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Postnatal catch-up growth induced by growth hormone and insulin-like growth factor-I in rats with intrauterine growth retardation caused by maternal protein malnutrition

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Muaku, Séverin M. [UCL] Thissen, Jean-Paul [UCL] Gerard, Guy [UCL] Ketelslegers, Jean-Marie [UCL] Maiter, Dominique [UCL]

In this study, we examined the effects of exogenous IGF-I and GH on postnatal growth of rat pups with intrauterine growth retardation due to gestational protein restriction. From birth until weaning (d 23), pups born from dams fed ad libitum a low (5% casein; P5 pups) or a normal protein diet (20% casein; P20 controls) were cross-fostered to well nourished lactating dams. On d 2, the litters (n = 6/dietary group) were reduced in size to 6 pups, and littermates received, through postnatal d 23, two daily s.c. injections of bovine GH (2.5 microg/g of body weight (BW)/day), human IGF-I (1.8 microg/g of BW/day), or saline. At birth, BW and tail length (TL) of P5 pups were markedly decreased (to 72 and 70% of controls, respectively; p < 0.001). Despite food rehabilitation, stunting of body growth was still apparent on d 23 in the saline-injected P5 rats (BW and TL: 76 and 83% of age-matched saline-injected controls; p < 0.01). Serum IGF-I (-51%; p < 0.001) and weight of liver, heart, kidney, brain, and thymus (-13 to -35%; p < 0.01) were also reduced. Administration of GH in P5 rats raised their serum IGF-I (1-fold) to levels observed in saline-injected controls, and restored normal BW and TL (94 and 98% of controls, respectively), and organ weight (91-107% of those of controls). Injections of IGF-I in P5 rats increased after 1 h their serum IGF-I to levels 3 times greater than in saline-injected controls, and resulted in normalization of BW and TL (94 and 96% of controls), and organ weight (92-111% of controls). In P20 controls, 3-wk GH and IGF-I injections significantly increased serum IGF-I (0.6- and 2-fold increases, respectively), BW (14 and 11%), TL (12 and 11%), and organ weight (+10 to 30%) compared with saline-injected rats (p < 0.01). We conclude that under conditions of adequate nutrition, both GH and IGF-I may equally promote postnatal catch-up growth in rats with intrauterine growth retardation caused by gestational protein malnutrition.

Document type Article de périodique (Journal article) – Article de recherche – Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
Access type Accès restreint
Publication date 1997
Language Anglais
Journal information "Pediatric Research : international journal of human developmental biology" - Vol. 42, no. 3, p. 370-377 (1997)
Peer reviewed yes
Publisher Nature Publishing Group (New York)
issn 0031-3998
e-issn 1530-0447
Publication status Publié
Affiliations UCL - MD/MINT - Département de médecine interne
UCL - (SLuc) Service d'endocrinologie et de nutrition
MESH Subject Animal Feed ; Animal Nutrition Physiology ; Animals ; Animals, Newborn - growth & development ; Animals, Suckling ; Diet, Protein-Restricted ; Embryonic and Fetal Development - physiology ; Female ; Fetal Growth Retardation - etiology - physiopathology ; Gestational Age ; Growth - drug effects ; Growth Hormone - pharmacology ; Insulin-Like Growth Factor I - genetics - pharmacology ; Liver - chemistry - drug effects - growth & development ; Male ; Maternal-Fetal Exchange ; Organ Size - drug effects - physiology ; Pregnancy ; Prenatal Exposure Delayed Effects ; Protein-Energy Malnutrition - complications ; RNA, Messenger - metabolism ; Rats ; Rats, Wistar
Links
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Bibliographic reference Muaku, Séverin M. ; Thissen, Jean-Paul ; Gerard, Guy ; Ketelslegers, Jean-Marie ; Maiter, Dominique. Postnatal catch-up growth induced by growth hormone and insulin-like growth factor-I in rats with intrauterine growth retardation caused by maternal protein malnutrition. In: Pediatric Research : international journal of human developmental biology, Vol. 42, no. 3, p. 370-377 (1997)
Permanent URL http://hdl.handle.net/2078.1/13154