User menu

Endothelial cell metabolism and tumour angiogenesis: glucose and glutamine as essential fuels and lactate as the driving force.

Bibliographic reference Feron, Olivier ; Polet, Florence. Endothelial cell metabolism and tumour angiogenesis: glucose and glutamine as essential fuels and lactate as the driving force.. In: Journal of Internal Medicine, Vol. 273, no. 2, p. 156-165 (Février 2013)
Permanent URL
  1. Pries A. R., Reglin B., Secomb T. W., Structural response of microcirculatory networks to changes in demand: information transfer by shear stress, 10.1152/ajpheart.00757.2002
  2. Balligand J.-L., Feron O., Dessy C., eNOS Activation by Physical Forces: From Short-Term Regulation of Contraction to Chronic Remodeling of Cardiovascular Tissues, 10.1152/physrev.00042.2007
  3. Victor V. M., Nunez C., D'Ocon P., Taylor C. T., Esplugues J. V., Moncada S., Regulation of Oxygen Distribution in Tissues by Endothelial Nitric Oxide, 10.1161/circresaha.109.197228
  4. Sonveaux Pierre, Jordan Bénédicte F., Gallez Bernard, Feron Olivier, Nitric oxide delivery to cancer: Why and how?, 10.1016/j.ejca.2008.12.018
  5. Vander Heiden Matthew G., Targeting cancer metabolism: a therapeutic window opens, 10.1038/nrd3504
  6. Fraisl Peter, Mazzone Massimiliano, Schmidt Thomas, Carmeliet Peter, Regulation of Angiogenesis by Oxygen and Metabolism, 10.1016/j.devcel.2009.01.003
  7. Warburg, Science, 124, 269 (1956)
  8. Matsumoto S., Yasui H., Mitchell J. B., Krishna M. C., Imaging Cycling Tumor Hypoxia, 10.1158/0008-5472.can-10-2821
  9. Baudelet Christine, Ansiaux Réginald, Jordan Bénédicte F, Havaux Xavier, Macq Benoit, Gallez Bernard, Physiological noise in murine solid tumours using T2*-weighted gradient-echo imaging: a marker of tumour acute hypoxia?, 10.1088/0031-9155/49/15/006
  10. Bennewith Kevin L., Durand Ralph E., Quantifying Transient Hypoxia in Human Tumor Xenografts by Flow Cytometry, 10.1158/0008-5472.can-04-0289
  11. Bristow Robert G., Hill Richard P., Hypoxia and metabolism: Hypoxia, DNA repair and genetic instability, 10.1038/nrc2344
  12. Kimura, Cancer Res, 56, 5522 (1996)
  13. Lanzen Jennifer, Braun Rod D., Klitzman Bruce, Brizel David, Secomb Timothy W., Dewhirst Mark W., Direct Demonstration of Instabilities in Oxygen Concentrations within the Extravascular Compartment of an Experimental Tumor, 10.1158/0008-5472.can-03-2958
  14. Brurberg Kjetil G., Benjaminsen Ilana C., Dørum Liv M.R., Rofstad Einar K., Fluctuations in tumor blood perfusion assessed by dynamic contrast-enhanced MRI, 10.1002/mrm.21367
  15. Cairns Rob A., Hill Richard P., Acute Hypoxia Enhances Spontaneous Lymph Node Metastasis in an Orthotopic Murine Model of Human Cervical Carcinoma, 10.1158/0008-5472.can-03-3196
  16. Rofstad E. K., Galappathi K., Mathiesen B., Ruud E.-B. M., Fluctuating and Diffusion-Limited Hypoxia in Hypoxia-Induced Metastasis, 10.1158/1078-0432.ccr-06-1967
  17. Dewhirst Mark W., Cao Yiting, Moeller Benjamin, Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response, 10.1038/nrc2397
  18. Daneau G., Boidot R., Martinive P., Feron O., Identification of Cyclooxygenase-2 as a Major Actor of the Transcriptomic Adaptation of Endothelial and Tumor Cells to Cyclic Hypoxia: Effect on Angiogenesis and Metastases, 10.1158/1078-0432.ccr-09-0583
  19. Martinive P., Defresne F., Bouzin C., Saliez J., Lair F., Gregoire V., Michiels C., Dessy C., Feron O., Preconditioning of the Tumor Vasculature and Tumor Cells by Intermittent Hypoxia: Implications for Anticancer Therapies, 10.1158/0008-5472.can-06-2056
  20. Martinive P., Reversal of temporal and spatial heterogeneities in tumor perfusion identifies the tumor vascular tone as a tunable variable to improve drug delivery, 10.1158/1535-7163.mct-05-0472
  21. Hausenloy Derek J., Yellon Derek M., The therapeutic potential of ischemic conditioning: an update, 10.1038/nrcardio.2011.85
  22. Rath G., Saliez J., Behets G., Romero-Perez M., Leon-Gomez E., Bouzin C., Vriens J., Nilius B., Feron O., Dessy C., Vascular Hypoxic Preconditioning Relies on TRPV4-Dependent Calcium Influx and Proper Intercellular Gap Junctions Communication, 10.1161/atvbaha.112.252783
  23. Rojas J. D., Vacuolar-type H+-ATPases at the plasma membrane regulate pH and cell migration in microvascular endothelial cells, 10.1152/ajpheart.00166.2006
  24. Feron Olivier, Pyruvate into lactate and back: From the Warburg effect to symbiotic energy fuel exchange in cancer cells, 10.1016/j.radonc.2009.06.025
  25. Porporato Paolo E., Dhup Suveera, Dadhich Rajesh K., Copetti Tamara, Sonveaux Pierre, Anticancer Targets in the Glycolytic Metabolism of Tumors: A Comprehensive Review, 10.3389/fphar.2011.00049
  26. Pfeiffer T., Schuster S., Bonhoeffer S., Cooperation and Competition in the Evolution of ATP-Producing Pathways, 10.1126/science.1058079
  27. Boidot R., Vegran F., Meulle A., Le Breton A., Dessy C., Sonveaux P., Lizard-Nacol S., Feron O., Regulation of Monocarboxylate Transporter MCT1 Expression by p53 Mediates Inward and Outward Lactate Fluxes in Tumors, 10.1158/0008-5472.can-11-2474
  28. Vegran F., Boidot R., Michiels C., Sonveaux P., Feron O., Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF- B/IL-8 Pathway that Drives Tumor Angiogenesis, 10.1158/0008-5472.can-10-2828
  29. Sonveaux Pierre, Copetti Tamara, De Saedeleer Christophe J., Végran Frédérique, Verrax Julien, Kennedy Kelly M., Moon Eui Jung, Dhup Suveera, Danhier Pierre, Frérart Françoise, Gallez Bernard, Ribeiro Anthony, Michiels Carine, Dewhirst Mark W., Feron Olivier, Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis, 10.1371/journal.pone.0033418
  30. Aird W. C., Phenotypic Heterogeneity of the Endothelium: I. Structure, Function, and Mechanisms, 10.1161/01.res.0000255691.76142.4a
  31. Wise David R., Thompson Craig B., Glutamine addiction: a new therapeutic target in cancer, 10.1016/j.tibs.2010.05.003
  32. Leighton Brendan, Curi Rui, Hussein Anwar, Newsholme Eric A., Maximum activities of some key enzymes of glycolysis, glutaminolysis, Krebs cycle and fatty acid utilization in bovine pulmonary endothelial cells, 10.1016/0014-5793(87)81137-7
  33. Unterluggauer Hermann, Mazurek Sybille, Lener Barbara, Hütter Eveline, Eigenbrodt Erich, Zwerschke Werner, Jansen-Dürr Pidder, Premature senescence of human endothelial cells induced by inhibition of glutaminase, 10.1007/s10522-008-9134-x
  34. Bobrovnikova-Marjon Ekaterina V., Marjon Philip L., Barbash Olena, Vander Jagt David L., Abcouwer Steve F., Expression of Angiogenic Factors Vascular Endothelial Growth Factor and Interleukin-8/CXCL8 Is Highly Responsive to Ambient Glutamine Availability : Role of Nuclear Factor-κB and Activating Protein-1, 10.1158/0008-5472.can-04-0682
  35. Hirschhaeuser F., Sattler U. G. A., Mueller-Klieser W., Lactate: A Metabolic Key Player in Cancer, 10.1158/0008-5472.can-11-1457
  36. Sonveaux, J Clin Invest, 118, 3930 (2008)
  37. Lu Huasheng, Dalgard Clifton L., Mohyeldin Ahmed, McFate Thomas, Tait A. Sasha, Verma Ajay, Reversible Inactivation of HIF-1 Prolyl Hydroxylases Allows Cell Metabolism to Control Basal HIF-1, 10.1074/jbc.m508718200
  38. Cummins E. P., Berra E., Comerford K. M., Ginouves A., Fitzgerald K. T., Seeballuck F., Godson C., Nielsen J. E., Moynagh P., Pouyssegur J., Taylor C. T., Prolyl hydroxylase-1 negatively regulates I B kinase-beta, giving insight into hypoxia-induced NF B activity, 10.1073/pnas.0602235103
  39. Chan Denise A., Kawahara Tiara L.A., Sutphin Patrick D., Chang Howard Y., Chi Jen-Tsan, Giaccia Amato J., Tumor Vasculature Is Regulated by PHD2-Mediated Angiogenesis and Bone Marrow-Derived Cell Recruitment, 10.1016/j.ccr.2009.04.010
  40. Ameln A. K.-v., Muschter A., Mamlouk S., Kalucka J., Prade I., Franke K., Rezaei M., Poitz D. M., Breier G., Wielockx B., Inhibition of HIF Prolyl Hydroxylase-2 Blocks Tumor Growth in Mice through the Antiproliferative Activity of TGF , 10.1158/0008-5472.can-10-3838
  41. Chan D A, Giaccia A J, PHD2 in tumour angiogenesis, 10.1038/sj.bjc.6605682
  42. Ladroue C., Hoogewijs D., Gad S., Carcenac R., Storti F., Barrois M., Gimenez-Roqueplo A.-P., Leporrier M., Casadevall N., Hermine O., Kiladjian J.-J., Baruchel A., Fakhoury F., Bressac-de Paillerets B., Feunteun J., Mazure N., Pouyssegur J., Wenger R. H., Richard S., Gardie B., Distinct deregulation of the hypoxia inducible factor by PHD2 mutants identified in germline DNA of patients with polycythemia, 10.3324/haematol.2011.044644
  43. Hatzimichael Eleftheria, Dasoula Aggeliki, Shah Reshma, Syed Nelofer, Papoudou-Bai Alexandra, Coley Helen M., Dranitsaris George, Bourantas Konstantinos L., Stebbing Justin, Crook Tim, The prolyl-hydroxylase EGLN3 and not EGLN1 is inactivated by methylation in plasma cell neoplasia : EGLN3 methylation in plasma cell neoplasia, 10.1111/j.1600-0609.2009.01344.x
  44. Mazzone Massimiliano, Dettori Daniela, Leite de Oliveira Rodrigo, Loges Sonja, Schmidt Thomas, Jonckx Bart, Tian Ya-Min, Lanahan Anthony A., Pollard Patrick, Ruiz de Almodovar Carmen, De Smet Frederik, Vinckier Stefan, Aragonés Julián, Debackere Koen, Luttun Aernout, Wyns Sabine, Jordan Benedicte, Pisacane Alberto, Gallez Bernard, Lampugnani Maria Grazia, Dejana Elisabetta, Simons Michael, Ratcliffe Peter, Maxwell Patrick, Carmeliet Peter, Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization, 10.1016/j.cell.2009.01.020
  45. Ebos John M. L., Kerbel Robert S., Antiangiogenic therapy: impact on invasion, disease progression, and metastasis, 10.1038/nrclinonc.2011.21
  46. Potente Michael, Gerhardt Holger, Carmeliet Peter, Basic and Therapeutic Aspects of Angiogenesis, 10.1016/j.cell.2011.08.039
  47. Feron Olivier, Challenges in Pharmacotherapy of Neoplastic Diseases – The Search for Addictions, 10.3389/fphar.2010.00120
  48. Draoui N., Feron O., Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments, 10.1242/dmm.007724