User menu

Myocardial ischemia and increased heart work modulate the phosphorylation state of eukaryotic elongation factor-2.

Bibliographic reference Horman, Sandrine ; Beauloye, Christophe ; Vertommen, Didier ; Vanoverschelde, Jean-Louis ; Hue, Louis ; et. al. Myocardial ischemia and increased heart work modulate the phosphorylation state of eukaryotic elongation factor-2.. In: The Journal of biological chemistry, Vol. 278, no. 43, p. 41970-6 (2003)
Permanent URL
  1. Buttgereit F, Brand M D, A hierarchy of ATP-consuming processes in mammalian cells, 10.1042/bj3120163
  2. Beauloye Christophe, Marsin Anne-Sophie, Bertrand Luc, Vanoverschelde Jean-Louis, Rider Mark H, Hue Louis, The stimulation of heart glycolysis by increased workload does not require AMP-activated protein kinase but a wortmannin-sensitive mechanism, 10.1016/s0014-5793(02)03552-4
  3. J. Biol. Chem., 246, 2171 (1971)
  4. Wollenberger A., Onnen K., Hinterberger U., Rabitzsch G., Kleitke B., Myocardial Protein Synthesis in Acute Myocardial Hypoxia and Ischemia, 10.1159/000169341
  5. Bolster Douglas R., Crozier Stephen J., Kimball Scot R., Jefferson Leonard S., AMP-activated Protein Kinase Suppresses Protein Synthesis in Rat Skeletal Muscle through Down-regulated Mammalian Target of Rapamycin (mTOR) Signaling, 10.1074/jbc.c200171200
  6. Hardie D. Grahame, Carling David, Carlson Marian, THE AMP-ACTIVATED/SNF1 PROTEIN KINASE SUBFAMILY: Metabolic Sensors of the Eukaryotic Cell?, 10.1146/annurev.biochem.67.1.821
  7. Kemp Bruce E, Mitchelhill Ken I, Stapleton David, Michell Belinda J, Chen Zhi-Ping, Witters Lee A, Dealing with energy demand: the AMP-activated protein kinase, 10.1016/s0968-0004(98)01340-1
  8. DAVIES Stephen P., CARLING David, HARDIE D. Grahame, Tissue distribution of the AMP-activated protein kinase, and lack of activation by cyclic-AMP-dependent protein kinase, studied using a specific and sensitive peptide assay, 10.1111/j.1432-1033.1989.tb15185.x
  9. Horman Sandrine, Browne Gareth J., Krause Ulrike, Patel Jigna V., Vertommen Didier, Bertrand Luc, Lavoinne Alain, Hue Louis, Proud Christopher G., Rider Mark H., Activation of AMP-Activated Protein Kinase Leads to the Phosphorylation of Elongation Factor 2 and an Inhibition of Protein Synthesis, 10.1016/s0960-9822(02)01077-1
  10. Marsin A-S., Bertrand† L., Rider M.H., Deprez J., Beauloye C., Vincent‡ M.F., Van den Berghe‡ G., Carling D., Hue L., Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia, 10.1016/s0960-9822(00)00742-9
  11. Taegtmeyer H, Hems R, Krebs H A, Utilization of energy-providing substrates in the isolated working rat heart, 10.1042/bj1860701
  12. Woods Angela, Vertommen Didier, Neumann Dietbert, Türk Roland, Bayliss Jayne, Schlattner Uwe, Wallimann Theo, Carling David, Rider Mark H., Identification of Phosphorylation Sites in AMP-activated Protein Kinase (AMPK) for Upstream AMPK Kinases and Study of Their Roles by Site-directed Mutagenesis, 10.1074/jbc.m303946200
  13. PROUD CHRISTOPHER G., Protein Phosphorylation in Translational Control, Current Topics in Cellular Regulation (1992) ISBN:9780121528324 p.243-369, 10.1016/b978-0-12-152832-4.50008-2
  14. Vincent M. F., Marangos P. J., Gruber H. E., van den Berghe G., Inhibition by AICA Riboside of Gluconeogenesis in Isolated Rat Hepatocytes, 10.2337/diab.40.10.1259
  15. Methods of Enzymatic Analysis, 8, 500 (1984)
  16. Bradford Marion M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, 10.1016/0003-2697(76)90527-3
  17. Weng Qing-Ping, Kozlowski Mark, Belham Christopher, Zhang Aihua, Comb Michael J., Avruch Joseph, Regulation of the p70 S6 Kinase by Phosphorylationin Vivo : ANALYSIS USING SITE-SPECIFIC ANTI-PHOSPHOPEPTIDE ANTIBODIES, 10.1074/jbc.273.26.16621
  18. DIGGLE Tricia A., REDPATH Nicholas T., HEESOM Kate J., DENTON Richard M., Regulation of protein-synthesis elongation-factor-2 kinase by cAMP in adipocytes, 10.1042/bj3360525
  19. McLeod Laura E, Proud Christopher G, ATP depletion increases phosphorylation of elongation factor eEF2 in adult cardiomyocytes independently of inhibition of mTOR signalling, 10.1016/s0014-5793(02)03582-2
  20. Dubbelhuis Peter F, Meijer Alfred J, Hepatic amino acid-dependent signaling is under the control of AMP-dependent protein kinase, 10.1016/s0014-5793(02)02815-6
  21. Krause Ulrike, Bertrand Luc, Hue Louis, Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes : Inhibition of p70S6K activation by AMPK, 10.1046/j.1432-1033.2002.03074.x
  22. Hovland R., Eikhom T.S., Proud C.G., Cressey L.I., Lanotte M., Døskeland S.O., Houge G., cAMP inhibits translation by inducing Ca2+/calmodulin-independent elongation factor 2 kinase activity in IPC-81 cells, 10.1016/s0014-5793(99)00039-3
  23. Lawrence J, PHAS/4E-BPs as regulators of mRNA translation and cell proliferation, 10.1016/s0968-0004(97)01101-8
  24. McLeod Laura E, Wang Lijun, Proud Christopher G, β-Adrenergic agonists increase phosphorylation of elongation factor 2 in cardiomyocytes without eliciting calcium-independent eEF2 kinase activity, 10.1016/s0014-5793(01)02100-7
  25. Hait William N., Ward Michael D., Trakht Ilya N., Ryazanov Alexey G., Elongation factor-2 kinase: immunological evidence for the existence of tissue-specific isoforms, 10.1016/s0014-5793(96)01140-4
  26. Beauloye C., Bertrand L., Krause U., Marsin A.-S., Dresselaers T., Vanstapel F., Vanoverschelde J.-L., Hue L., No-Flow Ischemia Inhibits Insulin Signaling in Heart by Decreasing Intracellular pH, 10.1161/01.res.88.5.513
  27. Dorovkov Maxim V., Pavur Karen S., Petrov Alexey N., Ryazanov Alexey G., Regulation of Elongation Factor-2 Kinase by pH†, 10.1021/bi026494p
  28. Alirezaei Mehrdad, Marin Philippe, Nairn Angus C., Glowinski Jacques, Prémont Joël, Inhibition of protein synthesis in cortical neurons during exposure to hydrogen peroxide : H 2O 2 inhibits protein synthesis in neurons, 10.1046/j.1471-4159.2001.00105.x
  29. Stern M. D., Silverman H. S., Houser S. R., Josephson R. A., Capogrossi M. C., Nichols C. G., Lederer W. J., Lakatta E. G., Anoxic contractile failure in rat heart myocytes is caused by failure of intracellular calcium release due to alteration of the action potential., 10.1073/pnas.85.18.6954
  30. Am. J. Physiol., 269, C690 (1995)
  31. Welsh Gavin I, Miller Christa M, Loughlin A.Jane, Price Nigel T, Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase-3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin, 10.1016/s0014-5793(97)01548-2
  32. Am. J. Physiol., 281, H161 (2001)
  33. Wang Lijun, Proud Christopher G, Regulation of the phosphorylation of elongation factor 2 by MEK-dependent signalling in adult rat cardiomyocytes, 10.1016/s0014-5793(02)03536-6
  34. Wang X., Regulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase, 10.1093/emboj/20.16.4370
  35. REDPATH Nicholas T., PRICE Nigel T., SEVERINOV Konstantin V., PROUD Christopher G., Regulation of elongation factor-2 by multisite phosphorylation, 10.1111/j.1432-1033.1993.tb17809.x
  36. Am. J. Physiol., 278, H1056 (2000)
  37. WANG Xuemin, JANMAAT Maarten, BEUGNET Anne, PAULIN Fiona E.M., PROUD Christopher G., Evidence that the dephosphorylation of Ser535 in the ∊-subunit of eukaryotic initiation factor (eIF) 2B is insufficient for the activation of eIF2B by insulin, 10.1042/bj20020677
  38. Am. J. Physiol., 246, C247 (1984)
  39. Lefebvre Véronique, Méchin Marie-Claire, Louckx Marc P., Rider Mark H., Hue Louis, Signaling Pathway Involved in the Activation of Heart 6-Phosphofructo-2-kinase by Insulin, 10.1074/jbc.271.37.22289