User menu

Tryptophan at the transmembrane-cytosolic junction modulates thrombopoietin receptor dimerization and activation.

Bibliographic reference Defour, Jean-Philippe ; Itaya, Miki ; Gryshkova, Vitalina ; Brett, Ian C ; Pecquet, Christian ; et. al. Tryptophan at the transmembrane-cytosolic junction modulates thrombopoietin receptor dimerization and activation.. In: Proceedings of the National academy of sciences of the United States of America, Vol. 110, no.7, p. 2540-5 (2013)
Permanent URL http://hdl.handle.net/2078.1/124118
  1. Drachman Jonathan G., Griffin James D., Kaushansky Kenneth, The c-Mpl Ligand (Thrombopoietin) Stimulates Tyrosine Phosphorylation of Jak2, Shc, and c-Mpl, 10.1074/jbc.270.10.4979
  2. Royer Yohan, Staerk Judith, Costuleanu Marcel, Courtoy Pierre J., Constantinescu Stefan N., Janus Kinases Affect Thrombopoietin Receptor Cell Surface Localization and Stability, 10.1074/jbc.m501376200
  3. Hubbard Stevan R., Juxtamembrane autoinhibition in receptor tyrosine kinases, 10.1038/nrm1399
  4. Solar, Blood, 92, 4 (1998)
  5. Yoshihara Hiroki, Arai Fumio, Hosokawa Kentaro, Hagiwara Tetsuya, Takubo Keiyo, Nakamura Yuka, Gomei Yumiko, Iwasaki Hiroko, Matsuoka Sahoko, Miyamoto Kana, Miyazaki Hiroshi, Takahashi Takao, Suda Toshio, Thrombopoietin/MPL Signaling Regulates Hematopoietic Stem Cell Quiescence and Interaction with the Osteoblastic Niche, 10.1016/j.stem.2007.10.020
  6. Qian Hong, Buza-Vidas Natalija, Hyland Craig D., Jensen Christina T., Antonchuk Jennifer, Månsson Robert, Thoren Lina A., Ekblom Marja, Alexander Warren S., Jacobsen Sten Eirik W., Critical Role of Thrombopoietin in Maintaining Adult Quiescent Hematopoietic Stem Cells, 10.1016/j.stem.2007.10.008
  7. de Sauvage F. J., Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin, 10.1084/jem.183.2.651
  8. Kaushansky, MD K., THROMBOPOIETIN: UNDERSTANDING AND MANIPULATING PLATELET PRODUCTION, 10.1146/annurev.med.48.1.1
  9. Ding J., Familial essential thrombocythemia associated with a dominant-positive activating mutation of the c-MPL gene, which encodes for the receptor for thrombopoietin, 10.1182/blood-2003-10-3471
  10. Onishi, Blood, 88, 1399 (1996)
  11. Ding J., Komatsu H., Iida S., Yano H., Kusumoto S., Inagaki A., Mori F., Ri M., Ito A., Wakita A., Ishida T., Nitta M., Ueda R., The Asn505 mutation of the c-MPL gene, which causes familial essential thrombocythemia, induces autonomous homodimerization of the c-Mpl protein due to strong amino acid polarity, 10.1182/blood-2008-04-149047
  12. Staerk J., An amphipathic motif at the transmembrane-cytoplasmic junction prevents autonomous activation of the thrombopoietin receptor, 10.1182/blood-2005-06-2600
  13. 3, 1140 (2006)
  14. Pardanani A. D., Levine R. L., Lasho T., Pikman Y., Mesa R. A., Wadleigh M., Steensma D. P., Elliott M. A., Wolanskyj A. P., Hogan W. J., McClure R. F., Litzow M. R., Gilliland D. G., Tefferi A., MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients, 10.1182/blood-2006-04-018879
  15. Pecquet C., Staerk J., Chaligne R., Goss V., Lee K. A., Zhang X., Rush J., Van Hees J., Poirel H. A., Scheiff J.-M., Vainchenker W., Giraudier S., Polakiewicz R. D., Constantinescu S. N., Induction of myeloproliferative disorder and myelofibrosis by thrombopoietin receptor W515 mutants is mediated by cytosolic tyrosine 112 of the receptor, 10.1182/blood-2008-10-183558
  16. Boyd Elaine M., Bench Anthony J., Goday-Fernández Andrea, Anand Shubha, Vaghela Krishna J., Beer Phillip, Scott Mike A., Bareford David, Green Anthony R., Huntly Brian, Erber Wendy N., Clinical utility of routineMPLexon 10 analysis in the diagnosis of essential thrombocythaemia and primary myelofibrosis, 10.1111/j.1365-2141.2010.08083.x
  17. Beer P. A., Campbell P. J., Scott L. M., Bench A. J., Erber W. N., Bareford D., Wilkins B. S., Reilly J. T., Hasselbalch H. C., Bowman R., Wheatley K., Buck G., Harrison C. N., Green A. R., MPL mutations in myeloproliferative disorders: analysis of the PT-1 cohort, 10.1182/blood-2008-01-131664
  18. Matthews E. E., Thevenin D., Rogers J. M., Gotow L., Lira P. D., Reiter L. A., Brissette W. H., Engelman D. M., Thrombopoietin receptor activation: transmembrane helix dimerization, rotation, and allosteric modulation, 10.1096/fj.10-178673
  19. Staerk Judith, Defour Jean-Philippe, Pecquet Christian, Leroy Emilie, Antoine-Poirel Hélène, Brett Ian, Itaya Miki, Smith Steven O, Vainchenker William, Constantinescu Stefan N, Orientation-specific signalling by thrombopoietin receptor dimers : Orientation-specific TpoR signalling, 10.1038/emboj.2011.315
  20. Seubert Nadine, Royer Yohan, Staerk Judith, Kubatzky Katharina F, Moucadel Virginie, Krishnakumar Shyam, Smith Steven O, Constantinescu Stefan N, Active and Inactive Orientations of the Transmembrane and Cytosolic Domains of the Erythropoietin Receptor Dimer, 10.1016/s1097-2765(03)00389-7
  21. Abe M, Suzuki K, Inagaki O, Sassa S, Shikama H, A novel MPL point mutation resulting in thrombopoietin-independent activation, 10.1038/sj.leu.2402554
  22. Wimley William C., White Stephen H., Experimentally determined hydrophobicity scale for proteins at membrane interfaces, 10.1038/nsb1096-842
  23. Koffie R. M., Meyer-Luehmann M., Hashimoto T., Adams K. W., Mielke M. L., Garcia-Alloza M., Micheva K. D., Smith S. J., Kim M. L., Lee V. M., Hyman B. T., Spires-Jones T. L., Oligomeric amyloid   associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques, 10.1073/pnas.0811698106
  24. Kohlhuber F, Rogers N C, Watling D, Feng J, Guschin D, Briscoe J, Witthuhn B A, Kotenko S V, Pestka S, Stark G R, Ihle J N, Kerr I M, A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses., 10.1128/mcb.17.2.695
  25. Remy Ingrid, Michnick Stephen W, A highly sensitive protein-protein interaction assay based on Gaussia luciferase, 10.1038/nmeth979
  26. Gurezka Rolf, Laage Rico, Brosig Bettina, Langosch Dieter, A Heptad Motif of Leucine Residues Found in Membrane Proteins Can Drive Self-assembly of Artificial Transmembrane Segments, 10.1074/jbc.274.14.9265
  27. Ebie Alexandra Z., Fleming Karen G., Dimerization of the Erythropoietin Receptor Transmembrane Domain in Micelles, 10.1016/j.jmb.2006.11.035
  28. Ruan Weiming, Becker Verena, Klingmüller Ursula, Langosch Dieter, The Interface between Self-assembling Erythropoietin Receptor Transmembrane Segments Corresponds to a Membrane-spanning Leucine Zipper, 10.1074/jbc.m309311200
  29. Kubatzky Katharina F., Ruan Weiming, Gurezka Rolf, Cohen Jacob, Ketteler Robin, Watowich Stephanie S., Neumann Drorit, Langosch Dieter, Klingmüller Ursula, Self assembly of the transmembrane domain promotes signal transduction through the erythropoietin receptor, 10.1016/s0960-9822(01)00018-5
  30. Liu Wei, Crocker Evan, Constantinescu Stefan N., Smith Steven O., Helix Packing and Orientation in the Transmembrane Dimer of gp55-P of the Spleen Focus Forming Virus, 10.1529/biophysj.104.057844
  31. Besancenot Rodolphe, Chaligné Ronan, Tonetti Carole, Pasquier Florence, Marty Caroline, Lécluse Yann, Vainchenker William, Constantinescu Stefan N., Giraudier Stéphane, A Senescence-Like Cell-Cycle Arrest Occurs During Megakaryocytic Maturation: Implications for Physiological and Pathological Megakaryocytic Proliferation, 10.1371/journal.pbio.1000476
  32. Constantinescu S. N., Keren T., Socolovsky M., Nam H.-s., Henis Y. I., Lodish H. F., Ligand-independent oligomerization of cell-surface erythropoietin receptor is mediated by the transmembrane domain, 10.1073/pnas.081069198
  33. Brown Richard J, Adams Julian J, Pelekanos Rebecca A, Wan Yu, McKinstry William J, Palethorpe Kathryn, Seeber Ruth M, Monks Thea A, Eidne Karin A, Parker Michael W, Waters Michael J, Model for growth hormone receptor activation based on subunit rotation within a receptor dimer, 10.1038/nsmb977
  34. Arkin Isaiah T., Brunger* Axel T., Statistical analysis of predicted transmembrane α-helices, 10.1016/s0167-4838(98)00225-8
  35. de Planque Maurits R. R., Killian* J. Antoinette, Protein–lipid interactions studied with designed transmembrane peptides: role of hydrophobic matching and interfacial anchoring (Review), 10.1080/09687680310001605352
  36. Ried Christian Lothar, Kube Sebastian, Kirrbach Jan, Langosch Dieter, Homotypic Interaction and Amino Acid Distribution of Unilaterally Conserved Transmembrane Helices, 10.1016/j.jmb.2012.04.008
  37. Itaya Miki, Brett Ian C., Smith Steven O., Synthesis, Purification, and Characterization of Single Helix Membrane Peptides and Proteins for NMR Spectroscopy, Methods in Molecular Biology (2012) ISBN:9781617794797 p.333-357, 10.1007/978-1-61779-480-3_18
  38. Kochendoerfer Gerd G., Salom David, Lear James D., Wilk-Orescan Rosemarie, Kent Stephen B. H., DeGrado William F., Total Chemical Synthesis of the Integral Membrane Protein Influenza A Virus M2:  Role of Its C-Terminal Domain in Tetramer Assembly†, 10.1021/bi990720m