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IL-22 Is Mainly Produced by IFNγ-Secreting Cells but Is Dispensable for Host Protection against Mycobacterium tuberculosis Infection.

Bibliographic reference Behrends, Jochen ; Renauld, Jean-Christophe ; Ehlers, Stefan ; Hölscher, Christoph. IL-22 Is Mainly Produced by IFNγ-Secreting Cells but Is Dispensable for Host Protection against Mycobacterium tuberculosis Infection.. In: PLoS One, Vol. 8, no.2, p. e57379 (2013)
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  1. Afif Waqqas, Loftus Edward V., Safety Profile of IBD Therapeutics: Infectious Risks, 10.1016/j.gtc.2009.07.005
  2. Ehlers S., Tumor Necrosis Factor and Its Blockade in Granulomatous Infections: Differential Modes of Action of Infliximab and Etanercept?, 10.1086/429998
  3. Solovic I., Sester M., Gomez-Reino J. J., Rieder H. L., Ehlers S., Milburn H. J., Kampmann B., Hellmich B., Groves R., Schreiber S., Wallis R. S., Sotgiu G., Scholvinck E. H., Goletti D., Zellweger J. P., Diel R., Carmona L., Bartalesi F., Ravn P., Bossink A., Duarte R., Erkens C., Clark J., Migliori G. B., Lange C., The risk of tuberculosis related to tumour necrosis factor antagonist therapies: a TBNET consensus statement, 10.1183/09031936.00028510
  4. Stallmach Andreas, Hagel Stefan, Bruns Tony, Adverse effects of biologics used for treating IBD, 10.1016/j.bpg.2010.01.002
  5. Reiling Norbert, Ehlers Stefan, Hölscher Christoph, MyDths and un-TOLLed truths: Sensor, instructive and effector immunity to tuberculosis, 10.1016/j.imlet.2007.11.015
  6. Cooper Andrea M., Cell-Mediated Immune Responses in Tuberculosis, 10.1146/annurev.immunol.021908.132703
  7. Orme I. M., Andersen P., Boom W. H., T Cell Response to Mycobacterium tuberculosis, 10.1093/infdis/167.6.1481
  8. Flynn JoAnne L., Goldstein Marsha M., Chan John, Triebold Karla J., Pfeffer Klaus, Lowenstein Charles J., Schrelber Robert, Mak Tak W., Bloom Barry R., Tumor necrosis factor-α is required in the protective immune response against mycobacterium tuberculosis in mice, 10.1016/1074-7613(95)90001-2
  9. Flynn J. L., An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection, 10.1084/jem.178.6.2249
  10. Pearl John E., Saunders Bernadette, Ehlers Stefan, Orme Ian M., Cooper Andrea M., Inflammation and Lymphocyte Activation during Mycobacterial Infection in the Interferon-γ-Deficient Mouse, 10.1006/cimm.2001.1819
  11. Hänsch Holger C. R., Smith Debbie A., Mielke Martin E. A., Hahn Helmut, Bancroft Gregory J., Ehlers Stefan, Mechanisms of granuioma formation in murine Mycobacterium avium infection: the contribution of CD4+ T cells, 10.1093/intimm/8.8.1299
  12. Cooper A, The protective immune response to Mycobacterium tuberculosis, 10.1016/0952-7915(95)80096-4
  13. Ehlers Stefan, Benini Jochen, Held Heinz-Dieter, Roeck Christiane, Alber Gottfried, Uhlig Stefan, αβ T Cell Receptor-positive Cells and Interferon-γ, but not Inducible Nitric Oxide Synthase, Are Critical for Granuloma Necrosis in a Mouse Model of Mycobacteria-induced Pulmonary Immunopathology, 10.1084/jem.194.12.1847
  14. Davis J. Muse, Ramakrishnan Lalita, The Role of the Granuloma in Expansion and Dissemination of Early Tuberculous Infection, 10.1016/j.cell.2008.11.014
  15. Volkman H. E., Pozos T. C., Zheng J., Davis J. M., Rawls J. F., Ramakrishnan L., Tuberculous Granuloma Induction via Interaction of a Bacterial Secreted Protein with Host Epithelium, 10.1126/science.1179663
  16. Ehlers Stefan, TB or not TB? Fishing for Molecules Making Permissive Granulomas, 10.1016/j.chom.2009.12.010
  17. Zhou Liang, Chong Mark M.W., Littman Dan R., Plasticity of CD4+ T Cell Lineage Differentiation, 10.1016/j.immuni.2009.05.001
  18. Zhu J., Paul W. E., CD4 T cells: fates, functions, and faults, 10.1182/blood-2008-05-078154
  19. Holscher C., Atkinson R. A., Arendse B., Brown N., Myburgh E., Alber G., Brombacher F., A Protective and Agonistic Function of IL-12p40 in Mycobacterial Infection, 10.4049/jimmunol.167.12.6957
  20. Khader S. A., Pearl J. E., Sakamoto K., Gilmartin L., Bell G. K., Jelley-Gibbs D. M., Ghilardi N., deSauvage F., Cooper A. M., IL-23 Compensates for the Absence of IL-12p70 and Is Essential for the IL-17 Response during Tuberculosis but Is Dispensable for Protection and Antigen-Specific IFN-  Responses if IL-12p70 Is Available, 10.4049/jimmunol.175.2.788
  21. Langrish Claire L., Chen Yi, Blumenschein Wendy M., Mattson Jeanine, Basham Beth, Sedgwick Jonathan D., McClanahan Terrill, Kastelein Robert A., Cua Daniel J., IL-23 drives a pathogenic T cell population that induces autoimmune inflammation, 10.1084/jem.20041257
  22. Murphy Craig A., Langrish Claire L., Chen Yi, Blumenschein Wendy, McClanahan Terrill, Kastelein Robert A., Sedgwick Jonathon D., Cua Daniel J., Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation, 10.1084/jem.20030896
  23. Umemura M., Yahagi A., Hamada S., Begum M. D., Watanabe H., Kawakami K., Suda T., Sudo K., Nakae S., Iwakura Y., Matsuzaki G., IL-17-Mediated Regulation of Innate and Acquired Immune Response against Pulmonary Mycobacterium bovis Bacille Calmette-Guerin Infection, 10.4049/jimmunol.178.6.3786
  24. Okamoto Yoshida Y., Umemura M., Yahagi A., O'Brien R. L., Ikuta K., Kishihara K., Hara H., Nakae S., Iwakura Y., Matsuzaki G., Essential Role of IL-17A in the Formation of a Mycobacterial Infection-Induced Granuloma in the Lung, 10.4049/jimmunol.0903332
  25. Khader Shabaana A, Bell Guy K, Pearl John E, Fountain Jeffrey J, Rangel-Moreno Javier, Cilley Garth E, Shen Fang, Eaton Sheri M, Gaffen Sarah L, Swain Susan L, Locksley Richard M, Haynes Laura, Randall Troy D, Cooper Andrea M, IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge, 10.1038/ni1449
  26. Werninghaus Kerstin, Babiak Anna, Groß Olaf, Hölscher Christoph, Dietrich Harald, Agger Else Marie, Mages Jörg, Mocsai Attila, Schoenen Hanne, Finger Katrin, Nimmerjahn Falk, Brown Gordon D., Kirschning Carsten, Heit Antje, Andersen Peter, Wagner Hermann, Ruland Jürgen, Lang Roland, Adjuvanticity of a synthetic cord factor analogue for subunitMycobacterium tuberculosisvaccination requires FcRγ–Syk–Card9–dependent innate immune activation, 10.1084/jem.20081445
  27. Cruz Andrea, Fraga Alexandra G., Fountain Jeffrey J., Rangel-Moreno Javier, Torrado Egídio, Saraiva Margarida, Pereira Daniela R., Randall Troy D., Pedrosa Jorge, Cooper Andrea M., Castro António G., Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection withMycobacterium tuberculosis, 10.1084/jem.20100265
  28. Lockhart E., Green A. M., Flynn J. L., IL-17 Production Is Dominated by    T Cells rather than CD4 T Cells during Mycobacterium tuberculosis Infection, 10.4049/jimmunol.177.7.4662
  29. Torrado Egídio, Robinson Richard T., Cooper Andrea M., Cellular response to mycobacteria: balancing protection and pathology, 10.1016/
  30. Renauld Jean-Christophe, Class II cytokine receptors and their ligands: Key antiviral and inflammatory modulators, 10.1038/nri1153
  31. Dumoutier L., Louahed J., Renauld J.-C., Cloning and Characterization of IL-10-Related T Cell-Derived Inducible Factor (IL-TIF), a Novel Cytokine Structurally Related to IL-10 and Inducible by IL-9, 10.4049/jimmunol.164.4.1814
  32. Liang Spencer C., Tan Xiang-Yang, Luxenberg Deborah P., Karim Riyez, Dunussi-Joannopoulos Kyriaki, Collins Mary, Fouser Lynette A., Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides, 10.1084/jem.20061308
  33. Wolk Kerstin, Sabat Robert, Interleukin-22: A novel T- and NK-cell derived cytokine that regulates the biology of tissue cells, 10.1016/j.cytogfr.2006.09.001
  34. Ikeuchi Hidekazu, Kuroiwa Takashi, Hiramatsu Noriyuki, Kaneko Yoriaki, Hiromura Keiju, Ueki Kazue, Nojima Yoshihisa, Expression of interleukin-22 in rheumatoid arthritis: Potential role as a proinflammatory cytokine, 10.1002/art.20965
  35. Zheng Yan, Danilenko Dimitry M., Valdez Patricia, Kasman Ian, Eastham-Anderson Jeffrey, Wu Jianfeng, Ouyang Wenjun, Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis, 10.1038/nature05505
  36. Wolk Kerstin, Haugen Harald S., Xu Wenfeng, Witte Ellen, Waggie Kim, Anderson Monica, vom Baur Elmar, Witte Katrin, Warszawska Katarzyna, Philipp Sandra, Johnson-Leger Caroline, Volk Hans-Dieter, Sterry Wolfram, Sabat Robert, IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-γ are not, 10.1007/s00109-009-0457-0
  37. Kotenko Sergei V., Izotova Lara S., Mirochnitchenko Olga V., Esterova Elena, Dickensheets Harold, Donnelly Raymond P., Pestka Sidney, Identification of the Functional Interleukin-22 (IL-22) Receptor Complex : THE IL-10R2 CHAIN (IL-10Rβ) IS A COMMON CHAIN OF BOTH THE IL-10 AND IL-22 (IL-10-RELATED T CELL-DERIVED INDUCIBLE FACTOR, IL-TIF) RECEPTOR COMPLEXES, 10.1074/jbc.m007837200
  38. Ouyang Wenjun, Rutz Sascha, Crellin Natasha K., Valdez Patricia A., Hymowitz Sarah G., Regulation and Functions of the IL-10 Family of Cytokines in Inflammation and Disease, 10.1146/annurev-immunol-031210-101312
  39. Boniface K., Bernard F.-X., Garcia M., Gurney A. L., Lecron J.-C., Morel F., IL-22 Inhibits Epidermal Differentiation and Induces Proinflammatory Gene Expression and Migration of Human Keratinocytes, 10.4049/jimmunol.174.6.3695
  40. Li Wei, Danilenko Dimitry M., Bunting Stuart, Ganesan Rajkumar, Sa Susan, Ferrando Ronald, Wu Thomas D., Kolumam Ganesh A., Ouyang Wenjun, Kirchhofer Daniel, The Serine Protease Marapsin Is Expressed in Stratified Squamous Epithelia and Is Up-regulated in the Hyperproliferative Epidermis of Psoriasis and Regenerating Wounds, 10.1074/jbc.m806267200
  41. Lejeune Diane, Dumoutier Laure, Constantinescu Stefan, Kruijer Wiebe, Schuringa Jan Jacob, Renauld Jean-Christophe, Interleukin-22 (IL-22) Activates the JAK/STAT, ERK, JNK, and p38 MAP Kinase Pathways in a Rat Hepatoma Cell Line : PATHWAYS THAT ARE SHARED WITH AND DISTINCT FROM IL-10, 10.1074/jbc.m204204200
  42. Nakagome Kazuyuki, Imamura Mitsuru, Kawahata Kimito, Harada Hiroaki, Okunishi Katsuhide, Matsumoto Taku, Sasaki Oh, Tanaka Ryoichi, Kano Mitsunobu R., Chang He, Hanawa Haruo, Miyazaki Jun-ichi, Yamamoto Kazuhiko, Dohi Makoto, High Expression of IL-22 Suppresses Antigen-Induced Immune Responses and Eosinophilic Airway Inflammation via an IL-10–Associated Mechanism, 10.4049/jimmunol.1001560
  43. Van Belle A. B., de Heusch M., Lemaire M. M., Hendrickx E., Warnier G., Dunussi-Joannopoulos K., Fouser L. A., Renauld J.-C., Dumoutier L., IL-22 Is Required for Imiquimod-Induced Psoriasiform Skin Inflammation in Mice, 10.4049/jimmunol.1102224
  44. Mitra Anupam, Raychaudhuri Smriti K, Raychaudhuri Siba P, Functional role of IL-22 in psoriatic arthritis, 10.1186/ar3781
  45. Keane Joseph, Gershon Sharon, Wise Robert P., Mirabile-Levens Elizabeth, Kasznica John, Schwieterman William D., Siegel Jeffrey N., Braun M. Miles, Tuberculosis Associated with Infliximab, a Tumor Necrosis Factor α–Neutralizing Agent, 10.1056/nejmoa011110
  46. Mohan A. K., Timothy R. C., Block J. A., Manadan A. M., Siegel J. N., Braun M. M., Tuberculosis following the Use of Etanercept, a Tumor Necrosis Factor Inhibitor, 10.1086/421494
  47. Dhiman R., Periasamy S., Barnes P. F., Jaiswal A. G., Paidipally P., Barnes A. B., Tvinnereim A., Vankayalapati R., NK1.1+ Cells and IL-22 Regulate Vaccine-Induced Protective Immunity against Challenge with Mycobacterium tuberculosis, 10.4049/jimmunol.1102833
  48. Dhiman R., Indramohan M., Barnes P. F., Nayak R. C., Paidipally P., Rao L. V. M., Vankayalapati R., IL-22 Produced by Human NK Cells Inhibits Growth of Mycobacterium tuberculosis by Enhancing Phagolysosomal Fusion, 10.4049/jimmunol.0902587
  49. Wilson M. S., Feng C. G., Barber D. L., Yarovinsky F., Cheever A. W., Sher A., Grigg M., Collins M., Fouser L., Wynn T. A., Redundant and Pathogenic Roles for IL-22 in Mycobacterial, Protozoan, and Helminth Infections, 10.4049/jimmunol.0903416
  50. Tsai Ming C., Chakravarty Soumya, Zhu Guofeng, Xu Jiayong, Tanaka Kathryn, Koch Cameron, Tufariello JoAnn, Flynn JoAnne, Chan John, Characterization of the tuberculous granuloma in murine and human lungs: cellular composition and relative tissue oxygen tension, 10.1111/j.1462-5822.2005.00612.x
  51. Maglione Paul J., Chan John, How B cells shape the immune response againstMycobacterium tuberculosis : HIGHLIGHTS, 10.1002/eji.200839148
  52. Maglione P. J., Xu J., Chan J., B Cells Moderate Inflammatory Progression and Enhance Bacterial Containment upon Pulmonary Challenge with Mycobacterium tuberculosis, 10.4049/jimmunol.178.11.7222
  53. Khader Shabaana A., Guglani Lokesh, Rangel-Moreno Javier, Gopal Radha, Fallert Junecko Beth A., Fountain Jeffrey J., Martino Cynthia, Pearl John E., Tighe Michael, Lin Yin-yao, Slight Samantha, Kolls Jay K., Reinhart Todd A., Randall Troy D., Cooper Andrea M., IL-23 Is Required for Long-Term Control of Mycobacterium tuberculosis and B Cell Follicle Formation in the Infected Lung , 10.4049/jimmunol.1101377
  54. Wolk Kerstin, Kunz Stefanie, Witte Ellen, Friedrich Markus, Asadullah Khusru, Sabat Robert, IL-22 Increases the Innate Immunity of Tissues, 10.1016/j.immuni.2004.07.007
  55. Zheng Yan, Valdez Patricia A, Danilenko Dimitry M, Hu Yan, Sa Susan M, Gong Qian, Abbas Alexander R, Modrusan Zora, Ghilardi Nico, de Sauvage Frederic J, Ouyang Wenjun, Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens, 10.1038/nm1720
  56. Aujla Shean J, Chan Yvonne R, Zheng Mingquan, Fei Mingjian, Askew David J, Pociask Derek A, Reinhart Todd A, McAllister Florencia, Edeal Jennifer, Gaus Kristi, Husain Shahid, Kreindler James L, Dubin Patricia J, Pilewski Joseph M, Myerburg Mike M, Mason Carol A, Iwakura Yoichiro, Kolls Jay K, IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia, 10.1038/nm1710
  57. Stange J., Hepworth M. R., Rausch S., Zajic L., Kuhl A. A., Uyttenhove C., Renauld J.-C., Hartmann S., Lucius R., IL-22 Mediates Host Defense against an Intestinal Intracellular Parasite in the Absence of IFN-  at the Cost of Th17-Driven Immunopathology, 10.4049/jimmunol.1102062
  58. Henao-Tamayo M. I., Ordway D. J., Irwin S. M., Shang S., Shanley C., Orme I. M., Phenotypic Definition of Effector and Memory T-Lymphocyte Subsets in Mice Chronically Infected with Mycobacterium tuberculosis, 10.1128/cvi.00368-09
  59. Sallusto Federica, Geginat Jens, Lanzavecchia Antonio, Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance, 10.1146/annurev.immunol.22.012703.104702
  60. Zeng G., Chen C. Y., Huang D., Yao S., Wang R. C., Chen Z. W., Membrane-Bound IL-22 after De Novo Production in Tuberculosis and Anti-Mycobacterium tuberculosis Effector Function of IL-22+ CD4+ T Cells, 10.4049/jimmunol.1004129
  61. MacMicking J. D., North R. J., LaCourse R., Mudgett J. S., Shah S. K., Nathan C. F., Identification of nitric oxide synthase as a protective locus against tuberculosis, 10.1073/pnas.94.10.5243
  62. MacMicking J. D., Immune Control of Tuberculosis by IFN- -Inducible LRG-47, 10.1126/science.1088063
  63. S Eyerich, J Clin Invest, 119, 3573 (2009)
  64. Zenewicz L. A., Flavell R. A., Recent advances in IL-22 biology, 10.1093/intimm/dxr001
  65. Lee Yun Kyung, Mukasa Ryuta, Hatton Robin D, Weaver Casey T, Developmental plasticity of Th17 and Treg cells, 10.1016/j.coi.2009.05.021
  66. Lee Yun Kyung, Turner Henrietta, Maynard Craig L., Oliver James R., Chen Dongquan, Elson Charles O., Weaver Casey T., Late Developmental Plasticity in the T Helper 17 Lineage, 10.1016/j.immuni.2008.11.005
  67. Hirota Keiji, Duarte João H, Veldhoen Marc, Hornsby Eve, Li Ying, Cua Daniel J, Ahlfors Helena, Wilhelm Christoph, Tolaini Mauro, Menzel Ursula, Garefalaki Anna, Potocnik Alexandre J, Stockinger Brigitta, Fate mapping of IL-17-producing T cells in inflammatory responses, 10.1038/ni.1993
  68. Stumhofer J.S., Silver J., Hunter C.A., Negative regulation of Th17 responses, 10.1016/j.smim.2007.11.006
  69. Flynn JoAnne L., Chan John, IMMUNOLOGY OF TUBERCULOSIS, 10.1146/annurev.immunol.19.1.93
  70. Mohan Karkada, Cordeiro Erin, Vaci Maria, McMaster Christopher, Issekutz Thomas B., CXCR3 is required for migration to dermal inflammation by normal andin vivo activated T cells: differential requirements by CD4 and CD8 memory subsets, 10.1002/eji.200425885
  71. Benson Heather L., Mobashery Shahriar, Chang Mayland, Kheradmand Farrah, Hong Jeong Soo, Smith Gerald N., Shilling Rebecca A., Wilkes David S., Endogenous Matrix Metalloproteinases 2 and 9 Regulate Activation of CD4+and CD8+T cells, 10.1165/rcmb.2010-0125oc
  72. Kumar P, Thakar M S, Ouyang W, Malarkannan S, IL-22 from conventional NK cells is epithelial regenerative and inflammation protective during influenza infection, 10.1038/mi.2012.49