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Interleukin 9-induced in vivo expansion of the B-1 lymphocyte population.

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Vink, Anne [UCL] Warnier, Guy [UCL] Brombacher, F. [University of Cape Town, 7925 Cape Town, South Africa] Renauld, Jean-Christophe [UCL]

The activity of interleukin (IL)-9 on B cells was analyzed in vivo using transgenic mice that constitutively express this cytokine. These mice show an increase in both baseline and antigen-specific immunoglobulin concentrations for all isotypes tested. Analysis of B cell populations showed a specific expansion of Mac-1(+) B-1 cells in the peritoneal and pleuropericardial cavities, and in the blood of IL-9 transgenic mice. In normal mice, the IL-9 receptor was found to be expressed by CD5(+) as well as CD5(-) B-1 cells, and repeated injections of IL-9 resulted in accumulation of B-1 cells in the peritoneal cavity, as observed in transgenic animals. Unlike other mouse models, such as IL-5 transgenic mice, in which expansion of the B-1 population is associated with high levels of autoantibodies, IL-9 did not stimulate the production of autoantibodies in vivo, and most of the expanded cells were found to belong to the B-1b subset (IgM+Mac-1(+)CD5(-)). In addition, we found that these IL-9-expanded B-1b cells do not share the well-documented antibromelain-treated red blood cell specificity of CD5(+) B-1a cells. The increase of antigen-specific antibody concentration in immunized mice suggests that these B-1 cells are directly or indirectly involved in antibody responses in IL-9 transgenic mice.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 1999
Journal information "The Journal of experimental medicine" - Vol. 189, no. 9, p. 1413-23 (1999)
Peer reviewed yes
issn 0022-1007
Publication status Publié
Affiliation UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique
MESH Subject Animals ; B-Lymphocytes - cytology - metabolism ; Cell Count ; Female ; Immunoglobulins - biosynthesis ; Interleukin-5 - metabolism ; Interleukin-9 - genetics - metabolism ; Lymphoid Tissue - cytology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Peritoneum - cytology ; Receptors, Interleukin - biosynthesis ; Receptors, Interleukin-9
Keywords Cytokines ; Transgenic mice ; B-1 lymphocytes ; Autoimmunity
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Bibliographic reference Vink, Anne ; Warnier, Guy ; Brombacher, F. ; Renauld, Jean-Christophe. Interleukin 9-induced in vivo expansion of the B-1 lymphocyte population.. In: The Journal of experimental medicine, Vol. 189, no. 9, p. 1413-23 (1999)
Permanent URL http://hdl.handle.net/2078.1/13031