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Fertility preservation: current prospects and future challenges.

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Wyns, Christine [UCL]

(eng) Due to remarkable advances in cancer therapies, we have seen great improvements in survival rates of pediatric and reproductive-age male patients. Unfortunately, fertility in adult life might be severely impaired by these treatments. Gonadotoxic therapy is also used to cure a variety of non-malignant disorders. Providing young people undergoing gonadotoxic treatment with adequate fertility preservation options is a challenging area of reproductive medicine and merits broader diffusion in clinical practice. This paper, therefore, aims to review current concepts and perspectives to restore fertility from germ cells or gonadal tissue cryostored prior to gonadotoxic therapies in pre- and post-pubertal patients. For patients rendered sterile after treatment, who did not benefit from fertility preservation measures before therapy, the reproductive potential of alternative sources of stem cells is also examined, although this is at the research stage.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2013
Language Anglais
Journal information "Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology" - Vol. 29, no. 5, p. 403-407 (2013)
Peer reviewed yes
Publisher Informa Healthcare ((United Kingdom) London)
issn 0951-3590
e-issn 1473-0766
Publication status Publié
Affiliations UCL - SSS/IREC/GYNE - Pôle de Gynécologie
UCL - (SLuc) Service de gynécologie et d'andrologie
Keywords Cancer ; Cryopreservation ; Fertility preservation ; Stem cells ; Transplantation
Links
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Bibliographic reference Wyns, Christine. Fertility preservation: current prospects and future challenges.. In: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, Vol. 29, no. 5, p. 403-407 (2013)
Permanent URL http://hdl.handle.net/2078.1/124592