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Effects of intrathecal ketamine in the neonatal rat: evaluation of apoptosis and long-term functional outcome.

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Walker, Suellen M Westin, B David Deumens, Ronald [UCL] Grafe, Marjorie Yaksh, Tony L

Because acute pathology and long-term behavioral change occurred in the same dose range as antihyperalgesic effects, the therapeutic ratio of intrathecal ketamine is less than one in the neonatal rat. This measure facilitates comparison of the relative safety of spinally administered analgesic agents.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2010
Language Anglais
Journal information "Anesthesiology" - Vol. 113, no.1, p. 147-59 (2010)
Peer reviewed yes
Publisher Lippincott Williams & Wilkins ((United States) Philadelphia)
issn 0003-3022
e-issn 1528-1175
Publication status Publié
Affiliation UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire
MESH Subject Analgesics ; Injections, Spinal ; Ketamine ; Male ; Neuroglia ; Rats ; Rats, Sprague-Dawley ; Sodium Chloride ; Spinal Cord ; Analysis of Variance ; Animals ; Animals, Newborn ; Apoptosis ; Behavior, Animal ; Dose-Response Relationship, Drug ; Female ; Gait
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Bibliographic reference Walker, Suellen M ; Westin, B David ; Deumens, Ronald ; Grafe, Marjorie ; Yaksh, Tony L. Effects of intrathecal ketamine in the neonatal rat: evaluation of apoptosis and long-term functional outcome.. In: Anesthesiology, Vol. 113, no.1, p. 147-59 (2010)
Permanent URL http://hdl.handle.net/2078.1/125354