| Authors |
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| Document type |
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Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't
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| Abstract |
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The leader protein of Theiler's virus was previously shown to block the production of alpha/beta interferon by infected cells. Here, we observed that expression of the leader protein in infected cells triggered subcellular redistribution of a nucleus-target green fluorescent protein. It enhanced redistribution of the nuclear polypyrimidine tract-binding protein but had no influence on the localization of the nuclear splicing factor SC-35. The leader protein also interfered with trafficking of the cytoplasmic interferon regulatory factor 3, a factor critical for transcriptional activation of alpha/beta interferon genes. |
| Access type |
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Accès libre
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| Publication date |
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2004 |
| Journal information |
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"Journal of Virology" - Vol. 78, no. 8, p. 4357-4362 (2004) |
| Peer reviewed |
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yes |
| Publisher |
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American Society for Microbiology ((United States) [S.l.])
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| issn |
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0022-538X |
| e-issn |
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1098-5514 |
| Publication status |
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Publié |
| Affiliation |
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UCL
- MD/MIGE - Département de microbiologie, d'immunologie et de génétique
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| MESH Subject |
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Active Transport, Cell Nucleus ; Animals ; BALB 3T3 Cells ; Cell Line ; Cytoplasm - metabolism - virology ; DNA-Binding Proteins - metabolism ; Green Fluorescent Proteins ; Interferon Regulatory Factor-3 ; Luminescent Proteins - metabolism ; Mice ; Mutation ; Nuclear Localization Signals - genetics - physiology ; Nuclear Proteins - metabolism ; Recombinant Fusion Proteins - metabolism ; Theilovirus - genetics - pathogenicity - physiology ; Transcription Factors - metabolism ; Viral Proteins - physiology
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