Wright, C. W.
Philipson, J. D.
Awe, S. O.
Kirby, G. C.
Warhurst, D. C.
Quetin-Leclercq, Joëlle
[UCL]
Angenot, Luc
Eight naturally occurring anhydronium bases and the synthetic quaternary compound Nb-methylharmalane were tested against Plasmodium falciparun (strain K1) in vitro. Cryptolepine was found to have similar activity to that of chloroquine but alstonine, 5,6-dihydroflavopereirine, matadine, Nb-methylharmalane, melinonine F, normelinonine F, strychnoxanthine and serpentine were found to have little activity. Cryptolepine, given orally to mice infected with Plasmodium berghei berghei was found to have moderate antimalarial activity; parasitemia was suppressed by 80% at 50 mg/kg/day.
Bibliographic reference |
Wright, C. W. ; Philipson, J. D. ; Awe, S. O. ; Kirby, G. C. ; Warhurst, D. C. ; et. al. Antimalarial activity of cryptolepine and some other anhydronium bases. In: Phytotherapy Research : an international journal devoted to medical and scientific research on plants and plant products, Vol. 10, no.4, p. 361-363 (1996) |
Permanent URL |
http://hdl.handle.net/2078.1/127001 |