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Cerebrospinal fluid biomarkers in multiple sclerosis.

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Tumani, Hayrettin Hartung, Hans-Peter Hemmer, Bernhard Teunissen, Charlotte Deisenhammer, Florian Van Pesch, Vincent [UCL]

In patients with multiple sclerosis (MS) intensive efforts are directed at identifying biomarkers in bodily fluids related to underlying disease mechanisms, disease activity and progression, and therapeutic response. Besides MR imaging parameters cerebrospinal fluid (CSF) biomarkers provide important and specific information since changes in the CSF composition may reflect disease mechanisms inherent to MS. The different cellular and protein-analytical methods of the CSF and the recommended standard of the diagnostic CSF profile in MS are described. A brief update on possible CSF biomarkers that might reflect key pathological processes of MS such as inflammation, demyelination, neuroaxonal loss, gliosis and regeneration is provided.

Document type Article de périodique (Journal article)
Access type Accès restreint
Publication date 2009
Language Anglais
Journal information "Neurobiology of Disease" - Vol. 35, no.2, p. 117-27 (2009)
Peer reviewed yes
Publisher Academic Press ((United States) San Diego)
issn 0969-9961
e-issn 1095-953X
Publication status Publié
Affiliations UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire
UCL - (SLuc) Service de neurologie
UCL - MD/NOPS - Département de neurologie et de psychiatrie
MESH Subject Axons ; Oxidative Stress ; Prognosis ; Biological Markers ; Blood-Brain Barrier ; Cerebrospinal Fluid ; Diagnosis, Differential ; Humans ; Multiple Sclerosis ; Myelin Sheath ; Neuroglia
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Bibliographic reference Tumani, Hayrettin ; Hartung, Hans-Peter ; Hemmer, Bernhard ; Teunissen, Charlotte ; Deisenhammer, Florian ; et. al. Cerebrospinal fluid biomarkers in multiple sclerosis.. In: Neurobiology of Disease, Vol. 35, no.2, p. 117-27 (2009)
Permanent URL http://hdl.handle.net/2078.1/124846