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Infection of macrophages by Theiler's murine encephalomyelitis virus is highly dependent on their activation or differentiation state

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Shaw-Jackson, Chloë Michiels, Thomas [UCL]

Macrophages are the main targets of Theiler's murine encephalomyelitis virus (TMEV) during persistent demyelinating infection of mice. Replication of TMEV in macrophages was previously shown to depend on their activation state. Here, we show that the quality of the serum used for culture drastically influences viral entry in RAW264.7 macrophages.

Document type Article de périodique (Journal article) – Article de recherche – Journal Article, Research Support, Non-U.S. Gov't
Access type Accès libre
Publication date 1997
Language Anglais
Journal information "Journal of Virology" - Vol. 71, no. 11, p. 8864-8867 (1997)
Peer reviewed yes
Publisher American Society for Microbiology
issn 0022-538X
e-issn 1098-5514
Publication status Publié
Affiliation UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique
MESH Subject Animals ; Cell Differentiation ; Cell Line ; Culture Media ; Cytopathogenic Effect, Viral ; Macrophage Activation ; Macrophages - cytology - virology ; Mice ; Poliomyelitis - pathology ; Theilovirus - growth & development ; Tumor Necrosis Factor-alpha - biosynthesis
Links
Bibliographic reference Shaw-Jackson, Chloë ; Michiels, Thomas. Infection of macrophages by Theiler's murine encephalomyelitis virus is highly dependent on their activation or differentiation state. In: Journal of Virology, Vol. 71, no. 11, p. 8864-8867 (1997)
Permanent URL http://hdl.handle.net/2078.1/13152