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Nasal epithelium integrity, environmental stressors, and allergic sensitization: a biomarker study in adolescents.

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Sardella, Antonia [UCL] Voisin, Catherine [UCL] Nickmilder, Marc [UCL] Dumont, Xavier [UCL] Annesi-Maesano, Isabella Bernard, Alfred [UCL]

Changes in the airways epithelium caused by environmental insults might play a role in the development of allergic rhinitis. We measured albumin and Clara cell protein (CC16) in the nasal lavage fluid (NALF) from 474 adolescents (263 girls and 211 boys). The NALF CC16/albumin ratio, integrating the permeability and cellular integrity of the nasal epithelium, decreased mostly with time spent in chlorinated pools. In boys, a lower CC16/albumin ratio in NALF was associated with an increased risk of house dust mite sensitization. The results suggest that the CC16/albumin ratio in NALF can be used to detect nasal epithelium alterations linked to allergic sensitization.

Document type Article de périodique (Journal article)
Access type Accès restreint
Publication date 2012
Language Anglais
Journal information "Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals" - Vol. 17, no.4, p. 309-18 (2012)
Peer reviewed yes
issn 1354-750X
e-issn 1366-5804
Publication status Publié
Affiliation UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology
MESH Subject Adolescent ; Nasal Lavage Fluid ; Nasal Mucosa ; Permeability ; Pollen ; Pyroglyphidae ; Regression Analysis ; Serum Albumin ; Urea ; Uteroglobin ; Animals ; Biological Markers ; Environmental Exposure ; Female ; Humans ; Hypersensitivity ; Immunoglobulin E ; Male
Links
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Bibliographic reference Sardella, Antonia ; Voisin, Catherine ; Nickmilder, Marc ; Dumont, Xavier ; Annesi-Maesano, Isabella ; et. al. Nasal epithelium integrity, environmental stressors, and allergic sensitization: a biomarker study in adolescents.. In: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, Vol. 17, no.4, p. 309-18 (2012)
Permanent URL http://hdl.handle.net/2078.1/126909