User menu

Cytosolic NADPH homeostasis in glucose-starved procyclic Trypanosoma brucei relies on malic enzyme and the pentose phosphate pathway fed by gluconeogenic flux.

Bibliographic reference Allmann, Stefan ; Morand, Pauline ; Ebikeme, Charles ; Gales, Lara ; Biran, Marc ; et. al. Cytosolic NADPH homeostasis in glucose-starved procyclic Trypanosoma brucei relies on malic enzyme and the pentose phosphate pathway fed by gluconeogenic flux.. In: Journal of Biological Chemistry, Vol. 288, no. 25, p. 18494-18505 (2013)
Permanent URL
  1. Hao Zhengrong, Kasumba Irene, Aksoy Serap, Proventriculus (cardia) plays a crucial role in immunity in tsetse fly (Diptera: Glossinidiae), 10.1016/j.ibmb.2003.07.001
  2. Fairlamb A., Blackburn P, Ulrich P, Chait B., Cerami A, Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids, 10.1126/science.3883489
  3. Arrick B. A., Inhibition of glutathione synthesis as a chemotherapeutic strategy for trypanosomiasis, 10.1084/jem.153.3.720
  4. Krieger S., Schwarz W., Ariyanayagam M. R., Fairlamb A. H., Krauth-Siegel R. L., Clayton C., Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress : Trypanosomes lacking trypanothione reductase, 10.1046/j.1365-2958.2000.01721.x
  5. Huynh Tu T., Huynh Van T., Harmon Margaret A., Phillips Margaret A., Gene Knockdown of γ-Glutamylcysteine Synthetase by RNAiin the Parasitic ProtozoaTrypanosoma bruceiDemonstrates That It Is an Essential Enzyme, 10.1074/jbc.m306306200
  6. Comini Marcelo A., Krauth-Siegel R. Luise, Flohé Leopold, Depletion of the thioredoxin homologue tryparedoxin impairs antioxidative defence in African trypanosomes, 10.1042/bj20061341
  7. BARRETT M, The pentose phosphate pathway and parasitic protozoa, 10.1016/s0169-4758(96)10075-2
  8. Heise Norton, Opperdoes Fred R., Purification, localisation and characterisation of glucose-6-phosphate dehydrogenase of Trypanosoma brucei, 10.1016/s0166-6851(98)00176-5
  9. Duffieux F., Molecular characterisation of the first two enzymes of the pentose-phosphate pathway of trypanosoma brucei, 10.1074/jbc.m004266200
  10. Igoillo-Esteve Mariana, Maugeri Dante, Stern Ana L., Beluardi Paula, Cazzulo Juan J., The pentose phosphate pathway in Trypanosoma cruzi: a potential target for the chemotherapy of Chagas disease, 10.1590/s0001-37652007000400007
  11. Hee Lee Soo, Stephens Jennifer L., Englund Paul T., A fatty-acid synthesis mechanism specialized for parasitism, 10.1038/nrmicro1617
  12. Barrett Michael, Gilbert Ian, Perspectives for New Drugs Against Trypanosomiasis and Leishmaniasis, 10.2174/1568026024607427
  13. Müller Sylke, Redox and antioxidant systems of the malaria parasite Plasmodium falciparum : Antioxidant defence of Plasmodium, 10.1111/j.1365-2958.2004.04257.x
  14. Cordeiro Artur T., Thiemann Otavio H., Michels Paul A.M., Inhibition of Trypanosoma brucei glucose-6-phosphate dehydrogenase by human steroids and their effects on the viability of cultured parasites, 10.1016/j.bmc.2009.01.068
  15. Leroux Alejandro E., Maugeri Dante A., Opperdoes Fred R., Cazzulo Juan J., Nowicki Cristina, Comparative studies on the biochemical properties of  the malic enzymes from Trypanosoma cruzi and Trypanosoma brucei : Trypanosoma cruzi and T. brucei malic enzymes, 10.1111/j.1574-6968.2010.02142.x
  16. Brun, Acta Trop, 36, 289 (1979)
  17. Azema Laurent, Claustre Samantha, Alric Isabelle, Blonski Casimir, Willson Michèle, Perié Jacques, Baltz Theo, Tetaud Emmanuel, Bringaud Frédéric, Cottem Dominique, Opperdoes Frederik R., Barrett Michael P., Interaction of substituted hexose analogues with the Trypanosoma brucei hexose transporter, 10.1016/j.bcp.2003.09.005
  18. Ngo H., Tschudi C., Gull K., Ullu E., Double-stranded RNA induces mRNA degradation in Trypanosoma brucei, 10.1073/pnas.95.25.14687
  19. Bringaud Frédéric, Robinson Derrick R., Barradeau Sébastien, Biteau Nicolas, Baltz Dominique, Baltz Théo, Characterization and disruption of a new Trypanosoma brucei repetitive flagellum protein, using double-stranded RNA inhibition, 10.1016/s0166-6851(00)00319-4
  20. Wirtz Elizabeth, Leal Simone, Ochatt Claudia, Cross GeorgeA.M., A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma brucei, 10.1016/s0166-6851(99)00002-x
  21. Coustou Virginie, Biran Marc, Breton Marc, Guegan Fabien, Rivière Loïc, Plazolles Nicolas, Nolan Derek, Barrett Michael P., Franconi Jean-Michel, Bringaud Frédéric, Glucose-induced Remodeling of Intermediary and Energy Metabolism in ProcyclicTrypanosoma brucei, 10.1074/jbc.m709592200
  22. Rivière Loïc, van Weelden Susanne W. H., Glass Patricia, Vegh Patricia, Coustou Virginie, Biran Marc, van Hellemond Jaap J., Bringaud Frédéric, Tielens Aloysius G. M., Boshart Michael, Acetyl:Succinate CoA-transferase in ProcyclicTrypanosoma brucei : GENE IDENTIFICATION AND ROLE IN CARBOHYDRATE METABOLISM, 10.1074/jbc.m407513200
  23. Akerman Susan E., Müller Sylke, Peroxiredoxin-linked Detoxification of Hydroperoxides inToxoplasma gondii, 10.1074/jbc.m406367200
  24. Klein R. A., Linstead D. J., Wheeler M. V., Carbon dioxide fixation in trypanosomatids, 10.1017/s003118200005318x
  25. Harlow E. Lane D. (eds) (1988) Antibodies: A Laboratory Manual, pp. 471–502, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
  26. Sambrook J. Fritsch E. F. Maniatis T. (eds) (1989) Molecular Cloning: A Laboratory Manual, Chapters 18.47–18.74, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
  27. Coustou Virginie, Biran Marc, Besteiro Sébastien, Rivière Loïc, Baltz Théo, Franconi Jean-Michel, Bringaud Frédéric, Fumarate Is an Essential Intermediary Metabolite Produced by the ProcyclicTrypanosoma brucei, 10.1074/jbc.m601377200
  28. Tetaud Emmanuel, Giroud Christiane, Prescott Alan R, Parkin David W, Baltz Dominique, Biteau Nicolas, Baltz Théo, Fairlamb Alan H, Molecular characterisation of mitochondrial and cytosolic trypanothione-dependent tryparedoxin peroxidases in Trypanosoma brucei, 10.1016/s0166-6851(01)00320-6
  29. KOHL LINDA, SHERWIN TREVOR, GULL KEITH, Assembly of the Paraflagellar Rod and the Flagellum Attachment Zone Complex During the Trypanosoma brucei Cell Cycle, 10.1111/j.1550-7408.1999.tb04592.x
  30. Ansar Ahmed S., Gogal Robert M., Walsh Jane E., A new rapid and simple non-radioactive assay to monitor and determine the proliferation of lymphocytes: an alternative to [3H]thymidine incorporation assay, 10.1016/0022-1759(94)90396-4
  31. Räz B, Iten M, Grether-Bühler Y, Kaminsky R, Brun R, The Alamar Blue® assay to determine drug sensitivity of African trypanosomes (T.b. rhodesiense and T.b. gambiense) in vitro, 10.1016/s0001-706x(97)00079-x
  32. Ebikeme Charles, Hubert Jane, Biran Marc, Gouspillou Gilles, Morand Pauline, Plazolles Nicolas, Guegan Fabien, Diolez Philippe, Franconi Jean-Michel, Portais Jean-Charles, Bringaud Frédéric, Ablation of Succinate Production from Glucose Metabolism in the Procyclic Trypanosomes Induces Metabolic Switches to the Glycerol 3-Phosphate/Dihydroxyacetone Phosphate Shuttle and to Proline Metabolism, 10.1074/jbc.m110.124917
  33. Bolten Christoph J., Kiefer Patrick, Letisse Fabien, Portais Jean-Charles, Wittmann Christoph, Sampling for Metabolome Analysis of Microorganisms, 10.1021/ac0623888
  34. Kiefer Patrick, Nicolas Cécile, Letisse Fabien, Portais Jean-Charles, Determination of carbon labeling distribution of intracellular metabolites from single fragment ions by ion chromatography tandem mass spectrometry, 10.1016/j.ab.2006.06.032
  35. Boveris A, Sies H, Martino E E, Docampo R, Turrens J F, Stoppani A O, Deficient metabolic utilization of hydrogen peroxide inTrypanosoma cruzi, 10.1042/bj1880643
  36. Millard P., Letisse F., Sokol S., Portais J.-C., IsoCor: correcting MS data in isotope labeling experiments, 10.1093/bioinformatics/bts127
  37. Cannata J J B, Frasch A C C, Cataldi de Flombaum M A, Segura E L, Cazzulo J J, Two forms of ‘malic’ enzyme with different regulatory properties inTrypanosoma cruzi, 10.1042/bj1840409
  38. ORELLANO E, CAZZULO J, Purification and regulatory properties of the NADP-linked malic enzyme from Crithidia fasciculata, 10.1016/0166-6851(81)90072-4
  39. Gupta Shreedhara, Cordeiro Artur T., Michels Paul A.M., Glucose-6-phosphate dehydrogenase is the target for the trypanocidal action of human steroids, 10.1016/j.molbiopara.2010.12.006
  40. Ingram Alexandra K., Cross George A.M., Horn David, Genetic manipulation indicates that ARD1 is an essential Nα-acetyltransferase in Trypanosoma brucei, 10.1016/s0166-6851(00)00322-4
  41. Mannaert An, Downing Tim, Imamura Hideo, Dujardin Jean-Claude, Adaptive mechanisms in pathogens: universal aneuploidy in Leishmania, 10.1016/
  42. Cronín Ciaran N., Nolan Derek P., Paul Voorheis H., The enzymes of the classical pentose phosphate pathway display differential activities in procyclic and bloodstream forms ofTrypanosoma brucei, 10.1016/0014-5793(89)81154-8
  43. Creek Darren J., Chokkathukalam Achuthanunni, Jankevics Andris, Burgess Karl E. V., Breitling Rainer, Barrett Michael P., Stable Isotope-Assisted Metabolomics for Network-Wide Metabolic Pathway Elucidation, 10.1021/ac3018795
  44. Pantopoulos Kostas, Mueller Sebastian, Atzberger Ann, Ansorge Wilhelm, Stremmel Wolfgang, Hentze Matthias W., Differences in the Regulation of Iron Regulatory Protein-1 (IRP-1) by Extra- and Intracellular Oxidative Stress, 10.1074/jbc.272.15.9802
  45. He S., Dayton A., Kuppusamy P., Werbovetz K. A., Drew M. E., Induction of Oxidative Stress in Trypanosoma brucei by the Antitrypanosomal Dihydroquinoline OSU-40, 10.1128/aac.06386-11
  46. Sureda Antoni, Hebling Ulrike, Pons Antoni, Mueller Sebastian, Extracellular H2O2and not superoxide determines the compartment-specific activation of transferrin receptor by iron regulatory protein 1, 10.1080/10715760500164045
  47. Mueller Sebastian, Sensitive and nonenzymatic measurement of hydrogen peroxide in biological systems, 10.1016/s0891-5849(00)00261-6
  48. Michels Paul A.M., Bringaud Frédéric, Herman Murielle, Hannaert Véronique, Metabolic functions of glycosomes in trypanosomatids, 10.1016/j.bbamcr.2006.08.019
  49. Lamour N., Riviere L., Coustou V., Coombs G. H., Barrett M. P., Bringaud F., Proline Metabolism in Procyclic Trypanosoma brucei Is Down-regulated in the Presence of Glucose, 10.1074/jbc.m414274200
  50. van Weelden Susanne W. H., Fast Beate, Vogt Achim, van der Meer Pieter, Saas Joachim, van Hellemond Jaap J., Tielens Aloysius G. M., Boshart Michael, ProcyclicTrypanosoma bruceiDo Not Use Krebs Cycle Activity for Energy Generation, 10.1074/jbc.m213190200
  51. Bursell Einar, The Role of Proline in Energy Metabolism, Energy Metabolism in Insects (1981) ISBN:9781461592235 p.135-154, 10.1007/978-1-4615-9221-1_5
  52. Berriman M., The Genome of the African Trypanosome Trypanosoma brucei, 10.1126/science.1112642
  53. Hannaert V., Saavedra E., Duffieux F., Szikora J.-P., Rigden D. J., Michels P. A. M., Opperdoes F. R., Plant-like traits associated with metabolism of Trypanosoma parasites, 10.1073/pnas.0335769100
  54. Coustou Virginie, Besteiro Sébastien, Rivière Loïc, Biran Marc, Biteau Nicolas, Franconi Jean-Michel, Boshart Michael, Baltz Théo, Bringaud Frédéric, A Mitochondrial NADH-dependent Fumarate Reductase Involved in the Production of Succinate Excreted by ProcyclicTrypanosoma brucei, 10.1074/jbc.m500343200
  55. Ghozlane Amine, Bringaud Frédéric, Soueidan Hayssam, Dutour Isabelle, Jourdan Fabien, Thébault Patricia, Flux Analysis of theTrypanosoma bruceiGlycolysis Based on a Multiobjective-Criteria Bioinformatic Approach, 10.1155/2012/159423
  56. Bringaud F., Baltz D., Baltz T., Functional and molecular characterization of a glycosomal PPi-dependent enzyme in trypanosomatids: Pyruvate, phosphate dikinase, 10.1073/pnas.95.14.7963
  57. Luscher A., de Koning H., Maser P., Chemotherapeutic Strategies Against Trypanosoma brucei: Drug Targets vs. Drug Targeting, 10.2174/138161207780162809
  58. Suga Hiroyuki, Matsuda Fumio, Hasunuma Tomohisa, Ishii Jun, Kondo Akihiko, Implementation of a transhydrogenase-like shunt to counter redox imbalance during xylose fermentation in Saccharomyces cerevisiae, 10.1007/s00253-012-4298-3
  59. Naderer T., Ellis M. A., Sernee M. F., De Souza D. P., Curtis J., Handman E., McConville M. J., Virulence of Leishmania major in macrophages and mice requires the gluconeogenic enzyme fructose-1,6-bisphosphatase, 10.1073/pnas.0509196103
  60. Garami A., Disruption of mannose activation in Leishmania mexicana: GDP-mannose pyrophosphorylase is required for virulence, but not for viability, 10.1093/emboj/20.14.3657
  61. McConville Malcolm J., Naderer Thomas, Metabolic Pathways Required for the Intracellular Survival of Leishmania, 10.1146/annurev-micro-090110-102913
  62. Jiang Peng, Du Wenjing, Mancuso Anthony, Wellen Kathryn E., Yang Xiaolu, Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence, 10.1038/nature11776
  63. Bringaud Frederic, Multiple roles of proline transport and metabolism in trypanosomatids, 10.2741/3931
  64. Müller Ingrid B., Das Gupta Robin, Lüersen Kai, Wrenger Carsten, Walter Rolf D., Assessing the polyamine metabolism of Plasmodium falciparum as chemotherapeutic target, 10.1016/j.molbiopara.2008.03.008
  65. Birkholtz Lyn-Marie, Williams Marni, Niemand Jandeli, Louw Abraham I., Persson Lo, Heby Olle, Polyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilities, 10.1042/bj20110362
  66. Krauth-Siegel R. Luise, Comini Marcelo A., Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism, 10.1016/j.bbagen.2008.03.006