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Tumor-infiltrating lymphocytes: apparently good for melanoma patients. But why?

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Cipponi, Arcadi [UCL] Wieers, Grégoire [UCL] van Baren, Nicolas [UCL] Coulie, Pierre G. [UCL]

Tumor-infiltrating T lymphocytes (TILs) are observed in a number of human primary or metastatic tumors. Recently, gene expression profiling experiments suggested that the presence of T cells in metastatic melanomas before vaccinating the patients with tumor antigens could be a biomarker for clinical benefit from the vaccines. In this context, we review results pertaining to TILs in human melanomas, their prognostic value, and some possible reasons why their presence could help in selecting melanoma patients for vaccination against tumor-specific antigens.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2011
Language Anglais
Journal information "Cancer Immunology Immunotherapy" - Vol. 60, no. 8, p. 1153-60 (2011)
Peer reviewed yes
Publisher Springer ((Germany) Heidelberg)
issn 0340-7004
e-issn 1432-0851
Publication status Publié
Affiliation UCL - SSS/DDUV - Institut de Duve
MESH Subject Animals ; Patient Selection ; Prognosis ; Skin Neoplasms ; Antigens, Neoplasm ; Biomarkers, Pharmacological ; Cancer Vaccines ; Gene Expression Profiling ; Humans ; Lymphocytes, Tumor-Infiltrating ; Melanoma ; Neoplasm Metastasis
Links
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Bibliographic reference Cipponi, Arcadi ; Wieers, Grégoire ; van Baren, Nicolas ; Coulie, Pierre G.. Tumor-infiltrating lymphocytes: apparently good for melanoma patients. But why?. In: Cancer Immunology Immunotherapy, Vol. 60, no. 8, p. 1153-60 (2011)
Permanent URL http://hdl.handle.net/2078.1/124091