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IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms.

Bibliographic reference Lucas, Sophie ; Ghilardi, Nico ; Li, Ji ; de Sauvage, Frédéric J. IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms.. In: Proceedings of the National academy of sciences of the United States of America, Vol. 100, no.25, p. 15047-52 (2003)
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  1. Abbas Abul K., Murphy Kenneth M., Sher Alan, Functional diversity of helper T lymphocytes, 10.1038/383787a0
  2. Mosmann Tim R., Sad Subash, The expanding universe of T-cell subsets: Th1, Th2 and more, 10.1016/0167-5699(96)80606-2
  3. O'Garra Anne, Cytokines Induce the Development of Functionally Heterogeneous T Helper Cell Subsets, 10.1016/s1074-7613(00)80533-6
  4. Murphy Kenneth M., Reiner Steven L., Decision making in the immune system: The lineage decisions of helper T cells, 10.1038/nri954
  5. Wurster Andrea L, Tanaka Takashi, Grusby Michael J, The biology of Stat4 and Stat6, 10.1038/sj.onc.1203485
  6. Szabo Susanne J, Kim Sean T, Costa Gina L, Zhang Xiankui, Fathman C.Garrison, Glimcher Laurie H, A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment, 10.1016/s0092-8674(00)80702-3
  7. Mullen A. C., Role of T-bet in Commitment of TH1 Cells Before IL-12-Dependent Selection, 10.1126/science.1059835
  8. Afkarian Maryam, Sedy John R., Yang Jianfei, Jacobson Nils G., Cereb Nezih, Yang Soo Y., Murphy Theresa L., Murphy Kenneth M., T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells, 10.1038/ni794
  9. Szabo Susanne J., Dighe Anand S., Gubler Ueli, Murphy Kenneth M., Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells, 10.1084/jem.185.5.817
  10. Zheng Wei-ping, Flavell Richard A, The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells, 10.1016/s0092-8674(00)80240-8
  11. Zhang Dong-Hong, Cohn Lauren, Ray Prabir, Bottomly Kim, Ray Anuradha, Transcription Factor GATA-3 Is Differentially Expressed in Murine Th1 and Th2 Cells and Controls Th2-specific Expression of the Interleukin-5 Gene, 10.1074/jbc.272.34.21597
  12. Ouyang Wenjun, Ranganath Sheila H, Weindel Kathryn, Bhattacharya Deepta, Murphy Theresa L, Sha William C, Murphy Kenneth M, Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism, 10.1016/s1074-7613(00)80671-8
  13. Ouyang Wenjun, Löhning Max, Gao Zhiguang, Assenmacher Mario, Ranganath Sheila, Radbruch Andreas, Murphy Kenneth M., Stat6-Independent GATA-3 Autoactivation Directs IL-4-Independent Th2 Development and Commitment, 10.1016/s1074-7613(00)80156-9
  14. Usui Takashi, Nishikomori Ryuta, Kitani Atsushi, Strober Warren, GATA-3 Suppresses Th1 Development by Downregulation of Stat4 and Not through Effects on IL-12Rβ2 Chain or T-bet, 10.1016/s1074-7613(03)00057-8
  15. Sprecher Cindy A., Grant Francis J., Baumgartner James W., Presnell Scott R., Schrader Sara K., Yamagiwa Tina, Whitmore Theodore E., O'Hara Patrick J., Foster Donald F., Cloning and Characterization of a Novel Class I Cytokine Receptor, 10.1006/bbrc.1998.8576
  16. de Sauvage Frederic J., Chen Qi, Ghilardi Nico, Wang Hua, Baker Thad, Xie Ming-Hong, Gurney Austin, Grewal Iqbal S., 10.1038/35038103
  17. Yoshida Hiroki, Hamano Shinjiro, Senaldi Giorgio, Covey Todd, Faggioni Raffaella, Mu Sharon, Xia Min, Wakeham Andrew C, Nishina Hiroshi, Potter Julia, Saris Chris J.M, Mak Tak W, WSX-1 Is Required for the Initiation of Th1 Responses and Resistance to L. major Infection, 10.1016/s1074-7613(01)00206-0
  18. Pflanz Stefan, Timans Jackie C, Cheung Jeanne, Rosales Rency, Kanzler Holger, Gilbert Jonathan, Hibbert Linda, Churakova Tatyana, Travis Marilyn, Vaisberg Elena, Blumenschein Wendy M, Mattson Jeanine D, Wagner Janet L, To Wayne, Zurawski Sandra, McClanahan Terrill K, Gorman Daniel M, Bazan J.Fernando, de Waal Malefyt Rene, Rennick Donna, Kastelein Robert A, IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4+ T Cells, 10.1016/s1074-7613(02)00324-2
  19. Rogge Lars, Barberis-Maino Luisella, Biffi Mauro, Passini Nadia, Presky David H., Gubler Ueli, Sinigaglia Francesco, Selective Expression of an Interleukin-12 Receptor Component by Human T Helper 1 Cells, 10.1084/jem.185.5.825
  20. Bromberg J. F., Horvath C. M., Wen Z., Schreiber R. D., Darnell J. E., Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma., 10.1073/pnas.93.15.7673
  21. Ihle James N, The Stat family in cytokine signaling, 10.1016/s0955-0674(00)00199-x
  22. O'Shea John J, Gadina Massimo, Schreiber Robert D, Cytokine Signaling in 2002, 10.1016/s0092-8674(02)00701-8
  23. Strengell M., Sareneva T., Foster D., Julkunen I., Matikainen S., IL-21 Up-Regulates the Expression of Genes Associated with Innate Immunity and Th1 Response, 10.4049/jimmunol.169.7.3600
  24. Takeda A., Hamano S., Yamanaka A., Hanada T., Ishibashi T., Mak T. W., Yoshimura A., Yoshida H., Cutting Edge: Role of IL-27/WSX-1 Signaling for Induction of T-Bet Through Activation of STAT1 During Initial Th1 Commitment, 10.4049/jimmunol.170.10.4886
  25. Szabo S. J., Distinct Effects of T-bet in TH1 Lineage Commitment and IFN-gamma Production in CD4 and CD8 T Cells, 10.1126/science.1065543
  26. Lighvani A. A., Frucht D. M., Jankovic D., Yamane H., Aliberti J., Hissong B. D., Nguyen B. V., Gadina M., Sher A., Paul W. E., O'Shea J. J., T-bet is rapidly induced by interferon-  in lymphoid and myeloid cells, 10.1073/pnas.261570598