User menu

Interaction of double-stranded RNA-dependent protein kinase (PKR) with the death receptor signaling pathway in amyloid beta (Abeta)-treated cells and in APPSLPS1 knock-in mice.

Bibliographic reference Couturier, Julien ; Morel, Milena ; Pontcharraud, Raymond ; Gontier, Virginie ; Fauconneau, Bernard ; et. al. Interaction of double-stranded RNA-dependent protein kinase (PKR) with the death receptor signaling pathway in amyloid beta (Abeta)-treated cells and in APPSLPS1 knock-in mice.. In: Journal of Biological Chemistry, Vol. 285, no. 2, p. 1272-1282 (2010)
Permanent URL
  1. Paccalin Marc, Pain-Barc Stéphanie, Pluchon Claudette, Paul Chloé, Besson Marie-Noelle, Carret-Rebillat Anne-Sophie, Rioux-Bilan Agnès, Gil Roger, Hugon Jacques, Activated mTOR and PKR Kinases in Lymphocytes Correlate with Memory and Cognitive Decline in Alzheimer’s Disease, 10.1159/000095562
  2. Peel A, Activation of the cell stress kinase PKR in Alzheimer's disease and human amyloid precursor protein transgenic mice, 10.1016/s0969-9961(03)00086-x
  3. Damjanac M. Page G. Ragot S. Laborie G. Gil R. Hugon J. Paccalin M. (2009) J. Cell Mol. Med., in press
  4. Gil Jesús, Esteban Mariano, The interferon-induced protein kinase (PKR), triggers apoptosis through FADD-mediated activation of caspase 8 in a manner independent of Fas and TNF-α receptors, 10.1038/sj.onc.1203710
  5. Cantarella G, Uberti D, Carsana T, Lombardo G, Bernardini R, Memo M, Neutralization of TRAIL death pathway protects human neuronal cell line from β-amyloid toxicity, 10.1038/sj.cdd.4401143
  6. Screaton R. A., Kiessling S., Sansom O. J., Millar C. B., Maddison K., Bird A., Clarke A. R., Frisch S. M., Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: A potential link between genome surveillance and apoptosis, 10.1073/pnas.0431215100
  7. Su Joseph H, Anderson Aileen J, Cribbs David H, Tu Christina, Tong Liqi, Kesslack Patrick, Cotman Carl W, Fas and Fas Ligand are associated with neuritic degeneration in the AD brain and participate in β-amyloid-induced neuronal death, 10.1016/s0969-9961(02)00019-0
  8. Wu Chuang-Kuo, Thal Leon, Pizzo Donald, Hansen Lawrance, Masliah Eliezer, Geula Changiz, Apoptotic signals within the basal forebrain cholinergic neurons in Alzheimer's disease, 10.1016/j.expneurol.2005.06.020
  9. Nishimura Toru, Akiyama Haruhiko, Yonehara Shin, Kondo Hiromi, Ikeda Kenji, Kato Masanori, Iseki Eizo, Kosaka Kenji, Fas antigen expression in brains of patients with Alzheimer-type dementia, 10.1016/0006-8993(95)00699-q
  10. Simmons, Mol. Pharmacol., 45, 373 (1994)
  11. Jammi Narasimham V., Whitby Landon R., Beal Peter A., Small molecule inhibitors of the RNA-dependent protein kinase, 10.1016/s0006-291x(03)01318-4
  12. Dignam J. D., Lebovitz R. M., Roeder R. G., Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei, 10.1093/nar/11.5.1475
  13. Chang Raymond Chuen-Chung, Suen Ka-Chun, Ma Chi-Him, Elyaman Wassim, Ng Ho-Keung, Hugon Jacques, Involvement of double-stranded RNA-dependent protein kinase and phosphorylation of eukaryotic initiation factor-2α in neuronal degeneration : PKR and eIF2α in neurodegeneration, 10.1046/j.1471-4159.2002.01237.x
  14. Casas Caty, Sergeant Nicolas, Itier Jean-Michel, Blanchard Véronique, Wirths Oliver, van der Kolk Nicolien, Vingtdeux Valérie, van de Steeg Evita, Ret Gwenaëlle, Canton Thierry, Drobecq Hervé, Clark Allan, Bonici Bruno, Delacourte André, Benavides Jesús, Schmitz Christoph, Tremp Günter, Bayer Thomas A., Benoit Patrick, Pradier Laurent, Massive CA1/2 Neuronal Loss with Intraneuronal and N-Terminal Truncated Aβ42 Accumulation in a Novel Alzheimer Transgenic Model, 10.1016/s0002-9440(10)63388-3
  15. Damjanac Milena, Rioux Bilan Agnès, Paccalin Marc, Pontcharraud Raymond, Fauconneau Bernard, Hugon Jacques, Page Guylène, Dissociation of Akt/PKB and ribosomal S6 kinase signaling markers in a transgenic mouse model of Alzheimer’s disease, 10.1016/j.nbd.2007.09.008
  16. Romano Patrick R., Garcia-Barrio Minerva T., Zhang Xiaolong, Wang Qizhi, Taylor Deborah R., Zhang Fan, Herring Christopher, Mathews Michael B., Qin Jun, Hinnebusch Alan G., Autophosphorylation in the Activation Loop Is Required for Full Kinase Activity In Vivo of Human and Yeast Eukaryotic Initiation Factor 2α Kinases PKR and GCN2, 10.1128/mcb.18.4.2282
  17. Scaffidi C., Volkland J., Blomberg I., Hoffmann I., Krammer P. H., Peter M. E., Phosphorylation of FADD/ MORT1 at Serine 194 and Association with a 70-kDa Cell Cycle-Regulated Protein Kinase, 10.4049/jimmunol.164.3.1236
  18. Chen G., Bhojani M. S., Heaford A. C., Chang D. C., Laxman B., Thomas D. G., Griffin L. B., Yu J., Coppola J. M., Giordano T. J., Lin L., Adams D., Orringer M. B., Ross B. D., Beer D. G., Rehemtulla A., Phosphorylated FADD induces NF- B, perturbs cell cycle, and is associated with poor outcome in lung adenocarcinomas, 10.1073/pnas.0500397102
  19. Christensen Kurt D, Roberts J Scott, Royal Charmaine D M, Fasaye Grace-Ann, Obisesan Thomas, Cupples L Adrienne, Whitehouse Peter J, Butson Melissa Barber, Linnenbringer Erin, Relkin Norman R, Farrer Lindsay, Cook-Deegan Robert, Green Robert C, Incorporating ethnicity into genetic risk assessment for Alzheimer disease: the REVEAL study experience, 10.1097/gim.0b013e318164e4cf
  20. Barrier L. Ingrand S. Fauconneau B. Page G. (2008) Neurobiol Aging, in press
  21. Garcia M. A., Gil J., Ventoso I., Guerra S., Domingo E., Rivas C., Esteban M., Impact of Protein Kinase PKR in Cell Biology: from Antiviral to Antiproliferative Action, 10.1128/mmbr.00027-06
  22. Cuddihy Andrew R, Hoi-Tao Wong Andrew, Wai Ning Tam Nancy, Li Suiyang, Koromilas Antonis E, The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro, 10.1038/sj.onc.1202620
  23. Gil Jesús, Alcamí José, Esteban Mariano, Activation of NF-κB by the dsRNA-dependent protein kinase, PKR involves the IκB kinase complex, 10.1038/sj.onc.1203448
  24. Lafay-Chebassier Claire, Paccalin Marc, Page Guylene, Barc-Pain Stephanie, Perault-Pochat Marie Christine, Gil Roger, Pradier Laurent, Hugon Jacques, mTOR/p70S6k signalling alteration by Abeta exposure as well as in APP-PS1 transgenic models and in patients with Alzheimer's disease, 10.1111/j.1471-4159.2005.03187.x
  25. Goh K. C., The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin, 10.1093/emboj/19.16.4292
  26. Balachandran Siddharth, Kim Caryn N., Yeh Wen-Chen, Mak Tak W., Bhalla Kapil, Barber Glen N., Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling, 10.1093/emboj/17.23.6888
  27. Ramana Chilakamarti V., Grammatikakis Nicholas, Chernov Mikhail, Nguyen Hannah, Chuan Goh Kee, Williams Bryan R.G., Stark George R., Regulation of c-myc expression by IFN-γ through Stat1-dependent and -independent pathways, 10.1093/emboj/19.2.263
  28. Guerra Susana, López-Fernández Luis A., García María Angel, Zaballos Angel, Esteban Mariano, Human Gene Profiling in Response to the Active Protein Kinase, Interferon-induced Serine/threonine Protein Kinase (PKR), in Infected Cells : INVOLVEMENT OF THE TRANSCRIPTION FACTOR ATF-3 IN PKR-INDUCED APOPTOSIS, 10.1074/jbc.m511983200
  29. Ivins Kathryn J., Thornton Phillip L., Rohn Troy T., Cotman Carl W., Neuronal Apoptosis Induced by β-Amyloid Is Mediated by Caspase-8, 10.1006/nbdi.1999.0268
  30. Garcia-Bustos Jose, Heitman Joseph, Hall Michael N., Nuclear protein localization, 10.1016/0304-4157(91)90013-m
  31. Jeffrey I, Nuclear Localization of the Interferon-Inducible Protein Kinase PKR in Human Cells and Transfected Mouse Cells, 10.1006/excr.1995.1126
  32. Gómez-Angelats M, Cidlowski J A, Molecular evidence for the nuclear localization of FADD, 10.1038/sj.cdd.4401237
  33. Nagata S., Golstein P., The Fas death factor, 10.1126/science.7533326
  34. Bayer Thomas A., Breyhan Henning, Duan Kailai, Rettig Jens, Wirths Oliver, Intraneuronal β-Amyloid Is a Major Risk Factor – Novel Evidence from the APP/PS1KI Mouse Model, 10.1159/000113684
  35. Pei Jin-Jing, Hugon Jacques, mTOR-dependent signalling in Alzheimer's disease, 10.1111/j.1582-4934.2008.00509.x
  36. Engidawork Ephrem, Gulesserian Talin, Yoo Byong Chul, Cairns Nigel, Lubec Gert, Alteration of Caspases and Apoptosis-Related Proteins in Brains of Patients with Alzheimer's Disease, 10.1006/bbrc.2001.4306
  37. Kalai, Cell Death Differ., 14, 1050 (2007)
  38. Bennett Richard L., Blalock William L., May W. Stratford, Serine 18 Phosphorylation of RAX, the PKR Activator, Is Required for PKR Activation and Consequent Translation Inhibition, 10.1074/jbc.m403321200
  39. Patel R. C., PACT, a protein activator of the interferon-induced protein kinase, PKR, 10.1093/emboj/17.15.4379
  40. Stegh A. H., DEDD, a novel death effector domain-containing protein, targeted to the nucleolus, 10.1093/emboj/17.20.5974
  41. Zheng Lixin, Schickling Olaf, Peter Marcus E., Lenardo Michael J., The Death Effector Domain-associated Factor Plays Distinct Regulatory Roles in the Nucleus and Cytoplasm, 10.1074/jbc.m102799200
  42. Checler Frederic, Sunyach Claire, Pardossi-Piquard Raphaelle, Sevalle Jean, Vincent Bruno, Kawarai Toshitaka, Girardot Nadege, George-Hyslop Peter St, da Costa Cristine, The γ /η-Secretase-Derived APP Intracellular Domain Fragments Regulate p53, 10.2174/156720507781788945
  43. Buggia-Prevot Virginie, Sevalle Jean, Rossner Steffen, Checler Frédéric, NFκB-dependent Control ofBACE1Promoter Transactivation by Aβ42, 10.1074/jbc.m706579200
  44. Uberti Daniela, Lanni Cristina, Racchi Marco, Govoni Stefano, Memo Maurizio, Conformationally Altered p53: A Putative Peripheral Marker for Alzheimer’s Disease, 10.1159/000113704
  45. Chiba T, Yamada M, Sasabe J, Terashita K, Shimoda M, Matsuoka M, Aiso S, Amyloid-β causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons, 10.1038/mp.2008.105
  46. Suen Ka-Chun, Yu Man-Shan, So Kwok-Fai, Chang Raymond Chuen-Chung, Hugon Jacques, Upstream Signaling Pathways Leading to the Activation of Double-stranded RNA-dependent Serine/Threonine Protein Kinase in β-Amyloid Peptide Neurotoxicity, 10.1074/jbc.m306503200
  47. Zhu Xiongwei, Lee Hyoung-gon, Raina Arun K., Perry George, Smith Mark A., The Role of Mitogen-Activated Protein Kinase Pathways in Alzheimer’s Disease, 10.1159/000067426
  48. Onuki Reiko, Bando Yoshio, Suyama Eigo, Katayama Taiichi, Kawasaki Hiroaki, Baba Tadashi, Tohyama Masaya, Taira Kazunari, An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease, 10.1038/sj.emboj.7600049
  49. Chang Raymond C. C., Wong Ada K. Y., Ng Ho-Keung, Hugon Jacques, Phosphorylation of eukaryotic initiation factor-2α (eIF2α) is associated with neuronal degeneration in Alzheimerʼs disease : , 10.1097/00001756-200212200-00011
  50. Peel Alyson L., PKR Activation in Neurodegenerative Disease, 10.1093/jnen/63.2.97
  51. Page G., Rioux Bilan A., Ingrand S., Lafay-Chebassier C., Pain S., Perault Pochat M.C., Bouras C., Bayer T., Hugon J., Activated double-stranded RNA-dependent protein kinase and neuronal death in models of Alzheimer’s disease, 10.1016/j.neuroscience.2006.01.047