan, Chen Xiaoqin, Geng Qirong, Lu Yue, Serum neuron-specific enolase is correlated with clinical outcome of patients with non-germinal center B cell-like subtype of diffuse large B-cell lymphoma treated with rituximab-based immunochemotherapy, 10.1007/s12032-011-0049-z
  12. Martin William, Abraham Roshini, Shanafelt Tait, Clark Raynell J., Bone Nancy, Geyer Susan M., Katzmann Jerry A., Bradwell Arthur, Kay Neil E., Witzig Thomas E., Serum-free light chain—a new biomarker for patients with B-cell non-Hodgkin lymphoma and chronic lymphocytic leukemia, 10.1016/j.trsl.2006.11.001
  13. Charafeddine Khalil M., Jabbour Mark N., Kadi Raneem H., Daher Rose T., Extended Use of Serum Free Light Chain as a Biomarker in Lymphoproliferative Disorders : A Comprehensive Review, 10.1309/ajcp4inkz6lyaqxw
  14. Maurer Matthew J., Micallef Ivana N.M., Cerhan James R., Katzmann Jerry A., Link Brian K., Colgan Joseph P., Habermann Thomas M., Inwards David J., Markovic Svetomir N., Ansell Stephen M., Porrata Luis F., Johnston Patrick B., Nowakowski Grzegorz S., Thompson Carrie A., Gupta Mamta, Syrbu Sergei I., Kurtin Paul J., Macon William R., Nikcevich Daniel A., Witzig Thomas E., Elevated Serum Free Light Chains Are Associated With Event-Free and Overall Survival in Two Independent Cohorts of Patients With Diffuse Large B-Cell Lymphoma, 10.1200/jco.2010.29.4413
  15. Furtado Michelle, Shah Nimish, Levoguer Alison, Harding Stephen, Rule Simon, Abnormal serum free light chain ratio predicts poor overall survival in mantle cell lymphoma, 10.1111/bjh.12094
  16. Thompson Carrie A., Maurer Matthew J., Cerhan James R., Katzmann Jerry A., Ansell Stephen M., Habermann Thomas M., Macon William R., Weiner George J., Link Brian K., Witzig Thomas E., Elevated serum free light chains are associated with inferior event free and overall survival in Hodgkin lymphoma, 10.1002/ajh.22168
  17. Bradwell A. R., Harding S. J., Fourrier N. J., Wallis G. L.F., Drayson M. T., Carr-Smith H. D., Mead G. P., Assessment of Monoclonal Gammopathies by Nephelometric Measurement of Individual Immunoglobulin  /  Ratios, 10.1373/clinchem.2009.123828
  18. Leleu Xavier, Koulieris Efstathios, Maltezas Dimitrios, Itzykson Raphael, Xie Wanling, Manier Salomon, Dulery Remy, Boyle Eilleen, Gauthier Jordan, Poulain Stéphanie, Tatiana Tzenou, Panayiotidis Panayiotis, Bradwell Arthur R., Harding Stephen, Leblond Veronique, Kyrtsonis Marie-Christine, Ghobrial Irene M., Novel M-Component Based Biomarkers in Waldenström's Macroglobulinemia, 10.3816/clml.2011.n.039
  19. Avet-Loiseau H, Blood, 114, 1818 (2009)
  20. Récher Christian, Coiffier Bertrand, Haioun Corinne, Molina Thierry Jo, Fermé Christophe, Casasnovas Olivier, Thiéblemont Catherine, Bosly André, Laurent Guy, Morschhauser Franck, Ghesquières Hervé, Jardin Fabrice, Bologna Serge, Fruchart Christophe, Corront Bernadette, Gabarre Jean, Bonnet Christophe, Janvier Maud, Canioni Danielle, Jais Jean-Philippe, Salles Gilles, Tilly Hervé, Intensified chemotherapy with ACVBP plus rituximab versus standard CHOP plus rituximab for the treatment of diffuse large B-cell lymphoma (LNH03-2B): an open-label randomised phase 3 trial, 10.1016/s0140-6736(11)61040-4
  21. Peyrade Frédéric, Jardin Fabrice, Thieblemont Catherine, Thyss Antoine, Emile Jean-François, Castaigne Sylvie, Coiffier Bertrand, Haioun Corinne, Bologna Serge, Fitoussi Olivier, Lepeu Gérard, Fruchart Christophe, Bordessoule Dominique, Blanc Michel, Delarue Richard, Janvier Maud, Salles Bruno, André Marc, Fournier Marion, Gaulard Philippe, Tilly Hervé, Attenuated immunochemotherapy regimen (R-miniCHOP) in elderly patients older than 80 years with diffuse large B-cell lymphoma: a multicentre, single-arm, phase 2 trial, 10.1016/s1470-2045(11)70069-9
  22. Fitoussi O., Belhadj K., Mounier N., Parrens M., Tilly H., Salles G., Feugier P., Ferme C., Ysebaert L., Gabarre J., Herbrecht R., Janvier M., Van Den Neste E., Morschhauser F., Casasnovas O., Ghesquieres H., Anglaret B., Brechignac S., Haioun C., Gisselbrecht C., Survival impact of rituximab combined with ACVBP and upfront consolidation autotransplantation in high-risk diffuse large B-cell lymphoma for GELA, 10.3324/haematol.2010.038109
  23. Delarue R, Blood, 114, 406 (2009)
  24. Jais J-P, Haioun C, Molina T J, Rickman D S, de Reynies A, Berger F, Gisselbrecht C, Brière J, Reyes F, Gaulard P, Feugier P, Labouyrie E, Tilly H, Bastard C, Coiffier B, Salles G, Leroy K, The expression of 16 genes related to the cell of origin and immune response predicts survival in elderly patients with diffuse large B-cell lymphoma treated with CHOP and rituximab, 10.1038/leu.2008.188
  25. Wright G., Tan B., Rosenwald A., Hurt E. H., Wiestner A., Staudt L. M., A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma, 10.1073/pnas.1732008100
  26. Hutchison Colin A, Cockwell Paul, Harding Steven, Mead Graham P, Bradwell Arthur R, Barnett Anthony H, Quantitative assessment of serum and urinary polyclonal free light chains in patients with type II diabetes: an early marker of diabetic kidney disease?, 10.1517/14728222.12.6.667
  27. Brunello Antonella, Kapoor Rachna, Extermann Martine, Hyperglycemia During Chemotherapy for Hematologic and Solid Tumors Is Correlated With Increased Toxicity : , 10.1097/coc.0b013e3181e1d0c0
  28. Zimmermann Heiner, Oschlies Ilske, Fink Susanne, Pott Christiane, Neumayer Hans H., Lehmkuhl Hans, Hauser Ingeborg A., Dreyling Martin, Kneba Michael, Gärtner Barbara, Anagnostopoulos Ioannis, Riess Hanno, Klapper Wolfram, Trappe Ralf U., Plasmablastic Posttransplant Lymphoma : Cytogenetic Aberrations and Lack of Epstein-Barr Virus Association Linked With Poor Outcome in the Prospective German Posttransplant Lymphoproliferative Disorder Registry, 10.1097/tp.0b013e318242162d
  29. Shin Ho-Jin, Chung Joo Seop, Song Moo-Kon, Kim Seon-Kyeong, Choe Sangmin, Cho Goon-Jae, Addition of rituximab to reduced-dose CHOP chemotherapy is feasible for elderly patients with diffuse large B-cell lymphoma, 10.1007/s00280-011-1814-6
  30. Ruminy P, Etancelin P, Couronné L, Parmentier F, Rainville V, Mareschal S, Bohers E, Burgot C, Cornic M, Bertrand P, Lenormand B, Picquenot J-M, Jardin F, Tilly H, Bastard C, The isotype of the BCR as a surrogate for the GCB and ABC molecular subtypes in diffuse large B-cell lymphoma, 10.1038/leu.2010.302
  31. Schroers Roland, Baraniskin Alexander, Heute Christoph, Kuhnhenn Jan, Alekseyev Andriy, Schmiegel Wolff, Schlegel Uwe, Pels Hendrik-Johannes, Detection of free immunoglobulin light chains in cerebrospinal fluids of patients with central nervous system lymphomas : Free light chains in CSF of CNS lymphomas, 10.1111/j.1600-0609.2010.01475.x
  32. Klapper W., Kreuz M., Kohler C. W., Burkhardt B., Szczepanowski M., Salaverria I., Hummel M., Loeffler M., Pellissery S., Woessmann W., Schwanen C., Trumper L., Wessendorf S., Spang R., Hasenclever D., Siebert R., , Patient age at diagnosis is associated with the molecular characteristics of diffuse large B-cell lymphoma, 10.1182/blood-2011-10-388470
  33. Mareschal S., Lanic H., Ruminy P., Bastard C., Tilly H., Jardin F., The proportion of activated B-cell like subtype among de novo diffuse large B-cell lymphoma increases with age, 10.3324/haematol.2011.050617
Bibliographic reference Jardin, Fabrice ; Delfau-Larue, Marie Hélène ; Molina, Thierry Jo ; Copie-Bergman, Christiane ; Brière, Josette ; et. al. Immunoglobulin heavy chain/light chain pair measurement is associated with survival in diffuse large B-cell lymphoma.. In: Leukemia and Lymphoma, Vol. 54, no.9, p. 1898-1907 (2013)
Permanent URL http://hdl.handle.net/2078.1/133818