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The effect of clinical covariates on the diagnostic and prognostic value of soluble mesothelin and megakaryocyte potentiating factor

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Hollevoet, Kevin Nackaerts, Kristiaan Thas, Olivier Thimpont, Joël Germonpré, Paul Legrand, Catherine [UCL] van Meerbeeck, Jan P

SM and MPF levels were affected by the same clinical covariates, which also had a significant impact on their diagnostic and prognostic value. To improve the interpretation of biomarker results, age, GFR, and BMI should be routinely recorded. Approaches to account for these covariates require further validation, as does the prognostic value of SM and MPF.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2012
Language Anglais
Journal information "Chest" - Vol. 141, no. 2, p. 477-484 (2012)
Peer reviewed yes
issn 0012-3692
e-issn 1931-3543
Publication status Publié
Affiliation UCL - SSH/LIDAM/ISBA - Institut de Statistique, Biostatistique et Sciences Actuarielles
MESH Subject Age Factors ; Linear Models ; Male ; Mesothelioma ; Middle Aged ; Neoplasm Staging ; Pleural Neoplasms ; Prognosis ; Proportional Hazards Models ; Prospective Studies ; Tumor Markers, Biological ; Aged ; Area Under Curve ; Body Mass Index ; Case-Control Studies ; Female ; GPI-Linked Proteins ; Glomerular Filtration Rate ; Humans
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Bibliographic reference Hollevoet, Kevin ; Nackaerts, Kristiaan ; Thas, Olivier ; Thimpont, Joël ; Germonpré, Paul ; et. al. The effect of clinical covariates on the diagnostic and prognostic value of soluble mesothelin and megakaryocyte potentiating factor. In: Chest, Vol. 141, no. 2, p. 477-484 (2012)
Permanent URL http://hdl.handle.net/2078.1/127126