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Interferon β-1b-neutralizing antibodies 5 years after clinically isolated syndrome.

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Hartung, H-P Freedman, M S Polman, C H Edan, G Kappos, L Sindic, Christian [UCL]

Although NAb positivity was associated with increased brain MRI activity, no discernible effects on clinical outcomes were found. This finding may reflect the greater power of MRI compared with clinical outcomes to detect the treatment effects of IFNβ-1b and may also result from temporal changes in NAb titers and biology.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2011
Language Anglais
Journal information "Neurology" - Vol. 77, no.9, p. 835-43 (2011)
Peer reviewed yes
issn 0028-3878
Publication status Publié
Affiliations UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire
UCL - (SLuc) Service de neurologie
MESH Subject Antibodies, Neutralizing ; Prospective Studies ; Cross-Sectional Studies ; Demyelinating Diseases ; Follow-Up Studies ; Humans ; Injections, Subcutaneous ; Interferon-beta ; Longitudinal Studies ; Multiple Sclerosis
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Bibliographic reference Hartung, H-P ; Freedman, M S ; Polman, C H ; Edan, G ; Kappos, L ; et. al. Interferon β-1b-neutralizing antibodies 5 years after clinically isolated syndrome.. In: Neurology, Vol. 77, no.9, p. 835-43 (2011)
Permanent URL http://hdl.handle.net/2078.1/124900