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Quantitation in PET using isotopes emitting prompt single gammas: application to yttrium-86.

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WALRAND, Stephan [UCL] Jamar, François [UCL] Mathieu, Isabelle [UCL] De Camps, Joëlle [UCL] Lonneux, Max [UCL] Sibomana, Mérence [UCL] Labar, Daniel [UCL] Michel, Christian [UCL] Pauwels, Stanislas [UCL]

Several yttrium-90 labelled somatostatin analogues are now available for cancer radiotherapy. After injection, a large amount of the compound is excreted via the urinary tract, while a variable part is trapped in the tumour(s), allowing the curative effect. Unfortunately, the compound may also be trapped in critical tissues such as kidney or bone marrow. As a consequence, a method for assessment of individual biodistribution and pharmacokinetics is required to predict the maximum dose that can be safely injected into patients. However, (90)Y, a pure beta(-)particle emitter, cannot be used for quantitative imaging. Yttrium-86 is a positron emitter that allows imaging of tissue uptake using a PET camera. In addition to the positron, (86)Y also emits a multitude of prompt single gamma-rays, leading to significant overestimation of uptake when using classical reconstruction methods. We propose a patient-dependent correction method based on sinogram tail fitting using an (86)Y point spread function library. When applied to abdominal phantom acquisition data, the proposed correction method significantly improved the accuracy of the quantification: the initial overestimation of background activity by 117% was reduced to 9%, while the initial error in respect of kidney uptake by 84% was reduced to 5%. In patient studies, the mean discrepancy between PET total body activity and the activity expected from urinary collections was reduced from 92% to 7%, showing the benefit of the proposed correction method.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2003
Journal information "European Journal of Nuclear Medicine and Molecular Imaging" - Vol. 30, no. 3, p. 354-361 (2003)
Peer reviewed yes
Publisher Springer (Heidelberg)
issn 1619-7070
e-issn 1619-7089
Publication status Publié
Affiliations UCL - MD/MINT - Département de médecine interne
UCL - (SLuc) Service de médecine nucléaire
MESH Subject Algorithms ; Gamma Rays ; Humans ; Maximum Allowable Concentration ; Models, Biological ; Neoplasms - metabolism - radionuclide imaging - radiotherapy ; Organ Specificity ; Quality Control ; Radiopharmaceuticals - diagnostic use - pharmacokinetics - urine ; Radiotherapy Dosage ; Receptors, Somatostatin - metabolism ; Tissue Distribution ; Tomography, Emission-Computed - methods - standards ; Whole-Body Counting - instrumentation - methods ; Yttrium Radioisotopes - pharmacokinetics - therapeutic use - urine
Keywords Yttrium-86 ; Quantitation ; Spurious coincidence ; Somatostatin analogue
Links
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Bibliographic reference WALRAND, Stephan ; Jamar, François ; Mathieu, Isabelle ; De Camps, Joëlle ; Lonneux, Max ; et. al. Quantitation in PET using isotopes emitting prompt single gammas: application to yttrium-86.. In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 30, no. 3, p. 354-361 (2003)
Permanent URL http://hdl.handle.net/2078.1/12878