Phosphonated benzoxazole derivatives: synthesis and metal complexing properties

Lagadic, Elodie [UCL] Bruynel, Frédéric [UCL] Demeyer, Noémie [UCL] Herent, Marie-France [UCL] Garcia, Yann [UCL] Marchand-Brynaert, Jacqueline [UCL]

Phosphonated benzoxazole derivatives are good candidates as ligands for metal complexes. Two regioisomers were synthesized with the phosphonate function at the C-4 and C-7 positions. Different alkyl chains were also introduced at the C-2 position to functionalize these two regioisomers and increase their complexation properties. The formation of coordination complexes of selected benzoxazoles with M2+ and M3+ metal cations has been screened in solution using HRMS (high-resolution mass spectrometry) as the analytical tool.