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Evasion of Antiviral Innate Immunity by Theiler's Virus L* Protein through Direct Inhibition of RNase L.

Bibliographic reference Sorgeloos, Frédéric ; Jha, Babal Kant ; Silverman, Robert H ; Michiels, Thomas. Evasion of Antiviral Innate Immunity by Theiler's Virus L* Protein through Direct Inhibition of RNase L.. In: PLoS Pathogens, Vol. 9, no.6, p. e1003474 (2013)
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  1. Bisbal Catherine, Silverman Robert H., Diverse functions of RNase L and implications in pathology, 10.1016/j.biochi.2007.02.006
  2. Weber F., Wagner V., Rasmussen S. B., Hartmann R., Paludan S. R., Double-Stranded RNA Is Produced by Positive-Strand RNA Viruses and DNA Viruses but Not in Detectable Amounts by Negative-Strand RNA Viruses, 10.1128/jvi.80.10.5059-5064.2006
  3. Kerr I. M., Brown R. E., pppA2'p5'A2'p5'A: an inhibitor of protein synthesis synthesized with an enzyme fraction from interferon-treated cells., 10.1073/pnas.75.1.256
  4. Dong Beihua, Silverman Robert H., 2-5A-dependent RNase Molecules Dimerize during Activation by 2-5A, 10.1074/jbc.270.8.4133
  5. Dong Beihua, Silverman Robert H., A Bipartite Model of 2-5A-dependent RNase L, 10.1074/jbc.272.35.22236
  6. Han Yuchen, Whitney Gena, Donovan Jesse, Korennykh Alexei, Innate Immune Messenger 2-5A Tethers Human RNase L into Active High-Order Complexes, 10.1016/j.celrep.2012.09.004
  7. Malathi Krishnamurthy, Dong Beihua, Gale Michael, Silverman Robert H., Small self-RNA generated by RNase L amplifies antiviral innate immunity, 10.1038/nature06042
  8. Zhou A, Expression cloning of 2-5A-dependent RNAase: A uniquely regulated mediator of interferon action, 10.1016/0092-8674(93)90403-d
  9. Austin B. A., James C., Silverman R. H., Carr D. J. J., Critical Role for the Oligoadenylate Synthetase/RNase L Pathway in Response to IFN-  during Acute Ocular Herpes Simplex Virus Type 1 Infection, 10.4049/jimmunol.175.2.1100
  10. X Zheng, Invest Ophthalmol Vis Sci, 42, 120 (2001)
  11. Díaz-Guerra Margarita, Rivas Carmen, Esteban Mariano, Activation of the IFN-Inducible Enzyme RNase L Causes Apoptosis of Animal Cells, 10.1006/viro.1997.8719
  12. Flodstrom-Tullberg M., Hultcrantz M., Stotland A., Maday A., Tsai D., Fine C., Williams B., Silverman R., Sarvetnick N., RNase L and Double-Stranded RNA-Dependent Protein Kinase Exert Complementary Roles in Islet Cell Defense during Coxsackievirus Infection, 10.4049/jimmunol.174.3.1171
  13. Samuel M. A., Whitby K., Keller B. C., Marri A., Barchet W., Williams B. R. G., Silverman R. H., Gale M., Diamond M. S., PKR and RNase L Contribute to Protection against Lethal West Nile Virus Infection by Controlling Early Viral Spread in the Periphery and Replication in Neurons, 10.1128/jvi.00489-06
  14. Cruz Jazmina L. G., Sola Isabel, Becares Martina, Alberca Berta, Plana Joan, Enjuanes Luis, Zuñiga Sonia, Coronavirus Gene 7 Counteracts Host Defenses and Modulates Virus Virulence, 10.1371/journal.ppat.1002090
  15. Zhao Ling, Jha Babal K., Wu Ashley, Elliott Ruth, Ziebuhr John, Gorbalenya Alexander E., Silverman Robert H., Weiss Susan R., Antagonism of the Interferon-Induced OAS-RNase L Pathway by Murine Coronavirus ns2 Protein Is Required for Virus Replication and Liver Pathology, 10.1016/j.chom.2012.04.011
  16. HAN JIAN-QIU, BARTON DAVID J., Activation and evasion of the antiviral 2???-5??? oligoadenylate synthetase/ribonuclease L pathway by hepatitis C virus mRNA, 10.1017/s1355838202020617
  17. Han Jian-Qiu, Wroblewski Greggory, Xu Zan, Silverman Robert H., Barton David J., Sensitivity of Hepatitis C Virus RNA to the Antiviral Enzyme Ribonuclease L Is Determined by a Subset of Efficient Cleavage Sites, 10.1089/jir.2004.24.664
  18. Han J.-Q., Townsend H. L., Jha B. K., Paranjape J. M., Silverman R. H., Barton D. J., A Phylogenetically Conserved RNA Structure in the Poliovirus Open Reading Frame Inhibits the Antiviral Endoribonuclease RNase L, 10.1128/jvi.01857-06
  19. Townsend H. L., Jha B. K., Han J.-Q., Maluf N. K., Silverman R. H., Barton D. J., A viral RNA competitively inhibits the antiviral endoribonuclease domain of RNase L, 10.1261/rna.958908
  20. Martinand Camille, Salehzada Tamim, Silhol Michelle, Lebleu Bernard, Bisbal Catherine, RNase L inhibitor (RLI) antisense constructions block partially the down regulation of the 2-5A/RNase L pathway in encephalomyocarditis-virus-(EMCV)-infected cells, 10.1046/j.1432-1327.1998.2540248.x
  21. CAYLEY P. Jane, DAVIES John A., McCULLAGH Keith G., KERR Ian M., Activation of the ppp(A2'p)nA system in interferon-treated, Herpes simplex virus-infected cells and evidence for novel inhibitors of the ppp(A2'p)nA-dependent RNase, 10.1111/j.1432-1033.1984.tb08355.x
  22. CL Hersh, J Biol Chem, 259, 1731 (1984)
  23. AP Rice, J Virol, 56, 1041 (1985)
  24. AP Rice, J Virol, 50, 220 (1984)
  25. Carpten J., Nupponen N., Isaacs S., Sood R., Robbins C., Xu J., Faruque M., Moses T., Ewing C., Gillanders E., Hu P., Bujnovszky P., Makalowska I., Baffoe-Bonnie A., Faith D., Smith J., Stephan D., Wiley K., Brownstein M., Gildea D., Kelly B., Jenkins R., Hostetter G., Matikainen M., Schleutker J., Klinger K., Connors T., Xiang Y., Wang Z., De Marzo A., Papadopoulos N., Kallioniemi O.-P., Burk R., Meyers D., Grönberg H., Meltzer P., Silverman R., Bailey-Wilson J., Walsh P., Isaacs W., Trent J., Germline mutations in the ribonuclease L gene in families showing linkage with HPC1, 10.1038/ng823
  26. Madsen Bo Eskerod, Ramos Eliana Marisa, Boulard Mathieu, Duda Katarzyna, Overgaard Jens, Nordsmark Marianne, Wiuf Carsten, Hansen Lise Lotte, Germline Mutation in RNASEL Predicts Increased Risk of Head and Neck, Uterine Cervix and Breast Cancer, 10.1371/journal.pone.0002492
  28. HL Lipton, J Virol, 69, 2525 (1995)
  29. Roussarie Jean-Pierre, Ruffié Claude, Brahic Michel, The Role of Myelin in Theiler's Virus Persistence in the Central Nervous System, 10.1371/journal.ppat.0030023
  30. Michiels T, Roos R (2010) Theiler's Virus Central Nervous System Infection. In: Ehrenfeld E, Domingo E, Roos R, editors. The Picornaviruses. Washington: American Society for Microbiology. pp. 411–428.
  31. Oleszak E. L., Chang J. R., Friedman H., Katsetos C. D., Platsoucas C. D., Theiler's Virus Infection: a Model for Multiple Sclerosis, 10.1128/cmr.17.1.174-207.2004
  32. GD Ghadge, J Virol, 72, 8605 (1998)
  33. WP Kong, J Virol, 65, 3395 (1991)
  34. van Eyll O., Michiels T., Non-AUG-Initiated Internal Translation of the L* Protein of Theiler's Virus and Importance of This Protein for Viral Persistence, 10.1128/jvi.76.21.10665-10673.2002
  35. H Takata, J Virol, 72, 4950 (1998)
  36. van Eyll O., Michiels T., Influence of the Theiler's Virus L* Protein on Macrophage Infection, Viral Persistence, and Neurovirulence, 10.1128/jvi.74.19.9071-9077.2000
  37. Obuchi Masatsugu, Yamamoto Jiro, Uddin Md. Nasir, Odagiri Takato, Iizuka Hideaki, Ohara Yoshiro, Theiler's Murine Encephalomyelitis Virus (TMEV) Subgroup Strain-Specific Infection in Neural and Non-Neural Cell Lines, 10.1111/j.1348-0421.1999.tb01223.x
  38. Himeda Toshiki, Ohara Yoshiro, Asakura Kunihiko, Kontani Yasuhide, Sawada Makoto, A lentiviral expression system demonstrates that L* protein of Theiler's murine encephalomyelitis virus (TMEV) has an anti-apoptotic effect in a macrophage cell line, 10.1016/j.micpath.2005.01.005
  39. Sorgeloos F., Vertommen D., Rider M. H., Michiels T., Theiler's Virus L* Protein Is Targeted to the Mitochondrial Outer Membrane, 10.1128/jvi.02023-10
  40. Silverman R. H., Viral Encounters with 2',5'-Oligoadenylate Synthetase and RNase L during the Interferon Antiviral Response, 10.1128/jvi.01471-07
  41. Zhou Aimin, Molinaro Ross J., Malathi Krishnamurthy, Silverman Robert H., Mapping of the HumanRNASELPromoter and Expression in Cancer and Normal Cells, 10.1089/jir.2005.25.595
  42. Jnaoui Karima, Michiels Thomas, Adaptation of Theiler's Virus to L929 Cells: Mutations in the Putative Receptor Binding Site on the Capsid Map to Neutralization Sites and Modulate Viral Persistence, 10.1006/viro.1998.9134
  43. Thakur C. S., Jha B. K., Dong B., Das Gupta J., Silverman K. M., Mao H., Sawai H., Nakamura A. O., Banerjee A. K., Gudkov A., Silverman R. H., Small-molecule activators of RNase L with broad-spectrum antiviral activity, 10.1073/pnas.0700590104
  44. Himeda Toshiki, Okuwa Takako, Nojiri Masafumi, Muraki Yasushi, Ohara Yoshiro, The anti-apoptotic protein L* of Theiler's murine encephalomyelitis virus (TMEV) contains a mitochondrial targeting signal, 10.1016/j.virusres.2010.11.006
  45. Obuchi M., Yamamoto J., Odagiri T., Uddin M. N., Iizuka H., Ohara Y., L* Protein of Theiler's Murine Encephalomyelitis Virus Is Required for Virus Growth in a Murine Macrophage-Like Cell Line, 10.1128/jvi.74.10.4898-4901.2000
  46. Zhou A., Interferon action and apoptosis are defective in mice devoid of 2',5'-oligoadenylate-dependent RNase L, 10.1093/emboj/16.21.6355
  47. Azoulay-Cayla A., Dethlefs S., Perarnau B., Larsson-Sciard E.-L., Lemonnier F. A., Brahic M., Bureau J.-F., H-2Db-/- Mice Are Susceptible to Persistent Infection by Theiler's Virus, 10.1128/jvi.74.12.5470-5476.2000
  48. Brahic Michel, Bureau Jean-François, Michiels Thomas, THE GENETICS OF THE PERSISTENT INFECTION AND DEMYELINATING DISEASE CAUSED BY THEILER'S VIRUS, 10.1146/annurev.micro.59.030804.121242
  49. HL Lipton, Infect Immun, 26, 369 (1979)
  50. Nakanishi Masayuki, Goto Yoshikuni, Kitade Yukio, 2-5A induces a conformational change in the ankyrin-repeat domain of RNase L, 10.1002/prot.20474
  51. Min J.-Y., Krug R. M., The primary function of RNA binding by the influenza A virus NS1 protein in infected cells: Inhibiting the 2'-5' oligo (A) synthetase/RNase L pathway, 10.1073/pnas.0602184103
  52. Chiu C. Y., Greninger A. L., Kanada K., Kwok T., Fischer K. F., Runckel C., Louie J. K., Glaser C. A., Yagi S., Schnurr D. P., Haggerty T. D., Parsonnet J., Ganem D., DeRisi J. L., Identification of cardioviruses related to Theiler's murine encephalomyelitis virus in human infections, 10.1073/pnas.0805968105
  53. Jones M. S., Lukashov V. V., Ganac R. D., Schnurr D. P., Discovery of a Novel Human Picornavirus in a Stool Sample from a Pediatric Patient Presenting with Fever of Unknown Origin, 10.1128/jcm.00174-07
  54. Zoll Jan, Erkens Hulshof Sandra, Lanke Kjerstin, Verduyn Lunel Frans, Melchers Willem J. G., Schoondermark-van de Ven Esther, Roivainen Merja, Galama Jochem M. D., van Kuppeveld Frank J. M., Saffold Virus, a Human Theiler's-Like Cardiovirus, Is Ubiquitous and Causes Infection Early in Life, 10.1371/journal.ppat.1000416
  55. van Pesch V., van Eyll O., Michiels T., The Leader Protein of Theiler's Virus Inhibits Immediate-Early Alpha/Beta Interferon Production, 10.1128/jvi.75.17.7811-7817.2001
  56. T Michiels, J Virol, 71, 9549 (1997)
  57. Naldini Luigi, Follenzi Antonia, Ailles Laurie E., Bakovic Silvia, Geuna Massimo, 10.1038/76095
  58. Chomczynski Piotr, Sacchi Nicoletta, Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction, 10.1016/0003-2697(87)90021-2
  59. Paul S., Cardiovirus leader proteins are functionally interchangeable and have evolved to adapt to virus replication fitness, 10.1099/vir.0.81642-0
  60. Rusch Lorraine, Dong Beihua, Silverman Robert H., Monitoring Activation of Ribonuclease L by 2′, 5′-Oligoadenylates Using Purified Recombinant Enzyme and Intact Malignant Glioma Cells, Methods in Enzymology (2001) ISBN:9780121822439 p.10-20, 10.1016/s0076-6879(01)42531-6
  61. B Dong, J Biol Chem, 269, 14153 (1994)