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Downregulation of pIgR expression in patients with chronic rhinosinusitis

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Hupin, Cloé [UCL] Lecocq, Marylène [UCL] Rombaux, Philippe [UCL] Pilette, Charles [UCL]

IgA represents a frontline defense factor in the airways, which is transported across the surface epithelium after binding to the polymeric immunoglobulin receptor (pIgR). We observed that pIgR immunostaining is reduced in patients with severe COPD (Pilette, 2001) and correlated to reduced lung function and neutrophilic infiltration. Whether mechanisms of IgA secretion are affected in chronic rhinosinusitis (CRS) remains poorly known.

Document type Communication à un colloque (Conference Paper) – Présentation orale avec comité de sélection
Publication date 2010
Language Anglais
Conference "EAACI-ERAM-SERIN", Brussels, Belgium (du 04/11/2010 au 06/11/2010)
Affiliations UCL - SSS/IONS/NEUR - Clinical Neuroscience
UCL - (SLuc) Service d'oto-rhino-laryngologie
Links
Bibliographic reference Hupin, Cloé ; Lecocq, Marylène ; Rombaux, Philippe ; Pilette, Charles. Downregulation of pIgR expression in patients with chronic rhinosinusitis.EAACI-ERAM-SERIN (Brussels, Belgium, du 04/11/2010 au 06/11/2010).
Permanent URL http://hdl.handle.net/2078/125037