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Sequential combined bypassing therapy is safe and effective in the treatment of unresponsive bleeding in adults and children with haemophilia and inhibitors.

Bibliographic reference Gringeri, A ; Fischer, K ; Karafoulidou, A ; Klamroth, R ; López-Fernández, M F ; et. al. Sequential combined bypassing therapy is safe and effective in the treatment of unresponsive bleeding in adults and children with haemophilia and inhibitors.. In: Haemophilia, Vol. 17, no.4, p. 630-5 (2011)
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  1. Lloyd Jones M., Wight J., Paisley S., Knight C., Control of bleeding in patients with haemophilia A with inhibitors: a systematic review, 10.1046/j.1365-2516.2003.00782.x
  2. Gringeri A., Cost of care and quality of life for patients with hemophilia complicated by inhibitors: the COCIS Study Group, 10.1182/blood-2003-03-0941
  3. Gringeri A., Mannucci P. M., , Italian guidelines for the diagnosis and treatment of patients with haemophilia and inhibitors, 10.1111/j.1365-2516.2005.01161.x
  4. Hay Charles R. M., Brown S., Collins P. W., Keeling D. M., Liesner R., The diagnosis and management of factor VIII and IX inhibitors: a guideline from the United Kingdom Haemophilia Centre Doctors Organisation, 10.1111/j.1365-2141.2006.06087.x
  5. Astermark J., Donfield S. M., DiMichele D. M., Gringeri A., Gilbert S. A., Waters J., Berntorp E., , A randomized comparison of bypassing agents in hemophilia complicated by an inhibitor: the FEIBA NovoSeven Comparative (FENOC) Study, 10.1182/blood-2006-04-017988
  6. FEIBA, VH Anti-Inhibitor Coagulant Complex Package Insert (2005)
  7. Hilgartner M, Aledort L, Andes A, Gill J, Efficacy and safety of vapor-heated anti-inhibitor coagulant complex in hemophilia patients. FEIBA Study Group, 10.1046/j.1537-2995.1990.30790385521.x
  8. Novo Nordisk A/S, NovoSeven Package Insert (2005)
  9. Macik B. G., Lindley C. M., Lusher J., Sawyer W. T., Bloom A. L., Harrison J. F., Baird-Cox K., Birch K., Glazer S., Roberts H. R., Safety and initial clinical efficacy of three dose levels of recombinant activated factor VII (rFVIIa) : results of a Phase I study, 10.1097/00001721-199308000-00001
  10. TEITEL J., BERNTORP E., COLLINS P., D'OIRON R., EWENSTEIN B., GOMPERTS E., GOUDEMAND J., GRINGERI A., KEY N., LEISSINGER C., MONAHAN P., YOUNG G., A systematic approach to controlling problem bleeds in patients with severe congenital haemophilia A and high-titre inhibitors, 10.1111/j.1365-2516.2007.01449.x
  11. BERNTORP E., Differential response to bypassing agents complicates treatment in patients with haemophilia and inhibitors, 10.1111/j.1365-2516.2008.01931.x
  12. Key, Haemophilia, 88, 60 (2002)
  13. Tomokiyo K., Nakatomi Y., Araki T., Teshima K., Nakano H., Nakagaki T., Miyamoto S., Funatsu A., Iwanaga S., A novel therapeutic approach combining human plasma-derived Factors VIIa and X for haemophiliacs with inhibitors: evidence of a higher thrombin generation rate in vitro and more sustained haemostatic activity in vivo than obtained with Factor VIIa alone, 10.1111/j.0042-9007.2003.00365.x
  14. Allen Geoffrey A., Hoffman Maureane, Roberts Harold R., Monroe Dougald M., Manipulation of prothrombin concentration improves response to high-dose factor VIIa in a cell-based model of haemophilia, 10.1111/j.1365-2141.2006.06178.x
  15. Schneiderman J., Nugent D. J., Young G., Sequential therapy with activated prothrombin complex concentrate and recombinant factor VIIa in patients with severe haemophilia and inhibitors, 10.1111/j.1365-2516.2004.00912.x
  16. SCHNEIDERMAN J., RUBIN E., NUGENT D. J., YOUNG G., Sequential therapy with activated prothrombin complex concentrates and recombinant FVIIa in patients with severe haemophilia and inhibitors: update of our previous experience, 10.1111/j.1365-2516.2007.01451.x
  18. TOH C. H., HOOTS W. K., , The scoring system of the Scientific and Standardisation Committee on Disseminated Intravascular Coagulation of the International Society on Thrombosis and Haemostasis: a 5-year overview, 10.1111/j.1538-7836.2007.02313.x
  19. KRAUT E. H., ALEDORT L. M., ARKIN S., STINE K. C., WONG W.-Y., Surgical interventions in a cohort of patients with haemophilia A and inhibitors: an experiential retrospective chart review, 10.1111/j.1365-2516.2007.01523.x
  20. MARTINOWITZ U., LIVNAT T., ZIVELIN A., KENET G., Concomitant infusion of low doses of rFVIIa and FEIBA in haemophilia patients with inhibitors, 10.1111/j.1365-2516.2009.02028.x