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Effects of riluzole on the evolution of focal cerebral ischemia: a magnetic resonance imaging study

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Mottet, Isabelle [UCL] Demeure, Roger [UCL] Rataud, Jean Lucas, Michelle Wahl, Florence Warscotte, Vincent [UCL] Thiran, Jean-Philippe [UCL] Goudemant, Jean-François [UCL] Maldague, Baudouin [UCL] Maloteaux, Jean-Marie [UCL] Stutzmann, Jean-Marie

The aim of this study was to investigate the effects of riluzole on the lesion induced by a permanent middle cerebral artery occlusion (MCAO) in rats. Riluzole at 4 or 8 mg/kg i.v. significantly reduced the cortical ischemic brain damage. With the most effective dose of 8 mg/kg, the time evolution of the lesion was assessed by T2-weighted magnetic resonance imaging (MRI) repeated on the same animals after MCAO. MRI obtained at 24, 48, and 72 hours after MCAO showed a progressive increase of the ischemic lesion, except in the cortex of the riluzole-treated rats (8 mg/kg i.v.). Furthermore, there was no difference between lesion volumes as measured by MRI or by histology. This study indicates that MRI may be a valuable method to quantify in vivo the neuroprotective profile of a drug.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 1997
Journal information "Magma (New York, N.Y.)" - Vol. 5, no. 3, p. 185-191 (1997)
Peer reviewed yes
issn 0968-5243
Publication status Publié
Affiliations UCL - MD/RAIM - Département de radiologie et d'imagerie médicale
UCL - (SLuc) Service de radiologie
UCL - (SLuc) Service de neurologie
MESH Subject Animals ; Brain - pathology ; Brain Ischemia - diagnosis - prevention & control ; Magnetic Resonance Imaging ; Male ; Neuroprotective Agents - administration & dosage - therapeutic use ; Rats ; Rats, Inbred F344 ; Riluzole - administration & dosage - therapeutic use ; Time Factors
Keywords Riluzole ; Brain ischemia ; Magnetic resonance imaging
Links
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Bibliographic reference Mottet, Isabelle ; Demeure, Roger ; Rataud, Jean ; Lucas, Michelle ; Wahl, Florence ; et. al. Effects of riluzole on the evolution of focal cerebral ischemia: a magnetic resonance imaging study. In: Magma (New York, N.Y.), Vol. 5, no. 3, p. 185-191 (1997)
Permanent URL http://hdl.handle.net/2078.1/12376